Patents by Inventor Ronald Keith Webber

Ronald Keith Webber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6787668
    Abstract: The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of H and methyl; and R2 is selected from the group consisting of H and methyl. The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: September 7, 2004
    Assignee: Pharmacia Corporation
    Inventors: Barnett S. Pitzele, James A. Sikorski, Ronald Keith Webber
  • Pyrrolo[1,2-b][1,2,4]oxadiazine diones useful as nitric oxide synthase inhibitors
    Patent number: 6774126
    Abstract: Pyrrolo[1,2-b][1,2,4]oxadiazine-2,3(6H)-diones having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: August 10, 2004
    Assignee: Pharmacia Corporation
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Alok K. Awasthi, Suzanne Metz, Jeffrey A. Scholten, Jeffery S. Snyder, Mihaly V. Toth, Ronald Keith Webber
  • 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6756406
    Abstract: The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: September 15, 2001
    Date of Patent: June 29, 2004
    Assignee: Pharmacia Corporation
    Inventors: Richard C. Durley, James Sikorski, Donald W. Hansen, Jr., Michelle A. Promo, Ronald Keith Webber, Barnett S. Pitzele, Alok K. Awasthi, Alan Moorman
  • Pyrrolo[1,2-b][1,2,4]oxadiazine diones useful as nitric oxide synthase inhibitors
    Publication number: 20040019019
    Abstract: The current invention discloses useful bicyclic and tricyclic amidino derivative compounds, pharmaceutical compositions containing these novel compounds, and to their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: October 7, 2002
    Publication date: January 29, 2004
    Inventors: Donald W. Hansen, E. Ann Hallinan, Alok K. Awasthi, Suzanne Metz, Jeffrey A. Scholten, Jeffery S. Snyder, Mihaly V. Toth, Ronald Keith Webber
  • Methods of making amidino compounds useful as nitric oxide synthase inhibitors
    Publication number: 20030199701
    Abstract: A method of making an alpha-amino acid compound having the structure of Formula 32: 1
    Type: Application
    Filed: December 17, 2002
    Publication date: October 23, 2003
    Applicant: Pharmacia Corporate
    Inventors: Ronald Keith Webber, Richard C. Durley, Alok K. Awasthi, Arija A. Bergmanis, Kam F. Fok, Scott S. Ganser, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Brian S. Hickory, Pamela T. Manning, Michael Mao, Alan E. Moormann, Barnett S. Pitzele, Michelle A. Promo, Richard R. Schartman, Jeffrey A. Scholten, Jeffrey S. Snyder, Mihaly V. Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Siong Tjoeng
  • Amidino compounds useful as nitric oxide synthase inhibitors
    Patent number: 6586474
    Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: July 1, 2003
    Assignee: Pharmacia Corporation
    Inventors: Ronald Keith Webber, Richard C. Durley, Alok K. Awasthi, Arija A. Bergmanis, Kam F. Fok, Scott S. Ganser, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Brian S. Hickory, Pamela T. Manning, Michael Mao, Alan E. Moormann, Barnett S. Pitzele, Michelle A. Promo, Richard R. Schartman, Jeffrey A. Scholten, Jeffrey S. Snyder, Mihaly V. Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Siong Tjoeng
  • Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6586471
    Abstract: The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: July 1, 2003
    Assignee: G. D. Searle
    Inventors: Donald W. Hansen, Jr., Barnett S. Pitzele, Ronald Keith Webber, Mihaly V. Toth, Pamela T. Manning, Alok K. Awasthi, Mahima Trivedi
  • 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6545170
    Abstract: The present invention contains novel compounds useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: April 8, 2003
    Assignee: Pharmacia Corporation
    Inventors: Barnett S. Pitzele, James A. Sikorski, Donald W. Hansen, Jr., Ronald Keith Webber, Mihaly V. Toth, Jeffrey A. Scholten, Jeffrey S. Snyder
  • Homoiminopiperidinyl hexanoic acid inhibitors of inducible nitric oxide synthase
    Patent number: 6495544
    Abstract: Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: December 17, 2002
    Assignee: Pharmacia Corporation
    Inventors: Donald W. Hansen, Jr., Jeffrey S. Snyder, Alan E. Moormann, Alok K. Awasthi, Ronald Keith Webber, Thaddeus S. Franczyk, Mahima Trivedi
  • Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6465518
    Abstract: The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: October 15, 2002
    Assignee: Pharmacia Corporation
    Inventors: Donald W. Hansen, Jr., Ronald Keith Webber, Alok K. Awasthi, Pamela T. Manning
  • 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020143061
    Abstract: The present invention contains novel compounds useful as nitric oxide synthase inhibitors.
    Type: Application
    Filed: April 16, 2001
    Publication date: October 3, 2002
    Inventors: Barnett S. Pitzele, James A. Sikorski, Donald W. Hansen, Ronald Keith Webber, Mihaly V. Toth, Jeffrey A. Scholten, Jeffrey S. Snyder
  • 2-Amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020132849
    Abstract: The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: September 15, 2001
    Publication date: September 19, 2002
    Inventors: Donald W. Hansen, Ronald Keith Webber, Barnett S. Pitzele, James Sikorski, Mark A. Massa, Timothy J. Hagen, Margaret Grapperhaus, Lijuan Jane Wang, Arija A. Bergmanis, Steven W. Kramer, E. Ann Hallinan
  • 2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020128510
    Abstract: The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: September 15, 2001
    Publication date: September 12, 2002
    Inventors: Richard C. Durley, James Sikorski, Donald W. Hansen, Michelle A. Promo, Ronald Keith Webber, Barnett S. Pitzele, Alok K. Awasthi, Alan Moorman
  • Homoiminopiperidinyl hexanoic acid inhibitors of inducible nitric oxide synthase
    Publication number: 20020119964
    Abstract: Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.
    Type: Application
    Filed: August 1, 2001
    Publication date: August 29, 2002
    Inventors: Donald W. Hansen, Jeffrey S. Snyder, Alan E. Moormann, Alok K. Awasthi, Ronald Keith Webber, Thaddeus S. Franczyk, Mahima Trivedi
  • Amidino compounds useful as nitric oxide synthase inhibitors
    Publication number: 20020111493
    Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
    Type: Application
    Filed: March 23, 2001
    Publication date: August 15, 2002
    Inventors: Ronald Keith Webber, Alok K. Awasthi, Arija A. Bergmanis, Richard C. Durley, Kam F. Fok, Scott S. Ganser, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Brian S. Hickory, Pamela T. Manning, Michael Mao, Alan E. Moormann, Barnett S. Pitzele, Michelle A. Promo, Richard R. Schartman, Jeffrey A. Scholten, Jeffrey S. Snyder, Mihaly V. Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Siong Tjoeng
  • 2-Amino-2-alky-4 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020103398
    Abstract: The present invention relates to 2-amino-2-alkyl-4 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: September 15, 2001
    Publication date: August 1, 2002
    Inventors: Donald W. Hansen, Mahima Trivedi, Mihaly V. Toth, Ronald Keith Webber, Barnett S. Pitzele, Alok K. Awasthi, James Sikorski
  • 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020077363
    Abstract: The present invention contains novel compounds useful as nitric oxide synthase inhibitors.
    Type: Application
    Filed: April 13, 2001
    Publication date: June 20, 2002
    Inventors: Barnett S. Pitzele, James A. Sikorski, Ronald Keith Webber
  • 2-amino-2-alkyl-3 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020072630
    Abstract: The present invention relates to 2-amino-2-alkyl-3 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors
    Type: Application
    Filed: September 15, 2001
    Publication date: June 13, 2002
    Inventors: Donald W. Hansen, Ronald Keith Webber, Barnett S. Pitzele, Alok K. Awasthi, James Sikorski, Mahima Trivedi
  • 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
    Publication number: 20020072542
    Abstract: The present invention contains novel compounds useful as nitric oxide synthase inhibitors.
    Type: Application
    Filed: April 13, 2001
    Publication date: June 13, 2002
    Inventors: Barnett S. Pitzele, James A. Sikorski, Ronald Keith Webber
  • 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020072631
    Abstract: The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: September 15, 2001
    Publication date: June 13, 2002
    Inventors: Donald W. Hansen, Ronald Keith Webber