Abstract: A method is provided for handling loads in a warehouse for containers that may be automatically stored and removed from storage by a container stacking crane, between a storage area and a truck or other vehicle parked in a parking space of a loading and unloading area To optimize the throughput performance and safety of handling loads in a warehouse for containers, it is proposed that after the truck drives into the parking space and after the driver of the truck leaves the parking space, the parking space is secured against the presence of persons including the driver, before a release signal is given to the container stacking crane for the automatic loading or unloading process.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention provides compounds for modulating c-Kit kinase activity and methods of treating diseases mediated by c-Kit activity utilizing the compounds and pharmaceutical compositions thereof.

Abstract: The invention relates to novel assays for the in vivo analysis of neurodegenerative diseases and the use of such assays to discover therapies capable of modulating such diseases.

Abstract: The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: A method is provided for handling loads in a warehouse for containers that may be automatically stored and removed from storage by a container stacking crane, between a storage area and a truck or other vehicle parked in a parking space of a loading and unloading area To optimize the throughput performance and safety of handling loads in a warehouse for containers, it is proposed that after the truck drives into the parking space and after the driver of the truck leaves the parking space, the parking space is secured against the presence of persons including the driver, before a release signal is given to the container stacking crane for the automatic loading or unloading process.

Abstract: The invention relates to novel assays for the in vivo analysis of neurodegenerative diseases and the use of such assays to discover therapies capable of modulating such diseases.

Abstract: The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Abstract: The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Abstract: Compounds of formula III: wherein R5a, R3, X, Y, Q, R1a and R1b are as defined in the specification, pharmaceutically acceptable salts thereof, and methods of use thereof.

Abstract: Methods and apparatus, including computer systems, are provided for securitizing a mortality risk. A premium is received by an issuer from a counterparty, and the issuer provides coverage of a mortality risk to the counterparty. An investment is received by the issuer from an investor, and the issuer provides a risk instrument to the investor. The risk instrument provides a contingent return of the investment to the investor, where if a first condition is satisfied then the entire investment is returned, if a second condition is satisfied then none of the investment is returned, and if neither the first nor the second conditions are satisfied then a portion of the investment is returned. The first and second conditions are related to the mortality risk.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Abstract: The invention relates to a method and a device for safely disconnecting electric drives, wherein disturbances of the electric drive which are independent from the driving and lifting speed are recognized in a delay-free manner by retaining the safety function and are used for disconnecting the electric drive. The signals of the sensors (7.1, 7.2, 8.1, 8.2) are detected in a redundant manner and are redundantly compared to preselected threshold values in evaluation devices (2.1, 2.2) such that the electric drive (12) is safely disconnected in a redundant manner without using mechanical position devices if the preselected threshold value of the electric drive (12) is exceeded.

Abstract: The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellu-lar activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention provides compounds for modulating c-Kit kinase activity and methods of treating diseases mediated by c-Kit activity utilizing the compounds and pharmaceutical compositions thereof.

Abstract: The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: This invention provides a system for modeling neurodegenerative and other diseases through somatic gene transfer. In addition, methods of multiple gene transfer, disease analysis and drug testing are provided for.

Abstract: A container for collecting sharps includes an opening adapted to receive sharps in a substantially vertical orientation, and an interior region for storing sharps received through the opening. The container includes a means for reorienting the sharps into an arrangement in which the sharps lie substantially parallel to one another within the interior region of the container. A method for configuring a sharps collection container includes the step of positioning a contoured surface of a guide element beneath an opening of the container to reorient sharps that are deposited through the opening into an arrangement in which the sharps are stored substantially parallel to one another in the container.

Abstract: The invention relates to a method and a device for safely disconnecting electric drives, wherein disturbances of the electric drive which are independent from the driving and lifting speed are recognised in a delay-free manner by retaining the safety function and are used for disconnecting the electric drive. The signals of the sensors (7.1, 7.2, 8.1, 8.2) are detected in a redundant manner and are redundantly compared to preselected threshold values in evaluation devices (2.1, 2.2) such that the electric drive (12) is safely disconnected in a redundant manner without using mechanical position devices if the preselected threshold value of the electric drive (12) is exceeded.

Abstract: This invention provides a system for modeling neurodegenerative and other diseases through somatic gene transfer. In addition, methods of multiple gene transfer, disease analysis and drug testing are provided for.

Abstract: A product dispensing system and a method of queuing usage of products. A plurality of layers of products, each having multiple items in separate packages, each layer having a carrier with the separate packages being secured to and extending from the carrier. The layers are assembled in a stacked orientation behind a front layer with layers behind the front layer being at least partially concealed and inaccessible. Products are used one layer at a time, and when the separate packages from the front layer are removed, the packages of the next-succeeding layer are exposed for use.