Patents by Inventor Ronald J. Tuch
Ronald J. Tuch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7811317Abstract: A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.Type: GrantFiled: October 30, 2007Date of Patent: October 12, 2010Assignee: Medtronic, Inc.Inventors: Eric P. Berg, Ronald J. Tuch, Michael Dror, Rodney G. Wolff
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Publication number: 20080275544Abstract: A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.Type: ApplicationFiled: October 30, 2007Publication date: November 6, 2008Applicant: Medtronic, Inc.Inventors: Eric P. Berg, Ronald J. Tuch, Michael Dror, Rodney G. Wolff
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Patent number: 7419696Abstract: A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.Type: GrantFiled: November 30, 2005Date of Patent: September 2, 2008Assignee: Medtronic, Inc.Inventors: Eric P. Berg, Ronald J. Tuch, Michael Dror, Rodney G. Wolff
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Patent number: 6997949Abstract: A device useful for localized delivery of a therapeutic agent is provided. The device includes a structure including a porous polymeric material and an elutable therapeutic agent in the form of a solid, gel, or neat liquid, which is dispersed in at least a portion of the porous polymeric material. Methods for making a medical device having a blood-contacting surface is also provided. One method involves: providing a structure comprising a porous material; contacting the structure comprising a porous material with a concentrating agent to disperse the concentrating agent throughout at least a portion of the porous material; contacting the structure comprising a porous material and the concentrating agent with a solution of a therapeutic agent; and removing the therapeutic agent from solution within the porous material at the locations of the concentrating agent. Another method involves multiple immersion steps without the use of a concentrating agent.Type: GrantFiled: May 20, 2002Date of Patent: February 14, 2006Assignee: Medtronic, Inc.Inventor: Ronald J. Tuch
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Publication number: 20020138048Abstract: A device useful for localized delivery of a therapeutic agent is provided. The device includes a structure including a porous polymeric material and an elutable therapeutic agent in the form of a solid, gel, or neat liquid, which is dispersed in at least a portion of the porous polymeric material. Methods for making a medical device having a blood-contacting surface is also provided. One method involves: providing a structure comprising a porous material; contacting the structure comprising a porous material with a concentrating agent to disperse the concentrating agent throughout at least a portion of the porous material; contacting the structure comprising a porous material and the concentrating agent with a solution of a therapeutic agent; and removing the therapeutic agent from solution within the porous material at the locations of the concentrating agent. Another method involves multiple immersion steps without the use of a concentrating agent.Type: ApplicationFiled: May 20, 2002Publication date: September 26, 2002Inventor: Ronald J. Tuch
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Publication number: 20020055710Abstract: A device useful for localized delivery of a therapeutic agent is provided. The device includes a structure including a porous polymeric material and an elutable therapeutic agent in the form of a solid, gel, or neat liquid, which is dispersed in at least a portion of the porous polymeric material. Methods for making a medical device having a blood-contacting surface is also provided. One method involves: providing a structure comprising a porous material; contacting the structure comprising a porous material with a concentrating agent to disperse the concentrating agent throughout at least a portion of the porous material; contacting the structure comprising a porous material and the concentrating agent with a solution of a therapeutic agent; and removing the therapeutic agent from solution within the porous material at the locations of the concentrating agent. Another method involves multiple immersion steps without the use of a concentrating agent.Type: ApplicationFiled: April 30, 1998Publication date: May 9, 2002Inventor: RONALD J. TUCH
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Patent number: 5865814Abstract: A a blood-contacting medical device with improved biocompatibility. The device is coated with a layer of water-soluble heparin, overlaid by a porous polymeric coating through which the heparin can elute. The inclusion of a porous polymer in intimate contact with a heparin on the device controls the administration of heparin following implantation or other blood contact. The adhesion of the coating and the rate at which the heparin is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer.Type: GrantFiled: August 6, 1997Date of Patent: February 2, 1999Assignee: Medtronic, Inc.Inventor: Ronald J. Tuch
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Patent number: 5837008Abstract: A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.Type: GrantFiled: April 27, 1995Date of Patent: November 17, 1998Assignee: Medtronic, Inc.Inventors: Eric P. Berg, Ronald J. Tuch, Michael Dror, Rodney G. Wolff
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Patent number: 5824048Abstract: A method for delivering a therapeutic substance to a body lumen utilizing an intravascular stent having a coating comprising a polymer and a therapeutic substance in a solid/solid solution with the polymer. The coating comprises a first coating layer nearer the stent body having a first concentration of therapeutic substance overlaid by a second porous coating layer having a second lesser concentration of therapeutic substance. The inclusion of a porous polymer coating layer on the stent helps retain the therapeutic substance on the stent during expansion of the stent and also controls the administration of the therapeutic substance following implantation. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.Type: GrantFiled: October 9, 1996Date of Patent: October 20, 1998Assignee: Medtronic, Inc.Inventor: Ronald J. Tuch
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Patent number: 5820917Abstract: A method for making a blood-contacting medical device with improved biocompatibility by applying to the blood-contacting surface an aqueous solution of heparin and then overcoating the heparin with a porous polymer. The inclusion of a porous polymer in intimate contact with a heparin on the device controls the administration of heparin following implantation or other blood contact. The adhesion of the coating and the rate at which the heparin is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer.Type: GrantFiled: June 7, 1995Date of Patent: October 13, 1998Assignee: Medtronic, Inc.Inventor: Ronald J. Tuch
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Patent number: 5776184Abstract: A device for delivery of a therapeutic substance into a body lumen including a polymer in intimate contact with a drug on a stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer.Type: GrantFiled: October 9, 1996Date of Patent: July 7, 1998Assignee: Medtronic, Inc.Inventor: Ronald J. Tuch
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Patent number: 5697967Abstract: An intraluminal stent comprising fibrin and an elutable drug is capable of providing a treatment of restenosis.Type: GrantFiled: April 27, 1995Date of Patent: December 16, 1997Assignee: Medtronic, Inc.Inventors: Thomas Q. Dinh, Ronald J. Tuch, Robert S. Schwartz
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Patent number: 5679400Abstract: A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.Type: GrantFiled: June 7, 1995Date of Patent: October 21, 1997Assignee: Medtronic, Inc.Inventor: Ronald J. Tuch
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Patent number: 5624411Abstract: A method for making an intravascular stent by applying to the body of a stent a therapeutic substance and then overcoating the therapeutic substance with a porous polymer. The inclusion of a porous polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer.Type: GrantFiled: June 7, 1995Date of Patent: April 29, 1997Assignee: Medtronic, Inc.Inventor: Ronald J. Tuch
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Patent number: 5599352Abstract: An intraluminal stent comprising fibrin and an elutable drug is capable of providing a treatment of restenosis.Type: GrantFiled: September 15, 1994Date of Patent: February 4, 1997Assignee: Medtronic, Inc.Inventors: Thomas Q. Dinh, Ronald J. Tuch, Robert S. Schwartz
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Patent number: 5591227Abstract: An intraluminal stent comprising fibrin and an elutable drug is capable of providing a treatment of restenosis.Type: GrantFiled: April 27, 1995Date of Patent: January 7, 1997Assignee: Medtronic, Inc.Inventors: Thomas Q. Dinh, Ronald J. Tuch, Robert S. Schwartz
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Patent number: 5510077Abstract: An intraluminal stent comprising fibrin treatment of restenosis is provided by a two stage molding process.Type: GrantFiled: September 15, 1994Date of Patent: April 23, 1996Inventors: Thomas Q. Dinh, Ronald J. Tuch, Michael Dror
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Patent number: 5464650Abstract: A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.Type: GrantFiled: April 26, 1993Date of Patent: November 7, 1995Assignee: Medtronic, Inc.Inventors: Eric P. Berg, Ronald J. Tuch, Michael Dror, Rodney G. Wolff