Abstract: A robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The method includes measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.

Abstract: A process of preparing nanoparticulate contrast agents comprising the steps of:preparing a premix of the contrast agent and a surface modifier; andsubjecting the premix to mechanical means to reduce the particle size of the contrast agent, the mechanical means producing shear, impact, cavitation and attrition.

Abstract: A process of preparing nanoparticulate drug substances comprising the steps of: preparing a premix of the drug substance and a surface modifier, and subjecting the premix to mechanical means to reduce the particle size of the drug substance, the mechanical means producing shear, impact, cavitation and attrition.

Abstract: An electrostatic developer consisting essentially of (A) a nonpolar liquid having a Kauri-butanol value of less than 30, present in a major amount; (B) thermoplastic resin particles, less than 30 .mu.m average particle size, a nonpolar liquid soluble ionic or zwitterionic charge director compound (C), and (D) a metal salt of a .beta.-diketone as described. The process of preparation of the liquid electrostatic developer is also described. The liquid developers of the invention are useful in copying, color proofing, including digital color proofing, lithographic printing plates and resists.

Abstract: Electrostatic liquid developer consisting essentially of(A) nonpolar liquid, Kauri-butanol value less than 30,(B) particles of thermoplastic resin having free carboxyl groups (<30.mu.m ave particle size),(C) nonpolar liquid soluble oil-soluble petroleum sulfonate or anionic glyceride charge director, and(D) at least one organometallic compound as defined present in 0.01 to 0.15 part by weight metal based on the total weight of liquid developer. The process of preparation of the liquid developer is also disclosed. The developers demonstrate reduced mottle in a fused image. The developers are used in copying, color proofing, preparation of lithographic printing plates and resists.