Patents by Inventor Ronald J. Hinklin

Ronald J. Hinklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN TYROSINE PHOSPHATASE INHIBITORS
    Publication number: 20240124453
    Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
    Type: Application
    Filed: November 17, 2023
    Publication date: April 18, 2024
    Applicant: Array BioPharma Inc.
    Inventors: James Francis BLAKE, Mark Laurence BOYS, Mark Joseph CHICARELLI, Adam Wade COOK, Mohamed S. A. ELSAYED, Jay Bradford FELL, John P. FISCHER, Ronald Jay HINKLIN, Yutong JIANG, Oren Teague MCNULTY, Macedonio J. MEJIA, Martha E. RODRIGUEZ, Christina Elizabeth WONG
  • PIPERIDINYL-SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS
    Publication number: 20140309226
    Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, in which X1, X2, R3, R4, R5, Rx, R7, R9, R10 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.
    Type: Application
    Filed: November 14, 2012
    Publication date: October 16, 2014
    Inventors: Jay Bradford Fell, John P. Fischer, Ronald J. Hinklin
  • Chemical synthesis of reagents for peptide coupling
    Patent number: 7317129
    Abstract: The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: January 8, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson, Yi He, Matthew B. Soellner, Ronald J. Hinklin
  • Chemical synthesis of reagents for peptide coupling
    Patent number: 6974884
    Abstract: The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: December 13, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson, Yi He, Matthew B. Soellner, Ronald J. Hinklin
  • Chemical synthesis of reagents for peptide coupling
    Publication number: 20040030105
    Abstract: The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
    Type: Application
    Filed: June 6, 2003
    Publication date: February 12, 2004
    Inventors: Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson, Yi He, Matthew B. Soellner, Ronald J. Hinklin