Patents by Inventor Ronald MELKI

Ronald MELKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA APTAMERS SPECIFIC FOR A-SYNUCLEIN PROTEIN FIBER CONFORMERS
    Publication number: 20240240191
    Abstract: The present invention relates to an aptamer characterized in that it has the ability to distinguish conformers of F-type ?-Syn fibres of the ?-Syn (?-Syn) protein from conformers of R-type ?-Syn fibres, and in that it comprises a sequence specific for modified ribonucleic acid (RNA) having at least 85% identity with a sequence chosen from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6 and SEQ ID NO: 7, preferably chosen from SEQ ID NO: 1 and SEQ ID NO: 2. The present invention also relates to a composition or a kit comprising at least one of these aptamers, and also to the uses thereof in vitro. The present invention also relates to a method for diagnosing synucleinopathies, as well as to a method for stratification, monitoring, prognosis and evaluation of the efficacy of a synucleinopathy treatment, comprising the use of at least one aptamer and/or a composition and/or a kit mentioned above.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 18, 2024
    Inventors: Alix BOUVIER-MULLER, Frederic DUCONGE, Luc BOUSSET, Ronald MELKI
  • Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
    Patent number: 10906900
    Abstract: The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: February 2, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'ORLEANS, UNIVERSITE DE TOURS, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Sylvain Routier, Franck Suzenet, Sylvie Chalon, Frederic Buron, Johnny Vercouillie, Ronald Melki, Liliana Boiaryna, Denis Guilloteau, Laura Pieri
  • COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES
    Publication number: 20190211011
    Abstract: The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases
    Type: Application
    Filed: September 26, 2017
    Publication date: July 11, 2019
    Inventors: Sylvain ROUTIER, Franck SUZENET, Sylvie CHALON, Frederic BURON, Johnny VERCOUILLIE, Ronald MELKI, Liliana BOIARYNA, Denis GUILLOTEAU, Laura Ronald PIERI