Patents by Inventor Ronald M. Cresswell

Ronald M. Cresswell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing 3-morpholino-2-cyanoacrylamide
    Patent number: 4146713
    Abstract: A compound ##STR1## where R' is hydrogen or lower alkyl, the compound being usable as an intermediate in the preparation of 4-hydroxypyrazolo [3,4-d]pyrimidine (Allopurinol) and its useful relatives.A method of preparing ##STR2## which comprises reacting R'C(OR).sub.3, morpholine and cyanoacetamide where R' is hydrogen or lower alkyl and R' is lower alkyl.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: March 27, 1979
    Assignee: Burroughs Wellcome Co.
    Inventors: Ronald M. Cresswell, John W. Mentha, Russell Seaman
  • Method and preparation for increasing bioavailability of digoxin
    Patent number: 4088750
    Abstract: Method and preparation for increasing the bioavailability of digoxin to treat cardiac insufficiency in a human, said method comprising the administration of a preparation comprising a capsule adapted to release a solution of digoxin in an amount sufficient to treat cardiac insufficiency.
    Type: Grant
    Filed: January 28, 1976
    Date of Patent: May 9, 1978
    Assignee: Burroughs Wellcome Co.
    Inventors: Ronald M. Cresswell, Elvin A. Holstius
  • 5-Benzyl pyrimidines intermediates therefore, and method
    Patent number: 4052553
    Abstract: Compounds comprising selected N-substituted .beta.-amino-.alpha.-benzyl-acrylonitriles and methods of preparing said compounds substantially free from the corresponding benzalacrylonitrile.The compounds are useful as intermediates in the preparation of antibacterial and antimalarial agents.
    Type: Grant
    Filed: June 15, 1972
    Date of Patent: October 4, 1977
    Assignee: Burroughs Wellcome Co.
    Inventors: Ronald M. Cresswell, John W. Mentha, Russell L. Seaman
  • Process for preparing .beta.-amino-.alpha.-benzylacrylonitriles
    Patent number: 3998814
    Abstract: Compounds comprising selected N-substituted .beta.-amino-.alpha.-benzyl-acrylonitriles and methods of preparing said compounds substantially free from the corresponding benzalacrylonitrile.The compounds are useful as intermediates in the preparation of antibacterial and antimalarial agents.
    Type: Grant
    Filed: May 2, 1974
    Date of Patent: December 21, 1976
    Assignee: Burroughs Wellcome Co.
    Inventors: Ronald M. Cresswell, John W. Mentha, Russell L. Seaman
  • Preparation of .beta.-Amino-.alpha.-benzylacrylonitriles
    Patent number: 3991050
    Abstract: Compounds and methods of making compounds of the formula ##SPC1##Where X is a diloweralkylsulphone or diloweralkyl sulphoxide group and R.sup.1 -R.sup.4 is hydrogen, loweralkyl, loweralkoxyl, halogen, benzyloxy or methylenedioxy provided that one of R.sup.1 -R.sup.4 is a substituent other than hydrogen, and where R.sup.7 and R.sup.8 are hydrogen atoms or together represent an additional bond between the carbon and oxygen atoms. The compounds are useful as intermediates in the method of preparing other valuable intermediates which are useful in preparing antibacterial agents.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: November 9, 1976
    Assignee: Burroughs Wellcome Co.
    Inventors: Ronald M. Cresswell, John W. Mentha
  • Preparation of .beta.-anilino-.alpha.-benzylacrylonitriles
    Patent number: 3950378
    Abstract: Compounds comprising selected N-substituted .beta.-amino-.alpha.-benzyl-acrylonitriles and methods of preparing said compounds substantially free from the corresponding bensalacrylonitrile.The compounds are useful as intermediates in the preparation of antibacterial and antimalerial agents.
    Type: Grant
    Filed: May 1, 1974
    Date of Patent: April 13, 1976
    Assignee: Burroughs Wellcome Co.
    Inventors: Ronald M. Cresswell, John W. Mentha, Russell L. Seaman
  • Intermediates for the preparation of pyrimidine compounds
    Patent number: 3939181
    Abstract: There is disclosed a method of making compounds represented by the formula ##SPC1##And which are useful as antimalarial agents. The method includes reacting a keto nitrile with a polyhydroxy compound and then reacting the product with guanidine base. In the above X is a halogen atom or a nitro group, Y is a halogen atom or hydrogen and R is hydrogen or alkyl containing 1 to 10 and preferably is lower alkyl containing 1 to 4 carbon atoms.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: February 17, 1976
    Assignee: Burroughs Wellcome Co.
    Inventors: John W. Mentha, Janice V. Shaffner, Ronald M. Cresswell