Abstract: Provided herein are compositions comprising CXCR1/CXCR2 inhibitors as well as methods of using the CXCR1/CXCR2 inhibitors disclosed herein. In embodiments, provided are methods of treating myelofibrosis, methods of decreasing bone marrow fibrosis, methods of reducing the interaction of IL-8 to CXCR1 and/or CXCR2, and methods of reducing the activity or and/or signaling through CXCR1 and/or CXCR by administering to a subject in need thereof an effective amount of a CXCR1/CXCR2 inhibitor disclosed herein.

Abstract: A chainsaw, a lubrication system for a chainsaw, and a lubricant for a chainsaw are provided. The chainsaw includes a lubrication system and guide bar extending from a housing. The lubrication system includes a reservoir at which a lubricant is contained. The reservoir is releasably attachable to a machine drive device. The machine drive device includes a body at which a pump apparatus is positioned. The machine drive device forms an inlet opening in fluid communication with the reservoir. The machine drive device forms an outlet opening at which a conduit is fluidly coupled to receive the lubricant. The conduit forms a conduit outlet through which the lubricant is provided to the guide bar.

Abstract: The invention is directed to production of megakaryocyte (MK) compositions and their the treatment of thrombocytopenia in a subject in need thereof.

Abstract: An extraoral suction device for managing aerosol emissions during dental procedures includes: a conduit; an adapter in fluid communication with the conduit; and a mount for mounting the extraoral suction device to a dental chair. The adapter is configured to be placed in fluid communication with a vacuum source to provide suction to the extraoral suction device. The conduit can be selectively manipulated to assume and maintain a position without support from an individual or designated support structure. A dental professional can thus manipulate the conduit to maintain a position in front of the oral cavity of a patient seated in the dental chair to direct aerosols emitted from the oral cavity of the patient into the extraoral suction device instead of the surrounding environment. The extraoral suction device can thus be combined with a dental chair and vacuum source to provide an improved dental chair system for dental procedures.

Abstract: An extraoral suction device for managing aerosol emissions during dental procedures includes: a conduit; an adapter in fluid communication with the conduit; and a mount for mounting the extraoral suction device to a dental chair. The adapter is configured to be placed in fluid communication with a vacuum source to provide suction to the extraoral suction device. The conduit can be selectively manipulated to assume and maintain a position without support from an individual or designated support structure. A dental professional can thus manipulate the conduit to maintain a position in front of the oral cavity of a patient seated in the dental chair to direct aerosols emitted from the oral cavity of the patient into the extraoral suction device instead of the surrounding environment. The extraoral suction device can thus be combined with a dental chair and vacuum source to provide an improved dental chair system for dental procedures.

Abstract: This invention relates to an enriched population of isolated and expanded human cord blood stem cells and a method of producing an enriched population of isolated and expanded human cord blood stem cells. The expanded human cord blood stem cells are CD34+, CD90+, CD1 84+, CD1 17+, CD49f+, ALDH+, CD45RA? and express pluripotency genes SOX2, OCT4, NANOG, and ZIC3. In one embodiment, the stem cells in the enriched population of the present invention are positive for aldehyde dehydrogenase activity (ALDH+). In addition, in one embodiment the expanded stem cells are nearly depleted of T cells and B cells and contain a limited number of monocytes (CD14). Also disclosed is a method of treating a subject for a hematological disorder using the stem cells of the present invention and a method of determining the effects of a compound on hematopoietic stem cells.

Abstract: The invention is directed to production of megakaryocyte (MK) compositions and their the treatment of thrombocytopenia in a subject in need thereof.

Abstract: This invention relates to an enriched population of isolated and expanded human cord blood stem cells and a method of producing an enriched population of isolated and expanded human cord blood stem cells. The expanded human cord blood stem cells are CD34+, CD90+, CD1 84+, CD1 17+, CD49f+, ALDH+, CD45RA? and express pluripotency genes SOX2, OCT4, NANOG, and ZIC3. In one embodiment, the stem cells in the enriched population of the present invention are positive for aldehyde dehydrogenase activity (ALDH+). In addition, in one embodiment the expanded stem cells are nearly depleted of T cells and B cells and contain a limited number of monocytes (CD14). Also disclosed is a method of treating a subject for a hematological disorder using the stem cells of the present invention and a method of determining the effects of a compound on hematopoietic stem cells.

Abstract: An apparatus and method are provided for affixing an object to a surface. In an exemplary embodiment, the apparatus includes a magnet formed with an opening at its center. The magnet is attached to the surface by inserting a screw into the opening. A spacer and a flat washer are attached to the screw, with the spacer being positioned between the flat washer and the magnet. After the screw is affixed to the surface, a metal object can be magnetically attached to the screw and magnet to secure the object to the surface. A backer plate is also contemplated for securing non-magnetic objects to the screw and magnet. Multiple backer plates can be affixed to objects to support a greater amount of weight if required.

Abstract: An apparatus and method are provided for affixing an object to a surface. In an exemplary embodiment, the apparatus includes a magnet formed with an opening at its center. The magnet is attached to the surface by inserting a screw into the opening. A spacer and a flat washer are attached to the screw, with the spacer being positioned between the flat washer and the magnet. After the screw is affixed to the surface, a metal object can be magnetically attached to the screw and magnet to secure the object to the surface. A backer plate is also contemplated for securing non-magnetic objects to the screw and magnet. Multiple backer plates can be affixed to objects to support a greater amount of weight if required.

Abstract: The invention relates to methods of obtaining compositions for generating multipotent hematopoietic stem progenitor cells comprising expansion of hematopoietic stem cells in the presence of HDACI and IDM. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention.

Abstract: The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to a human hiwi gene. Also provided are recombinant expression constructs capable of expressing the human hiwi gene of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human hiwi proteins encoded therein. The invention also provides methods for isolating human hematopoietic stem cells.

Abstract: The present disclosure covers compositions and method for the preparation and use of mixtures of adult stem/progenitor cell populations recovered and enriched from specific tissues with very limited attempts for their purification. Such mixtures of cell populations have improved therapeutic effectiveness in the treatment of certain diseases and tissue regeneration treatments over their more purified counterpart cell populations. Such mixtures of cell populations can be cryopreserved for future clinical use.

Abstract: A two-cycle, opposed piston engine with side-mounted crankshafts and cylinders isolated from mechanical stresses of the engine includes tailored cooling of cylinders and symmetrical cooling of the interior surfaces of piston crowns. Each opposed piston includes a compliant member that permits movement of an axially-centered rod mounted in the piston in order to maintain axial alignment with the bore of a cylinder in which the piston is disposed during engine operation. A single wristpin is disposed externally of the piston to connect the piston with connecting rods that run between the piston and the crankshafts.

Abstract: An apparatus for punching and binding a stack of papers is disclosed. The apparatus includes a paper clamp and a binding element insertion device that are movable relative to each other. The binding element insertion device is configured to receive and detect binding elements of different sizes. The apparatus also includes a punching mechanism, a controller, and a user interface. The controller controls movement of the paper clamp and the binding element insertion device based on the size of the binding element needed to bind the stack of papers together. The user interface is configured to provide information to a user of the apparatus and to receive input from the user before, during, and after the punching and binding operation.

Abstract: An apparatus for punching and binding a stack of papers is disclosed. The apparatus includes a paper clamp and a binding element insertion device that are movable relative to each other. The binding element insertion device is configured to receive and detect binding elements of different sizes. The apparatus also includes a punching mechanism, a controller, and a user interface. The controller controls movement of the paper clamp and the binding element insertion device based on the size of the binding element needed to bind the stack of papers together. The user interface is configured to provide information to a user of the apparatus and to receive input from the user before, during, and after the punching and binding operation.

Abstract: An apparatus for punching and binding a stack of papers is disclosed. The apparatus includes a paper clamp and a binding element insertion device that are movable relative to each other. The binding element insertion device is configured to receive and detect binding elements of different sizes. The apparatus also includes a punching mechanism, a controller, and a user interface. The controller controls movement of the paper clamp and the binding element insertion device based on the size of the binding element needed to bind the stack of papers together. The user interface is configured to provide information to a user of the apparatus and to receive input from the user before, during, and after the punching and binding operation.

Abstract: An apparatus for punching and binding a stack of papers is disclosed. The apparatus includes a paper clamp and a binding element insertion device that are movable relative to each other. The binding element insertion device is configured to receive and detect binding elements of different sizes. The apparatus also includes a punching mechanism, a controller, and a user interface. The controller controls movement of the paper clamp and the binding element insertion device based on the size of the binding element needed to bind the stack of papers together. The user interface is configured to provide information to a user of the apparatus and to receive input from the user before, during, and after the punching and binding operation.

Abstract: An apparatus for punching and binding a stack of papers is disclosed. The apparatus includes a paper clamp and a binding element insertion device that are movable relative to each other. The binding element insertion device is configured to receive and detect binding elements of different sizes. The apparatus also includes a punching mechanism, a controller, and a user interface. The controller controls movement of the paper clamp and the binding element insertion device based on the size of the binding element needed to bind the stack of papers together. The user interface is configured to provide information to a user of the apparatus and to receive input from the user before, during, and after the punching and binding operation.

Abstract: The invention relates to methods of obtaining compositions for generating multipotent hematopoietic stem progenitor cells comprising expansion of hematopoietic stem cells in the presence of HDACI and IDM. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention.