Abstract: The present invention is directed to compressed tablets for oral administration, which comprise an intragranular component comprising the potassium salt of raltegravir, an inert superdisintegrant, and a binder; and an extragranular component comprising a superdisintegrant and a lubricant.

Abstract: A hair retaining device is provided. The hair retaining device includes a tubular base member which defines an interior volume. When the hair retaining device is worn the tubular base member surrounds a length of a wearer's hair. The tubular base member has a first terminal end and a second terminal end. A flexible opening on the first terminal end can be widened to allow a wearer to pass their hair therethrough. A strap is disposed outwardly from the second terminal end of the tubular member with a clip disposed on a distal end of the strap. The clip can be utilized to secure the hair retaining device to an article of the wearer's clothes. The hair retaining device can contain a wearer's hair while still allowing the wearer to move around in an unrestricted fashion.

Abstract: The present invention provides a process for preparing enterically-coated lyospheres comprising a therapeutic agent comprising: a.) providing lyospheres comprising the therapeutic agent; b.) coating said lyospheres with an enteric polymer coating composition; and c.) isolating said enterically-coated lyospheres. In other embodiments, the invention provides dosage forms comprising a lyosphere comprising an effective amount of a therapeutic agent and an enteric polymer coating. In some embodiments, the therapeutic agent in the process or dosage form is a polypeptide, a protein, a peptide, a lipopeptide, a glycoprotein, a fusion protein, a protein conjugate, a cytokine, an enzyme, an antibody, an oligonucleotide, a vaccine vector, small molecule, a live virus, an inactivated virus, a virus-like particle, a viral protein subunit, an adjuvant, microbiome, a prebiotic, a probiotic, or an ectobiotic.

Abstract: The present invention provides a process for preparing enterically-coated lyospheres comprising a therapeutic agent comprising: a.) providing lyospheres comprising the therapeutic agent; b.) coating said lyospheres with an enteric polymer coating composition; and c.) isolating said enterically-coated lyospheres. In other embodiments, the invention provides dosage forms comprising a lyosphere comprising an effective amount of a therapeutic agent and an enteric polymer coating. In some embodiments, the therapeutic agent in the process or dosage form is a polypeptide, a protein, a peptide, a lipopeptide, a glycoprotein, a fusion protein, a protein conjugate, a cytokine, an enzyme, an antibody, an oligonucleotide, a vaccine vector, small molecule, a live virus, an inactivated virus, a virus-like particle, a viral protein subunit, an adjuvant, microbiome, a prebiotic, a probiotic, or an ectobiotic.

Abstract: The present invention relates to pharmaceutical compositions of the poorly soluble drugs, and pharmaceutically acceptable salts thereof, in a controlled-release gastric retained oral dosage form. Such compositions are formulated so as to deliver the majority of the incorporated drug into the stomach and upper gastrointestinal tract, with restricted drug delivery in the lower gastrointestinal tract. The dosage forms have multiple layers including an active layer with a first swellable polymer with raltegravir incorporated therein and a non-active layer with a second swellable polymer having a similar molecular weight or a higher molecular weight as the swellable polymer in the active layer.

Abstract: The present invention relates to Amido-Substituted Pyrimidinone Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyrimidinone Derivative, and methods of using the Amido-Substituted Pyrimidinone Derivatives for treating or preventing HIV infection in a subject.

Abstract: A strap having increased column stiffness includes a leading edge and a trailing edge forming a length of the strap, a first outer edge and second outer edge defining a width of the strap, and a first side and a second side defining a thickness of the strap. A crush region is formed in the first or second side, between and generally parallel to the first and second outer edges. The crush region is defined by a thickness that is less than the thickness of the strap adjacent to the crush region. The crush region forms a line along which a bend may be formed in the strap. The bend increases the column stiffness of the strap at least about 67 percent over that of a comparable flat strap. The bend defines an acute angle and an obtuse angle in the strap as viewed in cross-section.

Abstract: A bullet feeding device has an expandable collet insertable into a die body. The die body receives bullets from a source and directs the bullets to the expandable collet. The expandable collet restricts the passage of the bullet through the die body until the mouth of a cartridge case is inserted into the die body opposite the bullet. The mouth of the cartridge case causes the expandable collet to expand and allow the single bullet to pass through the expandable collet and be placed in the mouth of the cartridge case. As the completed cartridge is drawn from the die body, the expandable collet and prevents the passage of additional bullets until a new cartridge case is inserted. The bullet feeding device may accept bullets of different lengths and shapes. The collet is interchangeable with expandable collets of other sizes to be compatible with bullets of different sizes.

Abstract: A bullet feeding device has an expandable collet insertable into a die body. The die body receives bullets from a source and directs the bullets to the expandable collet. The expandable collet restricts the passage of the bullet through the die body until the mouth of a cartridge case is inserted into the die body opposite the bullet. The mouth of the cartridge case causes the expandable collet to expand and allow the single bullet to pass through the expandable collet and be placed in the mouth of the cartridge case. As the completed cartridge is drawn from the die body, the expandable collet and prevents the passage of additional bullets until a new cartridge case is inserted. The bullet feeding device may accept bullets of different lengths and shapes. The collet is interchangeable with expandable collets of other sizes to be compatible with bullets of different sizes.

Abstract: A bullet feeding device having an expandable collet insertable into a die body. The die body is capable of receiving bullets from a source and directing the bullets to the expandable collet. The expandable collet restricts the passage of the bullet through the die body until the mouth of a cartridge case is inserted into the die body opposite the bullet. The mouth of the cartridge case causes the expandable collet to expand and allow the single bullet to pass through the expandable collet and be placed in the mouth of the cartridge case. As the completed cartridge is drawn from the die body, the expandable collet contracts above the tip of the bullet and prevents the passage of additional bullets until a new cartridge case is inserted. The expandable collet is capable of accepting bullets of different lengths and shapes. In addition, the expandable collet is easily interchangeable with expandable collets of other sizes to be compatible with bullets of different diameters.

Abstract: A strap having increased column stiffness includes a leading edge and a trailing edge forming a length of the strap, a first outer edge and second outer edge defining a width of the strap, and a first side and a second side defining a thickness of the strap. A crush region is formed in the first or second side, between and generally parallel to the first and second outer edges. The crush region is defined by a thickness that is less than the thickness of the strap adjacent to the crush region. The crush region forms a line along which a bend may be formed in the strap. The bend increases the column stiffness of the strap at least about 67 percent over that of a comparable flat strap. The bend defines an acute angle and an obtuse angle in the strap as viewed in cross-section.

Abstract: A bullet feeding device having an expandable collet insertable into a die body. The die body is capable of receiving bullets from a source and directing the bullets to the expandable collet. The expandable collet restricts the passage of the bullet through the die body until the mouth of a cartridge case is inserted into the die body opposite the bullet. The mouth of the cartridge case causes the expandable collet to expand and allow the single bullet to pass through the expandable collet and be placed in the mouth of the cartridge case. As the completed cartridge is drawn from the die body, the expandable collet contracts above the tip of the bullet and prevents the passage of additional bullets until a new cartridge case is inserted. The expandable collet is capable of accepting bullets of different lengths and shapes. In addition, the expandable collet is easily interchangeable with expandable collets of other sizes to be compatible with bullets of different diameters.

Abstract: The present invention provides a solution to the dual problems of mobility and portability associated with using a portable telephone in combination with a portable computer. A portable computer (164) has an interface (172, 192, 204) that facilitates a direct connection to a portable telephone (166). The interface (172, 192, 204) electrically connects the portable telephone (166) to the portable computer (164) thus eliminating the need for a cable or tethered connection between the portable computer (164) and a portable telephone (166). In one embodiment of the invention, the portable telephone (166) is constructed to fit within a cavity (210) in the portable computer (164). When fully inserted into the computer (164), the portable telephone (166) is physically connected to the portable computer (164) by a latching mechanism and communicates with the portable computer by means of a computer/portable telephone interface (172, 192, 204 that electrically connects the portable telephone to the portable computer).

Abstract: The present invention relates to methods for detecting microbes in a sample comprising filtering the sample through a fluid-permeable surface, contacting the surface with a viability stain, scanning the surface for viability stain to form a first scan, contacting the surface with a nucleic acid stain, scanning the surface for nucleic acid stain to form a second scan, and comparing said first scan and said second scan.

Abstract: The present invention provides a solution to the dual problems of mobility and portability associated with using a portable telephone in combination with a portable computer. An interface module (40) has a first interface (44) for coupling to an interface (34) on a portable telephone (16) and a second interface (58) for coupling to an interface (68) on a portable computer (62). The interface module (40) facilitates a direct connection between a coupled interface module and portable telephone (60) to a portable computer (62). The interface module (40) electrically couples the portable telephone (16) to the portable computer (62) thus eliminating the need for a cable or tethered connection between the portable computer (62) and portable telephone (16).

Abstract: A modified-release vasopeptidase inhibitor formulation is provided which is capable of releasing vasopeptidase inhibitor, preferably omapatrilat or gemopatrilat, in a manner to provide therapeutically effective NEP inhibitory activity and therapeutically effective ACE inhibitory activity, in a balanced manner, for a predetermined duration to lower blood pressure and/or treat heart failure. In a preferred formulation, the NEP inhibitory activity and ACE inhibitory activity have balanced release characteristics.

Abstract: The present invention provides a solution to the dual problems of mobility and portability associated with using a portable telephone in combination with a portable computer in a telecommunications environment. The invention comprises a coupled portable telephone(16)/interface module (40) that may be directly coupled to a portable computer (62). The interface module (40) portion of the invention includes a first interface (44) for coupling to an interface (34) on a portable telephone (16) and a second interface (58) for coupling to an interface (68) on a portable computer (62). The interface module (40) facilitates a direct connection between a coupled portable telephone (16)/interface module (40) and a portable computer (62).

Abstract: A kit for making a decorative article includes a support having a grid array on the surface thereon, a plurality of colored tiles, and a source of information for communicating or illustrating how each of the tiles correspond to the grid array. Embodiments include a stiff support comprising any one or more of cardboard, heavy cardstock, foam board, wood, etc. and having a length and a width of each of from about 6 inches to about 60 inches and a thickness of about ⅛ inch to about ½ inch where the grid array is printed on a surface thereof and comprises a plurality of regularly shaped segments and each segment contains a symbol or number therein.

Abstract: A hand-held tool for loading a primer into a primer socket of an ammunition cartridge case includes an elongate body with a holder for holding a cartridge case with its primer socket in a target position in a priming station. An elongate track on the tool longitudinally guides a rectilinear primer holding strip through the priming station. A reciprocating advancing member moves in advancing and retracting directions, and in its advancing direction engages the primer strip to sequentially align successive primers in the strip with the target position. A detent holds the primer strip against retraction when the advancing member moves in its retracting direction. A plunger is mounted for shifting longitudinally of the body into and away from the priming station to push a primer out of the primer strip into the primer socket of the cartridge. An elongate operator handle is connected to the body for movement relative thereto.

Abstract: A measurement of thickness of a metal oxide layer on a solder ball connection during semiconductor fabrication is demonstrated by an in-situ capacitance measurement of the oxide layer. A linear relationship is shown between the reactance of the metal oxide and its thickness. This linearity is derived empirically, and correlated to Auger Spectroscopy test results for accuracy. The linear relationship demonstrated with these measurements exhibits a linear correlation coefficient, R2, greater than or equal to 0.974. This close, linear relationship allows for accurate testing of the oxide thickness using standard electrical parameter measurements during wafer fabrication.