Patents by Inventor Ronald Lauener

Ronald Lauener has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZYLATED PDE4 INHIBITORS
    Publication number: 20070208181
    Abstract: The present invention is directed to a method for reducing the emetogenic effects of PDE inhibitors, and more particularly is directed to compounds having PDE4 inhibition activity with little or no emetogenic side-effects, and chemical methods including benzylation for preparing such compounds. A benzyl group may be attached to either a carbon or nitrogen atom of a PDE4 inhibitor. Suitable benzylation chemistry is to extract a hydrogen from a PDE4 inhibitor, preferably with a base, and then react the resulting nucleophilic PDE4 inhibitor with a benzylating agent, e.g., benzyl bromide or a derivative thereof.
    Type: Application
    Filed: March 8, 2007
    Publication date: September 6, 2007
    Applicant: INFLAZYME PHARMACEUTICALS LTD.
    Inventors: Ronald Lauener, David Burgoyne, Patrick Rebstein, Lloyd Mackenzie, Yuanlin Zhou, Yaping Shen