Patents by Inventor Ronald H. A. Plasterk

Ronald H. A. Plasterk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID MOLECULES AND COLLECTIONS THEREOF, THEIR APPLICATION AND MODIFICATION
    Publication number: 20150152416
    Abstract: The invention provides a method for characterising a sample comprising nucleic acid derived from a cell. The method comprises determining whether a sample comprises at least a minimal sequence of at least one new microRNA (miRNA) according to the invention or a mammalian ortholog thereof and characterizing the sample on the basis of the presence or absence of the miRNA. The invention further provides nucleic acid molecules and collections thereof and their use in therapeutic and diagnostic applications. The invention furthermore provides a method for identifying a miRNA molecule or a precursor molecule thereof.
    Type: Application
    Filed: November 24, 2014
    Publication date: June 4, 2015
    Applicant: KONINKLIJKE NEDERLANDSE AKADEMIA VAN WETENSCHAPPEN
    Inventors: Ronald H. A. PLASTERK, Eugene BEREZIKOV, Edwin Pieter CUPPEN
  • Nucleic acid molecules and collections thereof, their application and modification
    Patent number: 8895720
    Abstract: The invention provides a method for characterising a sample comprising nucleic acid derived from a cell. The method comprises determining whether a sample comprises at least a minimal sequence of at least one new microRNA (miRNA) according to the invention or a mammalian ortholog thereof and characterizing the sample on the basis of the presence or absence of the miRNA. The invention further provides nucleic acid molecules and collections thereof and their use in therapeutic and diagnostic applications. The invention furthermore provides a method for identifying a miRNA molecule or a precursor molecule thereof.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: November 25, 2014
    Assignee: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Ronald H. A. Plasterk, Eugene Berezikov, Edwin Pieter Cuppen
  • Nucleic acid molecules and collections thereof, their application and Identification
    Publication number: 20110136891
    Abstract: Provided is a method for characterising a sample comprising nucleic acid derived from a cell. The method comprises determining whether a sample comprises at least a minimal sequence of at least one new microRNA (miRNA) as disclosed herein or a mammalian ortholog thereof and characterizing the sample on the basis of the presence or absence of the miRNA. The invention further provides new nucleic acid molecules and collections thereof and their use in therapeutic and diagnostic applications. The invention furthermore provides a method for identifying a miRNA molecule or a precursor molecule thereof.
    Type: Application
    Filed: December 23, 2010
    Publication date: June 9, 2011
    Applicant: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Ronald H.A. Plasterk, Eugene Berezikov, Edwin P.J.G. Cuppen
  • Nucleic Acid molecules and Collections Thereof, Their Application and Modification
    Publication number: 20100035760
    Abstract: The invention provides a method for characterising a sample comprising nucleic acid derived from a cell. The method comprises determining whether a sample comprises at least a minimal sequence of at least one new microRNA (miRNA) according to the invention or a mammalian ortholog thereof and characterizing the sample on the basis of the presence or absence of the miRNA. The invention further provides nucleic acid molecules and collections thereof and their use in therapeutic and diagnostic applications. The invention furthermore provides a method for identifying a miRNA molecule or a precursor molecule thereof.
    Type: Application
    Filed: January 10, 2007
    Publication date: February 11, 2010
    Inventors: Ronald H.A. Plasterk, Eugene Berezikov, Edwin P.J.G. Cuppen
  • Nucleic Acid Molecules and Collections Thereof, Their Application and Identification
    Publication number: 20090215865
    Abstract: The invention provides a method for characterising a sample comprising nucleic acid derived from a cell. The method comprises determining whether a sample comprises at least a minimal sequence of at least one new microRNA (miRNA) according to the invention or a mammalian ortholog thereof and characterizing the sample on the basis of the presence or absence of the miRNA. The invention further provides new nucleic acid molecules and collections thereof and their use in therapeutic and diagnostic applications. The invention furthermore provides a method for identifying a miRNA molecule or a precursor molecule thereof.
    Type: Application
    Filed: January 10, 2006
    Publication date: August 27, 2009
    Inventors: Ronald H.A. Plasterk, Eugene Berezikov, Edwin P.J.G. Cuppen
  • Methods of screening compounds useful for prevention of infection or pathogenicity
    Patent number: 7166270
    Abstract: Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: January 23, 2007
    Assignees: The Netherlands Cancer Institute, The General Hospital Corporation
    Inventors: Frederick M. Ausubel, Laurence G. Rahme, Man-Wah Tan, Gary B. Ruvkun, Shalina Mahajan-Miklos, Annegien Broeks, Ronald H. A. Plasterk, Georg Jander, Jacqueline Heard
  • Viral integrase inhibiting peptides
    Patent number: 5578573
    Abstract: The present invention provides viral integrase inhibiting peptides having the general structure, ##STR1## where Xaa is an amino acid or an amino acid analog, the stereochemistry of the amino acids or amino acid analogs can be D-amino acids or L-amino acids and the amino and carboxy termini of the peptide can be modified. The invention also provides viral inhibiting peptides having essentially the amino acid sequence, ##STR2## The invention also provides a pharmaceutical composition comprising a viral integrase inhibiting peptide and methods of using a viral integrase inhibiting peptide in vitro or in vivo to reduce or inhibit viral integrase activity in a cell and the infectivity of a virus.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: November 26, 1996
    Assignee: Houghten Pharmaceuticals, Inc.
    Inventors: Richard A. Houghten, Patricia A. Weber, Ronald H. A. Plasterk, Ramon A. Puras Lutzke