Patents by Inventor Ronald S. Michalak

Ronald S. Michalak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as cPLAinhibitors
    Patent number: 8034960
    Abstract: The present invention provides a compound of formula 1: wherein R1 is CF3, R2 is H? R3 is H.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: October 11, 2011
    Assignee: Pfizer Inc.
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As CPLA2 Inhibitors
    Publication number: 20110054189
    Abstract: The present invention provides a compound of formula 1: wherein R1 is CF3, R2 is H, R3 is H, and R4 is H.
    Type: Application
    Filed: November 11, 2010
    Publication date: March 3, 2011
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process for the synthesis of sulfonyl halides and sulfonamides from sulfonic acid salts
    Patent number: 7842834
    Abstract: The present invention provides synthetic processes for the preparation of sulfonyl halides of Formula Ar—(R)z—SO2—X and sulfonamides of Formula Ar—(R)z—SO2—NR4R5, where the constituent variables are as defined herein, that are useful as intermediates in the preparation of pharmaceuticals.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: November 30, 2010
    Assignee: Wyeth LLC
    Inventors: Ronald S. Michalak, Jean L. Helom, Joseph Zeldis
  • Process for the synthesis of C-2, C-3 substituted N-alkylated indoles useful as cPLAinhibitors
    Patent number: 7842837
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: November 30, 2010
    Assignee: Wyeth LLC
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Synthetic methodology for the reductive alkylation at the C-3 position of indoles
    Patent number: 7709661
    Abstract: A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: May 4, 2010
    Assignee: Wyeth LLC
    Inventors: Ronald S. Michalak, Panolil Raveendranath
  • Process for the Synthesis of C-2, C-3 Substituted N-Alkylated Indoles Useful as cPLA2 Inhibitors
    Publication number: 20090306428
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Application
    Filed: August 18, 2009
    Publication date: December 10, 2009
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLAinhibitors
    Patent number: 7582772
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: September 1, 2009
    Assignee: Wyeth
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process for the synthesis of cPLA inhibitors
    Patent number: 7582771
    Abstract: A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH2; Y represents C1-C6alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF3, OCF3, OH, C1-C6alkyl, C1-C6alkoxy, C1-C6thioalkyl, NH2, N(C1-C6alkyl)2, NH(C1-C6alkyl), NC(O)—(C1C6alkyl), and NO2. In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: September 1, 2009
    Assignee: Wyeth
    Inventors: Christoph M. Dehnhardt, Sreenivasulu Megati, Ronald S. Michalak, Panolil Raveendranath, Jianxin Ren, Charles C. Wu, Yangzhong Wu
  • Methods for preparing glutamic acid derivatives
    Patent number: 7541485
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: June 2, 2009
    Assignee: Wyeth
    Inventors: Ronald S. Michalak, Joseph Zeldis, Mel Jennings, David M. Blum, Timothy Doyle
  • Process for the Synthesis of a CPLA2 Inhibitor
    Publication number: 20080177085
    Abstract: A process for making a substituted indole compound, including the steps of: reacting the compounds in a non-protic polar solvent in the presence of a catalyst to form the intermediate compound wherein Ph and X are as defined herein; and then, heating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compound The invention also includes compounds formed by this process.
    Type: Application
    Filed: March 4, 2008
    Publication date: July 24, 2008
    Inventors: Christoph M. Dehnhardt, Sreenivasulu Megati, Ronald S. Michalak, Panolil Raveendranath
  • SYNTHETIC METHODOLOGY FOR THE REDUCTIVE ALKYLATION AT THE C-3 POSITION OF INDOLES
    Publication number: 20080161581
    Abstract: A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position.
    Type: Application
    Filed: October 15, 2007
    Publication date: July 3, 2008
    Inventors: Ronald S. Michalak, Panolil Raveendranath
  • Methods for preparing glutamic acid derivatives and intermediates thereof
    Publication number: 20080119670
    Abstract: The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
    Type: Application
    Filed: June 1, 2007
    Publication date: May 22, 2008
    Applicant: Wyeth
    Inventors: Timothy Doyle, Joseph Zeldis, Ronald S. Michalak, David M. Blum, Mel Jennings, Julianne Blum
  • Process for the synthesis of a CPLAinhibitor
    Patent number: 7342119
    Abstract: A process for making a substituted indole compound, including the steps of: reacting the compounds in a non-protic polar solvent in the presence of a catalyst to form the intermediate compound wherein Ph and X are as defined herein; and then, heating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compound The invention also includes compounds formed by this process.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: March 11, 2008
    Inventors: Christoph M. Dehnhardt, Sreenivasulu Megati, Ronald S. Michalak, Panolil Raveendranath
  • Processes for the preparation of aryl- and heteroaryl-alkylsulfonyl halides
    Patent number: 7321061
    Abstract: The present invention provides processes for the preparation of arylalkylsulfonyl halides and heteroarylalkylsufonyl halides of Formula I: Ar—R—SO2—X, that are useful as intermediates in the preparation of pharmaceuticals.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: January 22, 2008
    Assignee: Wyeth
    Inventors: Ronald S. Michalak, Mousumi Ghosh, Mahmut Levent
  • Synthetic methodology for the reductive alkylation at the C-3 position of indoles
    Patent number: 7282594
    Abstract: A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: October 16, 2007
    Assignee: Wyeth
    Inventors: Ronald S. Michalak, Panolil Raveendranath