Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: A work sheet support apparatus for greatly reducing and/or eliminating vaporized waste material deposits on a tooling plate during laser cutting of a work piece from various types of thin sheet material. The support apparatus allows for air flow in and around a newly cut surface in the work sheet. The air flow helps condense the vaporized material cut by a laser beam onto the sides of a plurality of holes in the support apparatus and preventing the waste material from depositing on the tooling plate. The apparatus includes a frame with one side having a scale corresponding to a "X" axis and an adjacent side having a scale corresponding to a "Y" axis. The support apparatus further includes a perforated housing, such as a honeycomb structure, having a plurality of holes therethrough for allowing air circulation in and around a newly cut surface of the work piece. The apparatus also includes legs on the bottom of corners of the frame for holding the apparatus above a flat surface of the tooling plate.