Patents by Inventor Ronald Micura

Ronald Micura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Osmiumtetroxide-based conversion of RNA and DNA containing thiolated nucleotides
    Patent number: 11254982
    Abstract: Provided are compositions and methods for the conversion of thiolated nucleotides, and subsequent detection of the converted nucleotides in RNA or DNA. Also provided herein are compositions and methods for the metabolic labeling of RNA and DNA by incorporation of thiolated nucleotides, and their subsequent conversion and detection.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: February 22, 2022
    Assignees: UNIVERSITY OF INNSBRUCK, MEDICAL UNIVERSITY OF INNSBRUCK
    Inventors: Ronald Micura, Alexandra Lusser, Christian Riml, Thomas Amort, Catherina Gasser, Isabel Delazer
  • OSMIUMTETROXIDE-BASED CONVERSION OF RNA AND DNA CONTAINING THIOLATED NUCLEOTIDES
    Publication number: 20200048700
    Abstract: Provided are compositions and methods for the conversion of thiolated nucleotides, and subsequent detection of the converted nucleotides in RNA or DNA. Also provided herein are compositions and methods for the metabolic labeling of RNA and DNA by incorporation of thiolated nucleotides, and their subsequent conversion and detection.
    Type: Application
    Filed: August 7, 2019
    Publication date: February 13, 2020
    Inventors: Ronald MICURA, Alexandra LUSSER, Christian RIML, Thomas AMORT, Catherina GASSER, Isabel DELAZER
  • Methods and reagents for riboswitch analysis
    Patent number: 10421989
    Abstract: We provide isolated TPP and preQ1 class II riboswitches which are labelled for FRET studies of ribosome function. The riboswitches may be used in assays to determine riboswitch function, and to test the activity of compounds in modulating riboswitch function.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: September 24, 2019
    Assignees: CORNELL UNIVERSITY, UNIVERSITY OF INNSBRUCK
    Inventors: Scott Blanchard, Roger Altman, Marie F. Souliere, Ronald Micura, Andrea Haller
  • METHODS AND REAGENTS FOR RIBOSWITCH ANALYSIS
    Publication number: 20170183718
    Abstract: We provide isolated TPP and preQ1 class II riboswitches which are labelled for FRET studies of ribosome function. The riboswitches may be used in assays to determine riboswitch function, and to test the activity of compounds in modulating riboswitch function.
    Type: Application
    Filed: February 26, 2015
    Publication date: June 29, 2017
    Inventors: Scott BLANCHARD, Roger ALTMAN, Marie F. SOULIERE, Ronald MICURA, Andrea HALLER
  • Methods and reagents for analyzing riboswitches using FRET
    Patent number: 9303057
    Abstract: The present invention is provides isolated riboswitches with FRET pairs for distinguishing changes in regulatory interactions controlled by the expression platform domain found in riboswitches. The invention further provides methods of using those riboswitches to detect structural changes in the expression platform domain and to identify potential antibiotics.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: April 5, 2016
    Assignees: CORNELL UNIVERSITY, LEOPOLD-FRANZENS UNIVERSITAT INNSBRUCK
    Inventors: Scott C. Blanchard, Ronald Micura, Andrea Haller
  • METHODS AND REAGENTS FOR ANALYZING RIBOSWITCHES USING FRET
    Publication number: 20120276646
    Abstract: The present invention is provides isolated riboswitches with FRET pairs for distinguishing changes in regulatory interactions controlled by the expression platform domain found in riboswitches. The invention further provides methods of using those riboswitches to detect structural changes in the expression platform domain and to identify potential antibiotics.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 1, 2012
    Applicants: Leopold-Franzens Universitat Innsbruck, CORNELL UNIVERSITY
    Inventors: Scott C. Blanchard, Ronald Micura, Andrea Haller