Abstract: A microencapsulated pharmaceutical is formed by vapor depositing a polymeric film about an active pharmaceutical agent. The film thickness of the vapor deposited film is controlled to provide effective controlled release of said pharmaceutical agent subsequent to application. In a preferred embodiment the pharmaceutical is an orally ingestible pharmaceutical formed by vapor deposition of a poly-p-xylylene polymer about a core comprising an active pharmaceutical agent. The pharmaceutical agent exhibits surprising controlled release activity inspite of the extreme inertness of vapor deposited films such as Parylene films.

Abstract: A microencapsulated pharmaceutical is formed by vapor depositing a polymeric film about an active pharmaceutical agent. The film thickness of the vapor deposited film is controlled to provide effective controlled release of said pharmaceutical agent subsequent to application. In a preferred embodiment the pharmaceutical is an orally ingestible pharmaceutical formed by vapor deposition of a poly-p-xylylene polymer about a core comprising an active pharmaceutical agent. The pharmaceutical agent exhibits surprising controlled release activity inspite of the extreme inertness of vapor deposited films such as Parylene films.

Abstract: Tamper-indicating, laminated wrappers wherein a visible change between layers of the wrapper indicate that the wrapper has been punctured or that there has been tampering with the wrapper or its contents. The wrapper may be composed of two or more plies of packaging material such as films made from ethylene vinyl alcohol copolymer or from polyolefins such as polypropylene. In one construction, a transparent or translucent laminated wrapper becomes opaque upon rupture or puncture. In other constructions, a transparent or translucent wrapper becomes colored at the site of the rupture or puncture.

Abstract: Microcapsules having a high loading factor of core material are formed as separate, reservoir microcapsules by coating solid core particles first with a thin, conformal layer of parylene and then with a layer of thermoplastic material.

Abstract: This invention relates to fuel granules of lithium having multiple coatings thereon and to the method of making the coated granules.

Abstract: A method and apparatus for microencapsulating an electroluminescent phosphor with an extremely thin coating. The process involves vaporizing a poly-para-xylylene, pyrolyzing the resulting vapors to form reactive monomeric radicals, and then passing such vaporous radicals to a vacuum deposition zone where they contact tumbling particles of an electroluminescent phosphor under vacuum conditions. As the particles are being coated, they are sifted by means of a screen. The reactive monomeric radicals deposit on the tumbling particles, are adsorbed by the particles, and polymerized into a very thin coating on the surfaces of the particles.