Patents by Inventor Ronald Mark Payne

Ronald Mark Payne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METABOLIC BIOMARKERS FOR ASSESSING HEART FAILURE IN A SINGLE VENTRICLE PEDIATRIC SUBJECT
    Publication number: 20240142469
    Abstract: Methods to assess a pediatric subject having a single ventricle heart include identifying a difference between concentration levels of metabolic biomarkers and reference concentration levels and then assessing the pediatric subject based on the identified differences.
    Type: Application
    Filed: February 17, 2022
    Publication date: May 2, 2024
    Inventors: Ronald Mark Payne, Thomas Michael O'Connell
  • MATERIALS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA
    Publication number: 20230242600
    Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.
    Type: Application
    Filed: August 31, 2022
    Publication date: August 3, 2023
    Inventor: Ronald Mark Payne
  • Materials and methods for treating Friedreich's Ataxia
    Patent number: 11459363
    Abstract: A Transactivator of Transcription-frataxin (TAT-FXN) fusion polypeptide useful in treating subjects diagnosed with Friedreich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: October 4, 2022
    Assignee: The Trustees of Indiana University
    Inventor: Ronald Mark Payne
  • MATERIALS AND METHODS FOR TREATING FRIEDRICH'S ATAXIA
    Publication number: 20210047378
    Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.
    Type: Application
    Filed: July 29, 2020
    Publication date: February 18, 2021
    Applicant: The Trustees of Indiana University
    Inventor: Ronald Mark Payne
  • Inducible cell-based model for the study of Friedreich's Ataxia
    Patent number: 9316634
    Abstract: Isolated transduced cells exhibiting FRDA characteristics in an inducible fashion are disclosed. Isolated transduced cells comprise an expression vector having a nucleic acid sequence encoding an shRNA for frataxin protein knockdown and a heterologous expression control sequence. Additionally, methods of screening for a candidate therapeutic agent for treating Friedreich's Ataxia using isolated transduced cells are disclosed. Further, a recombinant nucleic acid construct for frataxin knockdown is disclosed that comprises a nucleic acid encoding an shRNA operably linked to a heterologous expression control sequence and expressing an shRNA molecule in a dose-responsive fashion.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: April 19, 2016
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Ronald Mark Payne, Clifford M. Babbey
  • INDUCIBLE CELL-BASED MODEL FOR THE STUDY OF FRIEDREICH'S ATAXIA
    Publication number: 20140335516
    Abstract: Isolated transduced cells exhibiting FRDA characteristics in an inducible fashion are disclosed. Isolated transduced cells comprise an expression vector having a nucleic acid sequence encoding an shRNA for frataxin protein knockdown and a heterologous expression control sequence. Additionally, methods of screening for a candidate therapeutic agent for treating Friedreich's Ataxia using isolated transduced cells are disclosed. Further, a recombinant nucleic acid construct for frataxin knockdown is disclosed that comprises a nucleic acid encoding an shRNA operably linked to a heterologous expression control sequence and expressing an shRNA molecule in a dose-responsive fashion.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 13, 2014
    Inventors: Ronald Mark Payne, Clifford M. Babbey