Patents by Inventor Ronald Michalak

Ronald Michalak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
    Patent number: 7728157
    Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: June 1, 2010
    Assignee: Ohr Pharmaceutical Inc.
    Inventors: William A. Kinney, Xuehai Zhang, Ronald Michalak
  • Process for preparing beta-lactamase inhibitors
    Publication number: 20070149499
    Abstract: The present invention relates to processes for preparing ?-alkylidene penem derivatives that can be important as broad spectrum ?-lactamase inhibitors and anti-bacterial agents.
    Type: Application
    Filed: August 22, 2006
    Publication date: June 28, 2007
    Applicant: Wyeth
    Inventors: Ronald Michalak, Rocco Galante, David Blum, Julianne Blum, Lisa Routel, Haris Durutlic, Charles Guinosso, John Considine, Kenneth Kremer
  • Methods for preparing glutamic acid derivatives
    Publication number: 20070088172
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Application
    Filed: July 11, 2006
    Publication date: April 19, 2007
    Applicant: Wyeth
    Inventors: Ronald Michalak, Joseph Zeldis, Mel Jennings, David Blum, Timothy Doyle
  • Process for the synthesis of sulfonyl halides and sulfonamides from sulfonic acid salts
    Publication number: 20070021614
    Abstract: The present invention provides synthetic processes for the preparation of sulfonyl halides of Formula Ar—(R)z—O2—X and sulfonamides of Formula Ar—(R)2—SO2—NR4R5, where the constituent variables are as defined herein, that are useful as intermediates in the preparation of pharmaceuticals.
    Type: Application
    Filed: July 20, 2006
    Publication date: January 25, 2007
    Applicant: Wyeth
    Inventors: Ronald Michalak, Jean Helom, Joseph Zeldis
  • Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors
    Publication number: 20060041005
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Application
    Filed: August 18, 2005
    Publication date: February 23, 2006
    Applicant: Wyeth
    Inventors: Ronald Michalak, Mahmut Levent, Frederick Vyverberg, Ara Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Processes for the preparation of iodinated amino-aryl compounds
    Publication number: 20050215812
    Abstract: The present invention provides processes for the preparation of amino-aryl iodides wherein a micronized amino-aryl compound is reacted with an iodinating reagent.
    Type: Application
    Filed: March 24, 2005
    Publication date: September 29, 2005
    Applicant: Wyeth
    Inventor: Ronald Michalak
  • Processes for the preparation of aryl-and heteroaryl-alkylsulfonyl halides
    Publication number: 20050187408
    Abstract: The present invention provides processes for the preparation of arylalkylsulfonyl halides and heteroarylalkylsufonyl halides of Formula I: Ar—R—SO2—X, that are useful as intermediates in the preparation of pharmaceuticals.
    Type: Application
    Filed: February 23, 2005
    Publication date: August 25, 2005
    Applicant: Wyeth
    Inventors: Ronald Michalak, Mousumi Ghosh, Mahmut Levent
  • Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
    Publication number: 20050187202
    Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.
    Type: Application
    Filed: March 21, 2005
    Publication date: August 25, 2005
    Inventors: William Kinney, Xuehai Zhang, Ronald Michalak
  • Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
    Patent number: 6933383
    Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: August 23, 2005
    Assignee: Genaera Corporation
    Inventors: William A. Kinney, Xuehai Zhang, Ronald Michalak
  • Synthetic methodology for the reductive alkylation at the C-3 position of indoles
    Publication number: 20050148770
    Abstract: A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position.
    Type: Application
    Filed: December 16, 2004
    Publication date: July 7, 2005
    Applicant: Wyeth
    Inventors: Ronald Michalak, Panolil Raveendranath
  • Process for the synthesis of a CPLA2 inhibitor
    Publication number: 20050070723
    Abstract: A process for making a substituted indole compound, including the steps of: reacting the compounds in a non-protic polar solvent in the presence of a catalyst to form the intermediate compound wherein Ph and X are as defined herein; and then, heating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compound The invention also includes compounds formed by this process.
    Type: Application
    Filed: September 23, 2004
    Publication date: March 31, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Ronald Michalak, Panolil Raveendranath
  • Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile
    Publication number: 20050065181
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 24, 2005
    Applicant: Wyeth
    Inventors: Sylvain Daigneault, Ronald Michalak, Michel Bernatchez
  • Process for the synthesis of cPLA2 inhibitors
    Publication number: 20050049296
    Abstract: A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH2; Y represents C1-C6alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF3, OCF3, OH, C1-C6alkyl, C1-C6alkoxy, C1-C6thioalkyl, NH2, N(C1-C6alkyl)2, NH(C1-C6alkyl), NC(O)-(C1-C6alkyl), and NO2. In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).
    Type: Application
    Filed: August 31, 2004
    Publication date: March 3, 2005
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Ronald Michalak, Panolil Raveendranath, Jianxin Ren, Charles Wu, Yangzhong Wu
  • Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
    Publication number: 20030171576
    Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.
    Type: Application
    Filed: October 11, 2002
    Publication date: September 11, 2003
    Inventors: William A. Kinney, Xuehai Zhang, Ronald Michalak