Patents by Inventor Ronald J. Harkrader

Ronald J. Harkrader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pesticides comprising benzophenanthridine alkaloids
    Patent number: 6277416
    Abstract: The present invention relates to a chemical composition useful in the chemical management of plant disease. The pesticides of the present invention incorporate benzophenanthridine alkaloids into formulations that are (1) residual and active for a period of time, (2) are adhesive to plant surfaces, (3) have good spreading properties, (4) are stable against photodeactivation, (5) have low phytoxicity, and (6) are capable of penetrating plant tissues.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: August 21, 2001
    Assignee: Camas Technologies, Inc.
    Inventors: Ronald J. Harkrader, Donald L. Meyer
  • Free amine benzophenanthridine alkaloid compositions
    Patent number: 5395615
    Abstract: A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: March 7, 1995
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Kenneth C. Godowski, Ronald J. Harkrader, Richard L. Dunn, Arthur J. Tipton
  • Intragingival delivery systems for treatment of periodontal disease
    Patent number: 5324520
    Abstract: A polymeric controlled delivery system is provided for use in treating periodontal disease. The delivery system in a variety of forms is placed directly in the infected gingival tissue where the chemotherapeutic agent is slowly released into the tissue and into the infected periodontal pocket by means of the gingival crevicular fluid originating in the gingival tissue.
    Type: Grant
    Filed: April 13, 1993
    Date of Patent: June 28, 1994
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Richard L. Dunn, Arthur J. Tipton, Ronald J. Harkrader, Jack A. Rogers
  • Free amine benzophenanthridine alkaloid compositions
    Patent number: 5175000
    Abstract: A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: December 29, 1992
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Kenneth C. Godowski, Ronald J. Harkrader, Richard L. Dunn, Arthur J. Tipton
  • Purification of benzophenanthridine alkaloids extracts from alkaloid extracts
    Patent number: 5133981
    Abstract: A method for separating and purifying individual benzophenanthridine alkaloids from alkaloid extracts by using the pH differences in formation of their respective alkanolamine or base forms and iminium ions. The insoluble base form of the alkaloid is collected as a precipitate and dissolved in an organic solvent and converted to the insoluble iminium ion form with a mineral or organic acid.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: July 28, 1992
    Assignee: Atrix Laboratories, Inc.
    Inventors: Ronald J. Harkrader, Richard R. Jones
  • Oral rinse compositions
    Patent number: 5066483
    Abstract: Mouthrinses containing sanguinarine of superior efficacy and increased uptake into dental plaque are attained by the development of stable mouthrinses adjusted to a pH in the range of 4.0 to 5.6, preferably about 4.5. The compositions may contain a zinc salt as an optional ingredient. Various types of buffer systems are described.
    Type: Grant
    Filed: September 17, 1990
    Date of Patent: November 19, 1991
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Ronald J. Harkrader, Richard R. Jones, Kenneth S. Peterson
  • Drug delivery devices
    Patent number: 5013553
    Abstract: Drug delivery devices and techniques are described for use in treatment of periodontal disease and the like. The delivery device includes benzo (c) phenanthridine alkaloid in a bioerodable and biocompatible material. The alkaloid is slowly released from the bioerodable material in the oral cavity. The bioerodable material may be polymeric and may be natural or synthetic. The delivery device may be inserted subgingivally (e.g., in a periodontal pocket) where the alkaloid is released slowly over a period of days.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: May 7, 1991
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: G. Lee Southard, Ronald J. Harkrader
  • Muscosal delivery systems for treatment of periodontal disease
    Patent number: 4975271
    Abstract: A muscosal delivery system is provided for use in treating periodontal disease. The system is composed of a chemotherapeutic agent dissolved in a skin-penetration enhancer. The solution of chemotherapeutic agent and skin-penetration enhancer is placed into the periodontal pocket where the agent is transported into the surrounding gingival tissue by means of the penetration enhancer.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: December 4, 1990
    Assignee: Vipont Pharmaceutical, Inc.
    Inventors: Richard L. Dunn, Kenneth C. Godowski, Ronald J. Harkrader, George L. Southard