Patents by Inventor Ronald N. Zuckermann

Ronald N. Zuckermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Side chain modified peptoids useful as structure-stabilizing coatings for biomaterials
    Patent number: 11739162
    Abstract: The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: August 29, 2023
    Assignees: Brookhaven Science Associates LLC, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California, The Trustees of Columbia University in the City of New York
    Inventors: Shih-Ting Wang, Oleg Gang, Ronald N. Zuckermann, Carolyn R. Bertozzi
  • SIDE CHAIN MODIFIED PEPTOIDS USEFUL AS STRUCTURE-STABILIZING COATINGS FOR BIOMATERIALS
    Publication number: 20210070886
    Abstract: The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).
    Type: Application
    Filed: September 9, 2020
    Publication date: March 11, 2021
    Inventors: Shih-Ting Wang, Oleg Gang, Ronald N. Zuckermann, Carolyn R. Bertozzi
  • Spectrally encoded microbeads and methods and devices for making and using same
    Patent number: 10241045
    Abstract: Spectrally encoded microbeads and methods and devices for making and using spectrally encoded microbeads are provided. The disclosed methods and devices facilitate the preparation and use of microbeads containing multiple lanthanide nanoparticles, which microbeads have uniquely identifiable spectral codes. The disclosed microbeads, and the methods and devices for making and using same, find use in multiplexing and high-throughput biomarker analysis.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: March 26, 2019
    Assignee: The Regents of the University of California
    Inventors: Brian Cullen Baxter, Joseph L. Derisi, Polly M. Fordyce, Rachel E. Gerver, Rafael Gòmez-Sjöberg, Brett A. Helms, Kurt S. Thorn, Ronald N. Zuckermann
  • Peptoids useful for the mineralization of apatite
    Patent number: 9764953
    Abstract: The present invention provides for a bio-mimetic polymer capable of catalyzing or mineralizing calcium ion and phosphate ions into an apatite.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: September 19, 2017
    Assignee: The Regents of the University of California
    Inventors: Ronald N. Zuckermann, James J. De Yoreo, Chun-Long Chen, Yung-Ching Chien, Grayson W. Marshall, Sally J. Marshall, Kuniko Saeki
  • SPECTRALLY ENCODED MICROBEADS AND METHODS AND DEVICES FOR MAKING AND USING SAME
    Publication number: 20150192518
    Abstract: Spectrally encoded microbeads and methods and devices for making and using spectrally encoded microbeads are provided. The disclosed methods and devices facilitate the preparation and use of microbeads containing multiple lanthanide nanoparticles, which microbeads have uniquely identifiable spectral codes. The disclosed microbeads, and the methods and devices for making and using same, find use in multiplexing and high-throughput biomarker analysis.
    Type: Application
    Filed: September 22, 2013
    Publication date: July 9, 2015
    Inventors: Brian Cullen Baxter, Joseph L. Derisi, Polly M. Fordyce, Rachel E. Gerver, Rafael Gòmez-Sjöberg, Brett A. Helms, Kurt S. Thorn, Ronald N. Zuckermann
  • Biomimetic peptoid polymers
    Patent number: 9073977
    Abstract: The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: July 7, 2015
    Assignee: The Regents of the University of California
    Inventors: Ronald N. Zuckermann, Tammy K. Chu, Ki Tae Nam
  • Peptoids Useful for the Mineralization of Apatite
    Publication number: 20150174197
    Abstract: The present invention provides for a bio-mimetic polymer capable of catalyzing or mineralizing calcium ion and phosphate ions into an apatite.
    Type: Application
    Filed: March 20, 2014
    Publication date: June 25, 2015
    Applicants: BATTELLE MEMORIAL INSTITUTE, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ronald N. Zuckermann, James J. De Yoreo, Chun-Long Chen, Yung-Ching Chien, Grayson W. Marshall, Sally J. Marshall, Kuniko Saeki
  • Peptoids useful for catalyzing the mineralization of calcium carbonate
    Patent number: 8952127
    Abstract: The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: February 10, 2015
    Assignee: The Regents of the University of California
    Inventors: Chun-Long Chen, Ronald N. Zuckermann, James J. De Yoreo
  • CELL TRANSFECTING FORMULATIONS OF SMALL INTERFERING RNA, RELATED COMPOSITIONS AND METHODS OF MAKING AND USE
    Publication number: 20150031743
    Abstract: Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
    Type: Application
    Filed: July 5, 2014
    Publication date: January 29, 2015
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
    Inventors: Timothy S. BURKOTH, Ann B. JEFFERSON, Christoph REINHARD, Ronald N ZUCKERMANN
  • Cell transfecting formulations of small interfering RNA related compositions and methods of making and use
    Patent number: 8772255
    Abstract: Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: July 8, 2014
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Timothy S. Burkoth, Anne B. Jefferson, Christoph Reinhard, Ronald N. Zuckermann
  • Polypeptoid pulmonary surfactants
    Patent number: 8673842
    Abstract: The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: March 18, 2014
    Assignees: Chiron Corporation
    Inventors: Annelise E. Barron, Ronald N. Zuckermann, Cindy W. Wu
  • Selective Poly-N-Substituted Glycine Antibiotics
    Publication number: 20140031523
    Abstract: Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.
    Type: Application
    Filed: May 20, 2013
    Publication date: January 30, 2014
    Inventors: Annelise E. Barron, Ronald N. Zuckermann, Ann M. Czyzewski, Michelle T. Dohm, Tyler M. Miller, James A. Patch, Nathaniel P. Chongsiriwatana
  • Selective poly-N-substituted glycine antibiotics
    Patent number: 8445632
    Abstract: Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: May 21, 2013
    Assignees: The Regents of the University of California, Northwestern University
    Inventors: Annelise E. Barron, Ann M. Czyzewski, Michelle T. Dohm, Tyler M. Miller, Ronald N. Zuckermann, James A. Patch, Nathaniel P. Chongsiriwatana
  • Selective poly-substituted glycine antibiotics and related compositions
    Publication number: 20120295838
    Abstract: Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.
    Type: Application
    Filed: February 6, 2012
    Publication date: November 22, 2012
    Inventors: Annelise E. Barron, Ronald N. Zuckermann, Ann M. Czyzewski, Michelle T. Dohm, Tyler M. Miller, James A. Patch, Nathaniel P. Chongsiriwatana
  • Polypeptoid pulmonary surfactants
    Publication number: 20120258918
    Abstract: The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
    Type: Application
    Filed: February 13, 2012
    Publication date: October 11, 2012
    Inventors: Annelise E. Barron, Ronald N. Zuckermann, Cindy W. Wu
  • Novel biomimetic peptoid polymers
    Publication number: 20120046443
    Abstract: The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.
    Type: Application
    Filed: February 7, 2011
    Publication date: February 23, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ronald N. Zuckermann, Tammy K. Chu, Ki Tae Nam
  • Polypeptoid pulmonary surfactants
    Patent number: 8114830
    Abstract: The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: February 14, 2012
    Assignees: Northwestern University, Chiron Corporation
    Inventors: Annelise E. Barron, Ronald N. Zuckermann, Cindy W. Wu
  • Peptoids Useful for Catalyzing the Mineralization of Calcium Carbonate
    Publication number: 20110300053
    Abstract: The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 8, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chun-Long Chen, Ronald N. Zuckermann, James J. De Yoreo
  • Fluorogenic dyes
    Patent number: 7704756
    Abstract: Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: April 27, 2010
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Daniel J. Suich, Ronald N. Zuckermann
  • Selective poly-N-substituted glycine antibiotics
    Publication number: 20100036088
    Abstract: Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.
    Type: Application
    Filed: February 9, 2009
    Publication date: February 11, 2010
    Inventors: Annelise E. Barron, Ann M. Czyzewski, Michelle T. Dohm, Tyler M. Miller, Ronald N. Zuckermann, James A. Patch, Nathaniel P. Chongsiriwatana