Abstract: The present invention relates to cyclic guanidines, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

Abstract: The present invention relates to substituted benzimidazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

Abstract: The present invention relates to substituted indoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus and related conditions.

Abstract: A message to be displayed is sent to the display device from an onboard processor, having been retrieved from memory. The message comes on with the automotive brake lights and remains on until the brakes are released. The message changes with each application of the brake lights and is a continuous loop of sequentially displayed messages. In an alternative embodiment, the display remains on in a dimmer mode until the next application of the brakes changes the message. Thus, the message may be displayed while brake lights are energized, or alternatively, once brake lights are extinguished the message goes to a tail light mode having a reduced illumination level, for example, half as bright.

Abstract: A manufactured metal member, such as a wire, having a magnetite oxide film thereon, is subjected to mechanical stress to produce cracking of the magnetite film approximately to the surface of the metal member. The metal member is then moved through an electrolysis cell bath in which the metal member forms the anode thereof, and vertically positioned steel bars form the cathode. A pulsating DC current is applied to the anode and the cathode. The current flows to the surface of the metal member via the cracks in the oxide, maintaining the metal member anode in a state of depassivation and loosening the bond between the oxide film and the metal member. The loosened magnetite is then readily cleaned off the metal member. A thermal stressing step may also be used prior to the mechanical stressing.

Abstract: A manufactured metal member, such as a wire, having a magnetite oxide film thereon, is first subjected to stress to produce cracking of the magnetite film approximately to the surface of the metal member. The metal member is then moved through an electrolysis cell bath in which the metal member forms the anode thereof, and vertically positioned steel bars form the cathode. A pulsating DC current is applied to the anode and the cathode. The current flows to the surface of the metal member via the cracks in the oxide, maintaining the metal member anode in a state of depassivation and loosening the bond between the oxide film and the metal member. The loosened magnetite is then readily cleaned off the metal member.