Patents by Inventor Ronald Knegtel

Ronald Knegtel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
    Publication number: 20100099686
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: December 14, 2007
    Publication date: April 22, 2010
    Inventors: Jean-Damien Charrier, Ronald Knegtel, David Kay
  • Compositions useful as inhibitors of protein kinases
    Patent number: 7700609
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: April 20, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Juan-Miguel Jimenez, Jeremy Green, Huai Gao, Young-Choon Moon, Guy Brenchley, Ronald Knegtel, Francoise Pierard
  • Pyrazole compounds useful as protein kinase inhibitors
    Patent number: 7691853
    Abstract: This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T—R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2?, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: April 6, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Hayley Binch, Ronald Knegtel, Julian M. C. Golec, Sanjay Patel, Jean-Damien Charrier, David Kay, Robert J. Davies, Pan Li, Marion W. Wannamaker, Cornelia J. Forster, Albert C. Pierce
  • PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
    Publication number: 20090312543
    Abstract: This invention describes novel pyrazole compounds of formula IIIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx, Ry, R2, and R2? are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Application
    Filed: August 21, 2009
    Publication date: December 17, 2009
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Jean-Damien Charrier, Julian C. Golec, Andrew Miller, Ronald Knegtel
  • THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES
    Publication number: 20090306155
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
    Type: Application
    Filed: August 10, 2009
    Publication date: December 10, 2009
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Juan-Miguel Jimenez, Ronald Knegtel, Daniel Robinson, Philip Collier
  • Pyrazole compounds useful as protein kinase inhibitors
    Patent number: 7625913
    Abstract: This invention describes novel pyrazole compounds of formula IIIc: wherein R1 is T—Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx, Ry, R2, and R2? are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: December 1, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Andrew Miller, Ronald Knegtel
  • Dihydrodiazepines useful as inhibitors of protein kinases
    Patent number: 7622463
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: November 24, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Kay, Ronald Knegtel, Jean-Damien Charrier, Heather Twin
  • Crystal structure of aurora-2 protein and binding pockets thereof
    Publication number: 20090287422
    Abstract: The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
    Type: Application
    Filed: February 13, 2008
    Publication date: November 19, 2009
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Graham Cheetham, Ronald Knegtel, Lovorka Swenson, Joyce T. Coll, Suzanne Renwick, Peter Weber
  • Thiophene-carboxamides useful as inhibitors of protein kinases
    Publication number: 20090286840
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: April 12, 2007
    Publication date: November 19, 2009
    Inventors: Guy Brenchley, Steven Durrant, Jean-Damien Charrier, Ronald Knegtel, Sharn Ramaya, Shazia Sadiq
  • CASPASE INHIBITORS AND USES THEREOF
    Publication number: 20090281128
    Abstract: The present invention relates to compounds of formula I: useful as inhibitors of caspases. The present invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for preparing the compounds, and methods of using the compounds and compositions in the treatment of various diseases, conditions, or disorders.
    Type: Application
    Filed: May 12, 2009
    Publication date: November 12, 2009
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Ronald Knegtel, Michael Mortimore, John Studley, David Millan
  • COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
    Publication number: 20090281082
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 12, 2009
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Ronald Knegtel, Jean-Damien Charrier, Steven Durrant, Guy Brenchley, Michael Mortimore
  • Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
    Patent number: 7589214
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: September 15, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Juan-Miguel Jimenez, Ronald Knegtel, Daniel Robinson, Philip Collier
  • Caspase inhibitors and uses thereof
    Patent number: 7553852
    Abstract: The present invention relates to compounds of formula I: useful as inhibitors of caspases. The present invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for preparing the compounds, and methods of using the compounds and compositions in the treatment of various diseases, conditions, or disorders.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: June 30, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Ronald Knegtel, Michael Mortimore, John Studley, David Millan
  • KINASE INHIBITORS
    Publication number: 20090124602
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: August 7, 2008
    Publication date: May 14, 2009
    Inventors: FRANCOIS MALTAIS, GUY BEMIS, TIANSHENG WANG, JUAN-MIGUEL JIMENEZ, RONALD KNEGTEL, CHRIS DAVIS, DAMIEN FRAYSSE
  • Pyrazole compounds useful as protein kinase inhibitors
    Patent number: 7531536
    Abstract: This invention describes novel pyrazole compounds of formula IIIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx, Ry, R2; and R2? are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: May 12, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Andrew Miller, Ronald Knegtel
  • Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
    Patent number: 7528138
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 5, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Ronald Knegtel, Juan-Miguel Jimenez, Jean-Damien Charrier, Dean Stamos, Pan Li, Jon Come, Alex Aronov
  • CASPASE INHIBITORS AND USES THEREOF
    Publication number: 20090093416
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.
    Type: Application
    Filed: June 17, 2008
    Publication date: April 9, 2009
    Inventors: Guy Brenchley, Jean-Damien Charrier, Steven Durrant, Ronald Knegtel, Michael Mortimore, John R. Studley
  • Tetrahydropteridines useful as inhibitors of protein kinases
    Publication number: 20090062292
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: April 12, 2007
    Publication date: March 5, 2009
    Inventors: Jean-Damien Charrier, David Kay, Ronald Knegtel
  • Dihydrodiazepines useful as inhibitors of protein kinases
    Publication number: 20080167289
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: February 13, 2007
    Publication date: July 10, 2008
    Inventors: David Kay, Ronald Knegtel, Jean-Damien Charrier, Heather Twin
  • Pyrazole compounds useful as protein kinase inhibitors
    Patent number: 7390815
    Abstract: This invention describes novel pyrazole compounds of formula II: wherein Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, and R2, R2?, Rx, and Ry are as described in the specification. Ring C has an ortho substituent and is optionally substituted in the non-ortho positions. R2 and R2? are optionally taken together with their intervening atoms to form a fused ring system, such as an indazole ring; and Rx and Ry are optionally taken together with their intervening atoms to form a fused ring system, such as a quinazoline ring. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3, for treating diseases such as diabetes and Alzheimer's disease.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: June 24, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Robert Davies, David Bebbington, Ronald Knegtel, Marion Wannamaker, Pan Li, Cornelia Forster, Albert Pierce