Abstract: Provided herein are methods of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa (ONLC) complex in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the ONLC of the individual. In a particular embodiment, the invention is directed to methods of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucoma in the individual.

Abstract: Provided herein are methods of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa (ONLC) complex in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the ONLC of the individual. In a particular embodiment, the invention is directed to methods of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucoma in the individual.

Abstract: Systems and methods are provided for disrupting tissue within preretinal or retinal structures of an eye. At least one femtosecond laser pulse is directed through the cornea of the eye to a target location. The at least one femtosecond laser pulse has sufficient intensity to induce nonlinear absorption in tissue within the target location. The at least one laser pulse is corrected at an adaptive optical element as to substantially reduce dispersion and aberration of the at least one laser pulse due to changes in the wavefront profile associated with the laser pulse due to travel through eye tissue between the surface of the eye and the target location. At least the target location is imaged to produce an in vivo image of the target location. The adaptive optical element is adjusted according to distortion detected in a reflected wavefront.

Abstract: A pressure gage adapted to provide a mechanical indication of a sensed pressure and to provide an electrical signal indicative of the sensed pressure. The pressure gage includes a housing having a first fluid pressure chamber, a second fluid pressure chamber, and flexible diaphragm separating the first fluid pressure chamber from the second fluid pressure chamber. A magnet is coupled to the diaphragm such that movement of the diaphragm causes a related movement of the magnet. A helix is located adjacent to the magnet and a pointer is attached to the helix for conjoint rotation with a helix about a rotational axis. A Hall effect sensor is also located adjacent the magnet. Movement of the magnet in response to movement of the diaphragm rotates the helix and the pointer to provide a mechanical indication of the pressure sensed by the diaphragm, and the movement of the magnet causes the Hall effect sensor to generate an electrical signal indicative of the pressure sensed by the diaphragm.

Abstract: A pressure gage adapted to provide a mechanical indication of a sensed pressure and to provide an electrical signal indicative of the sensed pressure. The pressure gage includes a housing having a first fluid pressure chamber, a second fluid pressure chamber, and flexible diaphragm separating the first fluid pressure chamber from the second fluid pressure chamber. A magnet is coupled to the diaphragm such that movement of the diaphragm causes a related movement of the magnet. A helix is located adjacent to the magnet and a pointer is attached to the helix for conjoint rotation with a helix about a rotational axis. A Hall effect sensor is also located adjacent the magnet. Movement of the magnet in response to movement of the diaphragm rotates the helix and the pointer to provide a mechanical indication of the pressure sensed by the diaphragm, and the movement of the magnet causes the Hall effect sensor to generate an electrical signal indicative of the pressure sensed by the diaphragm.

Abstract: A differential pressure switch comprising an enclosure including a peripheral wall and a solid one-piece non-perforate partition wall that is integrally attached to the peripheral wall around the entire perimeter of the partition wall. The enclosure includes a sensor chamber located on a first side of the partition wall and a fluid cavity located on a second side of the partition wall. The partition wall and the integrally attached peripheral wall seal the sensor chamber in fluid-tight leak-proof isolation from the fluid cavity. A flexible diaphragm is located within the fluid cavity and forms a low-pressure fluid chamber on one side and a high-pressure fluid chamber on a second side of the diaphragm. A magnet is located in the fluid cavity and is coupled to the diaphragm such that the magnet changes position in response to movement of the diaphragm. A Hall effect sensor is located in the sensor chamber.