Abstract: Provided herein are compositions comprising CXCR1/CXCR2 inhibitors as well as methods of using the CXCR1/CXCR2 inhibitors disclosed herein. In embodiments, provided are methods of treating myelofibrosis, methods of decreasing bone marrow fibrosis, methods of reducing the interaction of IL-8 to CXCR1 and/or CXCR2, and methods of reducing the activity or and/or signaling through CXCR1 and/or CXCR by administering to a subject in need thereof an effective amount of a CXCR1/CXCR2 inhibitor disclosed herein.

Abstract: A device for coupling a propulsor to a marine vessel. The device includes a mounting bracket configured for attachment to the marine vessel. A support frame has a carriage and is configured for the propulsor to be coupled thereto, where the carriage is configured to slidably engage with the mounting bracket into a fixed position. A member is manually engageable to prevent the carriage from sliding out of the fixed position. The propulsor is coupled to the marine vessel by sliding the carriage into the fixed position and engaging the member, where the propulsor is operable to propel the marine vessel in water when the carriage is in the fixed position, and where the propulsor is configured for decoupling from the marine vessel by disengaging the member and sliding the carriage out of engagement with the mounting bracket.

Abstract: A versatile flying lead (VHL) termination head system comprises an underwater vehicle interface, an interface plate, a termination frame, and an adjuster, disposed proximate the termination frame's connection end, which is configured to provide a configurable declination angle which sets a hang-off angle of a device connected to the interface plate with respect to the underwater vehicle interface. A subsea termination head may be manufactured and assembled by obtaining a predetermined set of standardized structural building blocks that fit together to form a complete termination frame which is as described herein, using the predetermined set of standardized structural building blocks to construct a subsea termination head from the predetermined set of standardized structural building blocks substantially in parallel and connecting the underwater vehicle interface to the frame at a predetermined angle using the adjuster.

Abstract: A versatile flying lead (VHL) termination head system comprises an underwater vehicle interface, an interface plate, a termination frame, and an adjuster, disposed proximate the termination frame's connection end, which is configured to provide a configurable declination angle which sets a hang-off angle of a device connected to the interface plate with respect to the underwater vehicle interface. A subsea termination head may be manufactured and assembled by obtaining a predetermined set of standardized structural building blocks that fit together to form a complete termination frame which is as described herein, using the predetermined set of standardized structural building blocks to construct a subsea termination head from the predetermined set of standardized structural building blocks substantially in parallel and connecting the underwater vehicle interface to the frame at a predetermined angle using the adjuster.

Abstract: A versatile flying lead (VHL) termination head system comprises an underwater vehicle interface, an interface plate, a termination frame, and an adjuster, disposed proximate the termination frame's connection end, which is configured to provide a configurable declination angle which sets a hang-off angle of a device connected to the interface plate with respect to the underwater vehicle interface. A subsea termination head may be manufactured and assembled by obtaining a predetermined set of standardized structural building blocks that fit together to form a complete termination frame which is as described herein, using the predetermined set of standardized structural building blocks to construct a subsea termination head from the predetermined set of standardized structural building blocks substantially in parallel and connecting the underwater vehicle interface to the frame at a predetermined angle using the adjuster.

Abstract: A diagnostic system may utilize telemetry from a monitored system to infer information about the operation of various components systems within the monitored system. In embodiments, inferences may be drawn from a comparison of various component systems using a system of implication and exoneration. Exoneration is utilized to isolate faulty components from functioning components by comparing information between the systems, which may run in parallel. A dynamic grouping algorithm may eventually isolate faulty components and suggest the root cause as well as multiple distinct faults.