Abstract: Timing adjustment for accurate zero-crossing determination includes obtaining time offset(s) representing amounts of time between (i) zero-crossings of an input signal waveform, representative of an input AC waveform, input to a zero-crossing detector circuit and (ii) corresponding transitions of an output signal from an output of the circuit to a microcontroller, and determining times of the zero-crossings of the input AC waveform, which includes determining times of the corresponding transitions as detected by the microcontroller and adjusting the determined times using the time offset(s) to produce the times of the zero-crossings of the input AC waveform. In another aspect, input AC frequency is determined by determining pulse width(s) of pulse(s) of the output signal, and adjusting a half-cycle time corresponding to the pulse width(s) using the time offset(s) to provide a duration of half-cycles of the input AC waveform and inform a frequency of the input AC waveform.

Abstract: In accordance with an embodiment of the disclosure, a system includes a combustor liner disposed about a combustion chamber of a combustor of a gas turbine system. The combustor liner includes an inner wall portion exposed to the combustion chamber, an outer wall portion disposed about the inner wall portion, and multiple channels between the inner and outer wall portions of the combustor liner. Each channel of the multiple channels is configured to direct a coolant along the combustor liner to convectively cool the combustor liner, and each channel of the multiple channels includes a cross-sectional area that progressively changes along a length of each channel of the plurality of channels.

Abstract: A humidifier includes a heating element including a porous structure of electrically resistive and thermally conductive material configured to substantially vaporise liquid that is passed through the porous structure. The porous structure has a liquid inlet and a vapour outlet. The humidifier further includes an outer housing surrounding at least a portion of the porous structure for containing the liquid and vapour within the porous structure. The porous structure includes a first electrical connector and a second electrical connector, the first and second connectors being configured for receiving electrical power and applying a voltage across the porous structure to generate heat.

Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: A humidifier for humidification of air to be delivered to a patient's airways may include a humidification chamber, a reservoir and a water delivery mechanism. The humidification chamber may include a water retention feature such as a wick, a heating element for heating the humidification chamber, and an air flow baffle configured to promote humidification. The humidifier may be further configured to execute one or more algorithms, for example to determine a condition of the humidifier and/or to mitigate any detected faults. In some forms, the humidifier may also comprise algorithms for controlling one or more components of the humidifier.

Abstract: A humidifier tub for a respiratory apparatus is configured to deliver pressurized breathable gas to a patient's airways. The humidifier tub includes a base and a side wall defining a reservoir for containing a supply of liquid to be evaporated. In addition, the container is made of a first material. The humidifier tub also includes a heating element provided inside the container and covered by a layer. The layer includes a second material different from the first material.

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

Abstract: A method, system and computer program for enabling a loyalty system to be linked to one or more card issuers, cardholders, merchants, and thereby their cardholders. A system operable to create, implement and manage one or more loyalty programs that provide benefits to members of the loyalty programs in connection with transactions between the members and one or more merchants associated with the loyalty system. The method includes registering on the loyalty system one or more card issuers; one or more merchant acquirers associated with the one or more card issuers; a plurality of cardholders as members of the loyalty program. Establishing and applying rules for accrual and processing of benefits from the merchants to cardholders associated with the one or more card issuers in connection with transactions between the cardholders and the merchants with the loyalty system. Defining a rule based survey utility operable to issue surveys to members of the loyalty system on a transaction and non-transaction basis.

Abstract: A PAP system for delivering breathable gas to a patient includes a flow generator to generate a supply of breathable gas to be delivered to the patient; a humidifier including a heating plate to vaporize water and deliver water vapor to humidify the supply of breathable gas; a heated tube configured to heat and deliver the humidified supply of breathable gas to the patient; a power supply configured to supply power to the heating plate and the heated tube; and a controller configured to control the power supply to prevent overheating of the heating plate and the heated tube.

Abstract: A system and method for implementing and manufacturing a hierarchy system for use with a TMCCC-containing electrically-conductive structure (e.g., an electrode) as well as methods for use and manufacturing of such structures and electrochemical cells including these devices. Structures and methods include a coordination complex having LxMyNzTia1Va2Cra3Mna4Fea5Coa6Nia7Cua8Zna9Caa10Mga11[R(CN)6]b (H2O)c;. The method includes binding electrochemically active material to produce a hierarchical structure, the hierarchical structure having a plurality of primary crystallites having a size D1, the plurality of these primary crystallites agglomerated into a set of agglomerates each agglomerate having a size D2>D1.

Abstract: A system and method for implementing and manufacturing a hierarchy system for use with a TMCCC-containing electrically-conductive structure (e.g., an electrode) as well as methods for use and manufacturing of such structures and electrochemical cells including these devices. Structures and methods include a coordination complex having LxMyNzTia1Va2Cra3Mna4Fea5Coa6Nia7Cua8Zna9Caa10Mga11[R(CN)6]b (H2O)c. The method includes binding electrochemically active material to produce a hierarchical structure, the hierarchical structure having a plurality of primary crystallites having a size D1, the plurality of these primary crystallites agglomerated into a set of agglomerates each agglomerate having a size D2>D1.

Abstract: Operating an electrical load controller includes, in one aspect, detecting zero-crossings of an AC waveform, determining periods each corresponding to a full cycle of the AC waveform, determining a frequency of the AC waveform based on the determined periods, and controlling a supply of AC power to a load based thereon using the determined frequency to fire a switching circuit of the electrical load controller.

Abstract: A system and method for implementing and manufacturing a hierarchy system for use with a TMCCC-containing electrically-conductive structure (e.g., an electrode) as well as methods for use and manufacturing of such structures and electrochemical cells including these devices. Structures and methods include a coordination complex having LxMyNzTia1Va2Cra3Mna4Fea5Coa6Nia7Cua8Zna9Caa10Mga11[R(CN)6]b (H2O)c. The method includes binding electrochemically active material to produce a hierarchical structure, the hierarchical structure having a plurality of primary crystallites having a size D1, the plurality of these primary crystallites agglomerated into a set of agglomerates each agglomerate having a size D2>D1.

Abstract: A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises an integrated humidifier including a water reservoir. An RPT device is also disclosed that includes a wireless data communication interface integrated with the housing and configured to connect to another device or a network.

Abstract: The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

Abstract: A humidifier includes a heating element including a porous structure of electrically resistive and thermally conductive material configured to substantially vaporise liquid that is passed through the porous structure. The porous structure has a liquid inlet and a vapour outlet. The humidifier further includes an outer housing surrounding at least a portion of the porous structure for containing the liquid and vapour within the porous structure. The porous structure includes a first electrical connector and a second electrical connector, the first and second connectors being configured for receiving electrical power and applying a voltage across the porous structure to generate heat.

Abstract: A respiratory apparatus is configured to deliver breathable gas to a patient's airways and includes a flow generator configured to pressurize the breathable gas and a humidifier configured to vaporize water and deliver water vapor to humidify the breathable gas. The respiratory apparatus further includes a gas flow path leading from the flow generator to the humidifier and from the humidifier to a patient interface. A continuous heater is positioned within the gas flow path and includes multiple separately controllable heating zones.

Abstract: A connection assembly for a respiratory therapy system, comprising: an outlet assembly, said outlet assembly including an outlet housing and a swivelling disc located on said outlet housing, said outlet housing and said swivelling disc defining, at least in part, a recess; an outlet connector located at an end of a tube portion, said outlet connector including an electrical connector; and a cable having a first end to connect to the electrical connector and a second end to connect to at least one electrical component of the respiratory therapy system, said cable having a slack portion, wherein said outlet connector and said swivelling disc are rotatable in unison between a first position and a second position, and wherein the slack portion of the cable extends from the recess and wraps around the swivelling disc as the swivelling disc is rotated from the first position to the second position.

Abstract: A heated conduit is configured to connect to and receive pressurized breathable gas from a respiratory unit. The heated conduit includes a first cuff that includes an air inlet portion and an electrical connector portion that is adjacent the air inlet portion and comprises three electrical terminals that are configured to engage a respiratory unit electrical connector. The heated conduit also includes a second cuff comprising an air outlet and a flexible tube portion with a first end connected to the first cuff, a second end connected to the second cuff, and a spiral rib structure wrapped around a central lumen. A grouping of wires is supported within the spiral rib structure of the flexible tube portion and include a pair of heating wires and a signal wire. A sensing device extends into the gas flow path from an interior surface of the second cuff and is configured to output a signal indicative of the condition inside the heated conduit.