Patents by Inventor Ronald J. Santelli

Ronald J. Santelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Parenteral metolazone formulations
    Patent number: 6048874
    Abstract: The invention provides a method of making a pharmaceutical composition comprising a solution, which method comprises: (a) providing a solvent comprising propylene glycol, polyethylene glycol, polypropylene glycol, or glycerin; and (b) adding metolazone. The final concentration of metolazone in the solution is 9 mg/ml or more, the metolazone is not precipitated, and the concentration of metolazone is above its apparent equilibrium solubility. The invention also provides a pharmaceutical composition comprising a solution comprising: (a) a solvent other than water; and (b) 9 mg/ml or more of metolazone. The metolazone is not precipitated in this solution and the concentration of metolazone is above its apparent equilibrium solubility.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: April 11, 2000
    Assignee: Medeva Pharmaceuticals Manufacturing, Inc.
    Inventors: Ronald J. Santelli, Yu-Hsing Tu