Patents by Inventor Ronald J. Sapolsky

Ronald J. Sapolsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030032025
    Abstract: The invention provides oligonucleotides and their complements that can be used as allele-specific probes or primers for sequencing, oligonucleotide probe hybridization, and allele-specific amplification. Such oligonucleotides can be used, for example, to facilitate genetic distinction between individual plants in plant populations.
    Type: Application
    Filed: January 9, 2002
    Publication date: February 13, 2003
    Applicant: Affymetrix, Inc.
    Inventors: Bertrand Lemieux, Benoit S. Landry, Ronald J. Sapolsky, Alain Murigneux
  • Patent number: 6509160
    Abstract: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: January 21, 2003
    Assignee: Affymetric, Inc.
    Inventors: Ronald J. Sapolsky, Robert J. Lipshutz, Thomas R. Gingeras
  • Publication number: 20030008292
    Abstract: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction-sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
    Type: Application
    Filed: August 27, 2001
    Publication date: January 9, 2003
    Inventors: Ronald J. Sapolsky, Robert J. Lipshutz, Thomas R. Gingeras
  • Patent number: 6358686
    Abstract: The invention provides oligonucleotides and their complements that can be used as allele-specific probes or primers for sequencing, oligonucleotide probe hybridization, and allele-specific amplification. Such oligonucleotides can be used, for example, to facilitate genetic distinction between individual plants in plant populations.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: March 19, 2002
    Assignee: Affymetrix, Inc.
    Inventors: Bertrand Lemieux, Benoit S. Landry, Ronald J. Sapolsky
  • Patent number: 6291181
    Abstract: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: September 18, 2001
    Assignee: Affymetrix, Inc.
    Inventors: Ronald J. Sapolsky, Robert J. Lipshutz, Thomas R. Gingeras
  • Patent number: 6114116
    Abstract: The invention provides oligonucleotides and their complements that can be used as allele-specific probes or primers for sequencing, oligonucleotide probe hybridization, and allele-specific amplification. Such oligonucleotides can be used, for example, to facilitate genetic distinction between individual plants in plant populations.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: September 5, 2000
    Inventors: Bertrand Lemieux, Benoit S. Landry, Ronald J. Sapolsky
  • Patent number: 6027894
    Abstract: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the "capturing" and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: February 22, 2000
    Assignee: Affymetrix, Inc.
    Inventors: Ronald J. Sapolsky, Robert J. Lipshutz, Thomas R. Gingeras
  • Patent number: 5858659
    Abstract: The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, e.g., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: January 12, 1999
    Assignee: Affymetrix, Inc.
    Inventors: Ronald J. Sapolsky, Robert J. Lipshutz
  • Patent number: 5710000
    Abstract: The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the "capturing" and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 20, 1998
    Assignee: Affymetrix, Inc.
    Inventors: Ronald J. Sapolsky, Robert J. Lipshutz, Thomas R. Gingeras