Patents by Inventor Ronald J. Wysocki

Ronald J. Wysocki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8389728
    Abstract: This disclosure relates, inter alia, to stimulants of pollen tube germination and growth of pollen tubes, and methods of their use to stimulate in vitro and in vivo pollen germination and pollen tube growth.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: March 5, 2013
    Assignee: The Arizona Board of Regents
    Inventors: Yuan Qin, Ravishankar Palanivelu, Ronald J. Wysocki, Jr., Arpad Somogyi, Yelena Feinstein
  • Publication number: 20110111959
    Abstract: This disclosure relates, inter alia, to stimulants of pollen tube germination and growth of pollen tubes, and methods of their use to stimulate in vitro and in vivo pollen germination and pollen tube growth.
    Type: Application
    Filed: March 26, 2010
    Publication date: May 12, 2011
    Inventors: Yuan Qin, Ravishankar Palanivelu, Ronald J. Wysocki, JR., Arpad Somogyi, Yelena Feinstein
  • Patent number: 5981524
    Abstract: Optically active or racemic compounds represented by the formula ##STR1## where R.sub.1 is C.sub.1 to C.sub.4 straight chain or branched alkyl; R.sub.2 is selected from the group consisting of H, --OR.sub.1, --SR.sub.1, --NH(R.sub.1), --N(R.sub.4)(R.sub.5), aminocarbonyl, halogen, and --CN, where R.sub.4 and R.sub.5 are independently C.sub.1 to C.sub.6 straight chain or branched alkyl, or taken together form a 3- to 7-membered heterocycloalkyl substituent, such heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, optionally including an additional heteroatom which is selected from the group consisting of nitrogen, oxygen, and sulfur; R.sub.3 is cyclopentyl or: ##STR2## where R' and R" are independently H, .dbd.O, --OH, or --NH.sub.2, with the proviso that R' and R" can be taken together form the following structure as R.sub.3 : ##STR3## where R'" is --OH or --NH.sub.2 ; and with the further proviso that when R.sub.3 is cyclopentyl or norbornyl, then R.sub.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: November 9, 1999
    Assignee: Discovery Therapeutics, Inc.
    Inventors: James V. Peck, Ronald J. Wysocki, Ibrahim M. Uwaydah, Noel J. Cusack
  • Patent number: 5817799
    Abstract: A method of preparing a 2'-fluoro compound of the formula ##STR1## where B is selected from the group consisting of purines and pyrimidines, both of which may be substituted, comprises reacting a compound of the formula II(a) or II(b) ##STR2## where R and R' are as defined in the specification with an acid halide under conditions effective to obtain a halide of the formula ##STR3## where X is a halogen. A silane of the formula B-Si (R").sub.3 where R" is as defined in the specification, is added to this product (III) under conditions effective to obtain a compound of the formula (IV) ##STR4## The compound of formula (IV) is reacted with a reagent selected from the group consisting of ammonia, BCl.sub.3 and ((C.sub.1 -C.sub.10)alkyl).sub.4 NF, under conditions effective to obtain the compound of formula (I). The compounds of formula (I) resulting from these methods exhibit anti-HIV activities and are useful for therapy against the HIV virus.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: October 6, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Victor E. Marquez, John S. Driscoll, Ronald J. Wysocki, Jr., Magbool A. Siddiqui
  • Patent number: 5670501
    Abstract: Optically active or racemic compounds represented by the formula ##STR1## where R.sub.1 is C.sub.1 to C.sub.4 straight chain or branched alkyl; R.sub.2 is selected from the group consisting of H, --OR.sub.1, --SR.sub.1, --NH(R.sub.1), --N(R.sub.4)(R.sub.5), aminocarbonyl, halogen, and --CN, where R.sub.4 and R.sub.5 are independently C.sub.1 to C.sub.6 straight chain or branched alkyl, or taken together form a 3- to 7-membered heterocycloalkyl substituent, such heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, optionally including an additional heteroatom which is selected from the group consisting of nitrogen, oxygen, and sulfur; R.sub.3 is cyclopentyl or: ##STR2## where R' and R" are independently H, .dbd.O, --OH, or --NH.sub.2, with the proviso that R' and R" can be taken together form the following structure as R.sub.3 : ##STR3## where R'" is --OH or --NH.sub.2 ; and with the further proviso that when R.sub.3 is cyclopentyl or norbornyl, then R.sub.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: September 23, 1997
    Assignee: Discovery Therapeutics, Inc.
    Inventors: James V. Peck, Ronald J. Wysocki, Ibrahim M. Uwaydah, Noel J. Cusack
  • Patent number: 5336764
    Abstract: A compound has the formula ##STR1## wherein R is selected from the group consisting of (C.sub.7 -C.sub.20)aroyl, (C.sub.6 -C.sub.20)aryl, aralkyl and alkylaryl, and (C.sub.1 -C.sub.10)alkyl-di(C.sub.6 -C.sub.20)aryl Si, R' is selected from the group consisting of (C.sub.1 -C.sub.10)alkyl, (C.sub.7 -C.sub.20)aroyl and (C.sub.2 -C.sub.12)acyl, all of which may be further substituted with O, S, N or alkyl, and R'" is selected from the group consisting of halogen, (C.sub.1 -C.sub.10)alkoxy, (C.sub.1 -C.sub.10)acyloxy, O-methane-sulfonyl and O-p-toluenesulfonyl. A composition of matter comprises 0.001 to 99.999 wt % of the above compound.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: August 9, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Victor E. Marquez, John S. Driscoll, Ronald J. Wysocki, Jr., Maqbool A. Siddiqui