Patents by Inventor Ronald Nixon Keener, III

Ronald Nixon Keener, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REFOLDING PROTEINS USING A CHEMICALLY CONTROLLED REDOX STATE
    Publication number: 20190055281
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: February 6, 2018
    Publication date: February 21, 2019
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Refolding proteins using a chemically controlled redox state
    Patent number: 9856287
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: January 2, 2018
    Assignee: Amgen Inc.
    Inventors: Joseph Edward Shultz, Roger Hart, Ronald Nixon Keener, III
  • REFOLDING PROTEINS USING A CHEMICALLY CONTROLLED REDOX STATE
    Publication number: 20170145049
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: February 1, 2017
    Publication date: May 25, 2017
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Refolding Proteins Using a Chemically Controlled Redox State
    Publication number: 20150329586
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L, or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox butler strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: July 7, 2015
    Publication date: November 19, 2015
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Refolding Proteins Using a Chemically Controlled Redox State
    Publication number: 20150315232
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying foe thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: January 30, 2015
    Publication date: November 5, 2015
    Inventors: Joseph Edward SHULTZ, Roger HART, Ronald Nixon KEENER, III
  • Refolding proteins using a chemically controlled redox state
    Patent number: 8952138
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: February 10, 2015
    Assignee: Amgen Inc.
    Inventors: Joseph Edward Shultz, Roger Hart, Ronald Nixon Keener, III
  • REFOLDING PROTEINS USING A CHEMICALLY CONTROLLED REDOX STATE
    Publication number: 20100324269
    Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.
    Type: Application
    Filed: June 21, 2010
    Publication date: December 23, 2010
    Applicant: AMGEN INC.
    Inventors: Joseph Edward Shultz, Roger Hart, Ronald Nixon Keener, III