Patents by Inventor Ronald Kramer

Ronald Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12612370
    Abstract: Methods of enhancing muscle growth in a human are disclosed. The method comprises administering to the human a pharmaceutically effective amount of a composition or supplement formulation comprising at least one constituent selected from the group consisting of a nitrate, a nitrite, and both. In some aspects, the composition further comprises at least one constituent amino acid.
    Type: Grant
    Filed: January 17, 2025
    Date of Patent: April 28, 2026
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12594249
    Abstract: Disclosed is a composition including ammonia and curcumin or curcuminoid, such as an ammonium phenoxide of curcumin. Also disclosed is a method for forming an ammonium phenoxide of curcumin or curcuminoid including dissolving the curcumin or curcuminoid in an ammonia solution. Further disclosed is a method of treating a curcumin-improvable condition including administering an ammonium phenoxide of curcumin or curcuminoid to a subject.
    Type: Grant
    Filed: June 3, 2024
    Date of Patent: April 7, 2026
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12577210
    Abstract: Solid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Grant
    Filed: January 17, 2025
    Date of Patent: March 17, 2026
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12577209
    Abstract: Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Grant
    Filed: January 17, 2025
    Date of Patent: March 17, 2026
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12540119
    Abstract: Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Grant
    Filed: January 17, 2025
    Date of Patent: February 3, 2026
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Publication number: 20260027149
    Abstract: A novel method of producing an NO+H2 solution is disclosed as well as liquid compositions comprising stable and high concentrations of NO and H2.
    Type: Application
    Filed: July 28, 2025
    Publication date: January 29, 2026
    Inventors: Ronald KRAMER, Alexandros NIKOLAIDIS
  • Patent number: 12533327
    Abstract: Salts of hexylamine, for example, hexylamine succinate and tri-hexylamine citrate and their method of production are described. The disclosure also relates to compositions comprising hexylamine, for example, for reducing appetite in a human subject, treating obesity in a human subject, preventing obesity in a human subject, preventing weight gain in a human subject, increasing fat loss in a human subject, treating an overweight human subject, increasing athletic performance in a human subject, increasing endurance in a human subject, increasing muscle strength in a human subject, improving cognitive function in a human subject, treating ADHD in a human subject, increasing sweating in a human subject, reducing reaction time of a human subject, increasing psychomotor vigilance of a human subject, enhancing memory in a human subject, increasing central nervous system activity in a human subject, and enhancing alertness, attention, concentration, and/or memory in a human subject.
    Type: Grant
    Filed: September 27, 2023
    Date of Patent: January 27, 2026
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12522568
    Abstract: Solid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Grant
    Filed: January 17, 2025
    Date of Patent: January 13, 2026
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12491168
    Abstract: Salts of hexylamine, for example, hexylamine succinate and tri-hexylamine citrate and their method of production are described. The disclosure also relates to compositions comprising hexyalmine, for example, for reducing appetite in a human subject, treating obesity in a human subject, preventing obesity in a human subject, preventing weight gain in a human subject, increasing fat loss in a human subject, treating an overweight human subject, increasing athletic performance in a human subject, increasing endurance in a human subject, increasing muscle strength in a human subject, improving cognitive function in a human subject, treating ADHD in a human subject, increasing sweating in a human subject, reducing reaction time of a human subject, increasing psychomotor vigilance of a human subject, enhancing memory in a human subject, increasing central nervous system activity in a human subject, and enhancing alertness, attention, concentration, and/or memory in a human subject.
    Type: Grant
    Filed: January 3, 2023
    Date of Patent: December 9, 2025
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12473261
    Abstract: Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Grant
    Filed: January 17, 2025
    Date of Patent: November 18, 2025
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12448357
    Abstract: Methods of improving pharmacodynamic properties of an amino acid in a human subject is disclosed. The method comprises administering to the human subject the amino acid in the form of a nitrate salt, wherein the nitrate salt form of the amino acid is faster acting compared to other forms of the amino acid.
    Type: Grant
    Filed: June 17, 2024
    Date of Patent: October 21, 2025
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Patent number: 12441615
    Abstract: The disclosure relates to methods of producing nitric oxide (NO) gas that is administrable without specialized equipment and does not provide nitrogen dioxide (NO2) gas. The methods comprise combining a nitrate and/or nitrite anion and an elemental metal in an acidic solution in a vessel capable of housing liquid and gas constituents, wherein NO gas is produced by the reaction of the nitrate and/or nitrite anion and the elemental metal in the acidic solution. The method further comprises administering the NO gas produced to the subject via inhalation. Also described are compositions and kits for improved delivery of NO gas.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: October 14, 2025
    Assignee: ThermoLife International, LLC
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Publication number: 20250255926
    Abstract: A composition for human ingestion that provides improved bioaccesibility, solubility, and/or bioavailability of the extract of ginger is disclosed. The composition comprises an extract of ginger and a source of lithium. A method of improving bioaccesibility, solubility, and/or bioavailability of an extract of ginger is further disclosed, and the method comprises: providing the extract of ginger; and mixing a source of lithium with the ginger extract, thereby producing a water-soluble form of ginger extract. Also disclosed is a method of treating a gingerol-improvable condition that comprises administering to a subject 0.01-30,000 ml of a composition comprising an extract of ginger and a source of lithium. Further disclosed is a method of improving athletic performance in a subject that comprises administering to the subject 0.01-30,000 ml of a composition comprising an extract of ginger and a source of lithium prior to the subject exercising.
    Type: Application
    Filed: February 7, 2025
    Publication date: August 14, 2025
    Inventors: Ronald KRAMER, Alexandros NIKOLAIDIS
  • Publication number: 20250257522
    Abstract: A fabric having ultraviolet radiation protection and antimicrobial protection has a quantity of ZnO incorporated into the fabric and a quantity of a dye incorporated into the fabric. A synthetic fabric having ultraviolet radiation protection and antimicrobial protection has a quantity of ZnO incorporated into the synthetic fabric and a quantity of a dye incorporated into the synthetic fabric.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 14, 2025
    Inventors: Robert B. Kramer, Ronald Kramer, Jason Rosenberg, Peter Hauser
  • Publication number: 20250195564
    Abstract: The disclosure is directed to a method of replenishing a subject's iron, ferritin, and/or hemoglobin level. The method includes orally administering elemental metal iron to the subject; and orally administering a source of nitrate anion to the subject.
    Type: Application
    Filed: February 28, 2025
    Publication date: June 19, 2025
    Inventors: Ronald KRAMER, Alexandros NIKOLAIDIS
  • Publication number: 20250171406
    Abstract: Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Application
    Filed: January 17, 2025
    Publication date: May 29, 2025
    Inventors: Ronald KRAMER, Alexandros NIKOLAIDIS
  • Publication number: 20250170173
    Abstract: The disclosure is directed to compositions and methods of increasing oxygen saturation (SpO2) in subjects in need thereof as well as alleviating, treating or curing symptoms and conditions associated with lower SpO2 levels (below 95%). The compositions are preferably solid and comprise a nitrate anion source, an elemental metal (uncharged), and optionally an acid. The compositions are preferably administered orally.
    Type: Application
    Filed: December 3, 2024
    Publication date: May 29, 2025
    Inventors: Ronald Kramer, Alexandros Nikolaidis
  • Publication number: 20250163001
    Abstract: Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Inventors: Ronald KRAMER, Alexandros NIKOLAIDIS
  • Publication number: 20250162997
    Abstract: Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Inventors: Ronald KRAMER, Alexandros NIKOLAIDIS
  • Publication number: 20250162996
    Abstract: Solid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3?).
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Inventors: Ronald KRAMER, Alexandros NIKOLAIDIS