Abstract: The present invention relates generally to components for the fabrication of microfluidic systems, particularly to components and combinations of components for the rapid and robust fabrication of prototype microfluidic systems, and to components allowing the positioning of microfluidic devices or components for subsequent encapsulation. A design for a prototyping platform, fittings, interconnects, and other components are described having structures such that flexible assembly into a virtually unlimited array of possible prototype systems is both feasible and efficient.

Abstract: Microliter scale solid phase extraction devices for preparing analytes in microliter volumes are disclosed. A re-useable device is provided in cartridge form that includes a central containment member with a containment bore that holds as little as 1 to 5 ?l or less of a solid phase material that binds the analyte. The containment bore is enclosed on either side by a porous membrane that has an inner portion exposed for fluid flow and a peripheral portion that is sealed against fluid flow. The seal is formed by engaging the periphery of the porous membranes between sealing surfaces of the central containment member and corresponding sealing surfaces on first and second conduit assemblies that comprise the remainder of the cartridge. A non-reuseable device is provided in “chip” form, which includes a porous filter sandwiched between top and bottom wafers each having a plurality corresponding input and output conduits for a plurality of samples.

Abstract: Injection molding is used to form microfluidic devices with integrated functional components. One or more functional components are placed in a mold cavity which is then closed. Molten thermoplastic resin is injected into the mold and then cooled, thereby forming a solid substrate including the functional component(s). The solid substrate including the functional component(s) is then bonded to a second substrate which may include microchannels or other features.

Abstract: Disclosed are microflulidic chips that include a plurality of vias; a functionalized porous polymer monolith capable of being in fluid communication with a via; a microarray capable of being in fluid communication with the functionalized porous polymer monolith; and an observation port through which at least one target disposed within the microarray is capable of being detected. The disclosed microfluidic chips contain microarrays that can be effectively coupled to functionalized porous polymer monoliths for capturing and concentrating sample nucleic acids. Also disclosed are microfluidic chips containing microarray probes having observation ports that enable the preparation of microarrays and the detection of targets. These microfluidic chips are capable of capturing and concentrating genetic material for the analysis and identification of biological organisms, such as so-called “threat genes” from chimeric bioweapons.

Abstract: A modular optical detector system. The detector system is designed to detect the presence of molecules or molecular species by inducing fluorescence with exciting radiation and detecting the emitted fluorescence. Because the system is capable of accurately detecting and measuring picomolar concentrations it is ideally suited for use with microchemical analysis systems generally and capillary chromatographic systems in particular. By employing a modular design, the detector system provides both the ability to replace various elements of the detector system without requiring extensive realignment or recalibration of the components as well as minimal user interaction with the system. In addition, the modular concept provides for the use and addition of a wide variety of components, including optical elements (lenses and filters), light sources, and detection means, to fit particular needs.

Abstract: The present invention provides systems and processes for the collection and identification of macromolecules, such as biologically-derived macromolecules (e.g., proteins and nucleic acids), by measuring and comparing the molecular weight signatures of macromolecular samples. Reproducible molecular weight signatures provides reliable sample identification. In the case of viruses, proteomic molecular weight signatures can be used for identifying viral agents.

Abstract: A method for providing a realistic sense of touch in virtual reality by means of programmable actuator assemblies is disclosed. Each tactile actuator assembly consists of a number of individual actuators whose movement is controlled by a computer and associated drive electronics. When an actuator is energized, the rare earth magnet and the associated contactor, incorporated within the actuator, are set in motion by the opposing electromagnetic field of a surrounding coil. The magnet pushes the contactor forward to contact the skin resulting in the sensation of touch. When the electromagnetic field is turned off, the rare earth magnet and the contactor return to their neutral positions due to the magnetic equilibrium caused by the interaction with the ferrous outer sleeve. The small size and flexible nature of the actuator assemblies permit incorporation into a glove, boot or body suit.