Patents by Inventor Ronald Gress

Ronald Gress has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11684306
    Abstract: This disclosure generally relates to stable water isotope labeling followed by detection via MRI (swiMRI), including deuterium MRI (dMRI) and 17O MRI, for visualizing rapidly dividing immune cells within target and/or lymphoid organ/s and/or tissues affected by chronic graft-versus-host disease (cGVHD). Using deuterated water labeling, followed by dMRI, a distinction in deuterium signal was detected in a target organ (e.g. liver) of the cGVHD-affected mice compared to unaffected mice, i.e. syngeneic HSCT recipient mice, where the host and donor are matched, and normal (unmanipulated) mice.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: June 27, 2023
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES et al.
    Inventors: Nataliya Buxbaum, Donald Farthing, Martin Lizak, Helmut Merkle, Natella Maglakelidze, Brittany Oliver, Ronald Gress
  • Publication number: 20190274616
    Abstract: This disclosure generally relates to stable water isotope labeling followed by detection via MRI (swiMRI), including deuterium MRI (dMRI) and 17O MRI, for visualizing rapidly dividing immune cells within target and/or lymphoid organ/s and/or tissues affected by chronic graft-versus-host disease (cGVHD). Using deuterated water labeling, followed by dMRI, a distinction in deuterium signal was detected in a target organ (e.g. liver) of the cGVHD-affected mice compared to unaffected mice, i.e. syngeneic HSCT recipient mice, where the host and donor are matched, and normal (unmanipulated) mice.
    Type: Application
    Filed: October 27, 2017
    Publication date: September 12, 2019
    Inventors: Nataliya BUXBAUM, Donald FARTHING, Martin LIZAK, Helmut MERKLE, Natella MAGLAKELIDZE, Brittany OLIVER, Ronald GRESS
  • Publication number: 20070248589
    Abstract: This disclosure provides methods useful for altering cell proliferation by modifying SPATIAL activity in cells. In some methods, thymocyte numbers in subjects with disease-associated immunodeficiencies are increased by administering an agent that inhibits SPATIAL activity. Also provided are methods useful for increasing thymocyte number in a subject by administering an agent that interferes with an interaction between SPATIAL and Uba3. In other methods, cell growth is inhibited by introducing or expressing a SPATIAL or SPATIAL-related polypeptide or nucleic acid in one or more cell(s), such as neoplastic cell(s). Further provided are methods of identifying agents that modify (for example, inhibit) SPATIAL expression or activity, or which interfere with an interaction between SPATIAL and Uba3 polypeptides, and therefore which are useful in influencing thymocyte number.
    Type: Application
    Filed: November 18, 2003
    Publication date: October 25, 2007
    Inventors: Francis Flomerfelt, Ronald Gress
  • Publication number: 20060159667
    Abstract: Methods for generating highly enriched Th1/Tcl and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also express molecules that improve immune T cell function such as CD28 and CD62L. Such rapamycin generated functional T cell subsets may have application in the prevention or treatment of GVHD after allogeneic hematopoietic stem cell transplantation, the treatment of autoimmunity, or the therapy of infection or cancer.
    Type: Application
    Filed: December 9, 2005
    Publication date: July 20, 2006
    Applicants: Gov. of the US, as represented by the Secretary, Department of Health and Human Services, The Trustees of the University of Pennsylvania
    Inventors: Daniel Fowler, Unsu Jung, Ronald Gress, Bruce Levine, Carl June