Abstract: An iontophoretic drug delivery device includes a controller normally being in an off or low power consumption state, and a patch including electrodes, a reservoir containing an ionizable drug for transcutaneous delivery to a patient and a return reservoir. The patch is removably and electrically connectable to the controller, and delivers the drug to patient when the patch is on the patient's skin and when the controller is switched from the off or low power consumption state to an operational state. This occurs when the patch is inserted into the controller. This feature preserves the battery of the controller. Upon patch insertion, the controller periodically changes from a non-current delivery state to a current delivery state for the predetermined period of time to deliver a pulse of current to the inserted patch. A current sensor within the controller measures the current delivered to the patch.

Abstract: An iontophoretic drug delivery system of the present invention includes a disposable patch electrically interconnectible with a controller. The patch includes at least two electrode assemblies, with one of the electrode assemblies having a first electrode and a second electrode. In this way, during delivery of electrical current one of the electrodes is exhausted so that upon an attempt to reuse the patch, the controller does not detect the delivery of electrical current through said electrodes and fails to supply electrical current to the electrode assemblies for delivery of the drug. Electrical interconnection between the patch and the controller is established by inserting a tab extending from the patch into the controller.

Abstract: An iontophoretic drug delivery system including a patch and a controller. The controller and patch include electronics which ensure proper hydration of the patch. If the controller determines that the patch is sufficiently hydrated, the controller applies current to the patch for delivery of the drug through the skin of the patient.

Abstract: An iontophoretic delivery system permits transcutaneous delivery of a drug contained on a patch. The system includes a flexible planar patch having a medicament-containing surface in contact with the skin of a patient. A controller supplies electrical current to effect iontophoretic delivery. Electrical connection is established between the controller and the patch. The connection is maintained free of contaminants which could adversely affect the electrical connection by employing an abrasive wiping surface to clean the electrical interconnection.

Abstract: An iontophoretic system includes a medicament containing disposable patch removably attached to a patient's skin in combination with a controller mechanism. The patch includes an anode and a cathode, and holds an electrolyte and a medicament. The controller includes a controller circuit which is coupled to the cathode and is adjustable to provide a desired current flow through the electrodes to drive the medicament to the skin of the patient. The controller preferably includes a variety of functions to ensure safe and proper delivery of the medicament. The controller circuit is preferably an application specific integrated circuit (ASIC) so as to provide a compact controller having increased reliability and reduced power consumption.

Abstract: An iontophoretic drug delivery device including a reusable controller and patch are disclosed. The controller and patch include electronics which ensure compatibility of the reusable iontophoretic controller with the specific patch to which it is connected. If the controller determines that the patch is incompatible with the controller, the controller does not apply current to the patch.

Abstract: An iontophoretic drug delivery device of the present invention includes a power source and an electrode assembly in electrical contact with at least three reservoirs, with at least two of the reservoirs containing an active formulation to be delivered to an applied area of a patient, with a switch for switching the flow of current from between the first electrode and the third electrode and between the second electrode and the first electrode so as to reduce sensation. The device also includes a timer for controlling the amount of time the electrical current flows between a pair of electrodes. In the preferred embodiment, the active formulation includes a local anesthetic such as Lidocaine and a vasoconstrictor such as Epinephrine. In this way, the device is suitable for use to deliver the local anesthetic to the applied area approximate the first reservoir for a first period of time and to deliver the local anesthetic to the applied area approximate the second reservoir during a second period of time.

Abstract: An iontophoretic delivery system permits transcutaneous delivery of a drug contained on a patch. The system includes a flexible planar patch having a medicament-containing surface in contact with the skin of a patient. A controller supplies electrical current to the patch to effect iontophoretic delivery. Convenient removable attachment of the controller to the patch is provided so as to permit periodic drug administration.

Abstract: An apparatus for noninvasive determination of constituent concentrations utilizing light wave absorption measurements and methods for processing signals generated by such measurements.

Abstract: A multi-wire telephone system which facilitates voice and data communication between any two telephones connected to each other with one of a plurality of standard shielded twisted-pair cables. The telephones, which are battery-powered, feature standard telephone operation without a central switching and control station or PBX. Each telephone is provided with a microprocessor which can generate and decode all signals necessary to establish communication with any other telephone in the system. Since a PBX is not required, a break in any phone line will result in two systems operating independently of each other although somewhat degraded performance can be expected, depending upon the nature of the break. Whenever communication is established between two stations in the system, a direct current bias is impressed on the cable interconnecting those stations such that all other stations in the system can determine that that particular cable is in use and can select another cable for communication.