Patents by Inventor Ronald Stanley Michalak

Ronald Stanley Michalak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMORPHS OF N2-(1,1'-BIPHENYL-4-YLCARBONYL)-N1-[2-(4-FLUOROPHENYL)-1,1-DIMETHYLETHYL]-L-ALPHA-GLUTAMINE
    Publication number: 20100216886
    Abstract: Disclosed are novel polymorphic forms of N2-(1,1?-biphenyl-4-ylcarbonyl)-N1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-L-?-glutamine, methods of preparing the polymorphic forms, compositions containing the polymorphic forms, and methods of treatment using the polymorphic forms.
    Type: Application
    Filed: November 9, 2007
    Publication date: August 26, 2010
    Applicant: Wyeth
    Inventors: Qiuxia Wang, Jennifer Qianying Liang, Mannching Sherry Ku, Ronald Stanley Michalak, Wen James Huang
  • SELECTIVE ACYLATION OF 4-SUBSTITUTED-1,3-PHENYLENEDIAMINE
    Publication number: 20090216046
    Abstract: This invention is directed to a method of selectively acylating a compound of formula (II): (II), wherein: R1 is NO2, —N+R33, trihalomethyl, —CN, —SO3H, —CO2H, —CO2 R3, —CHO and —COR3, wherein R3 is C1-C6 alkyl, C1-C6 haloalkyl, C3-C12 cycloalkyl, C6-C12 aryl, C2-C9 heteroaryl, or C1-C9 heterocycloalkyl; comprising the step of reacting the compound of formula (II) with an acylating reagent to form a compound of formula (I): (I), wherein R2 is selected from C1-C12 alkyl, C1-C12 haloalkyl, C2-C7 alkenyl, C2-C7 alkynyl, C3-C12 cycloalkyl, C6-C12 aryl, C1-C9 heterocycloalkyl, C2-C9 heteroaryl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C12 cycloalkoxy, C1-C9 heterocycloalkoxy, C6-C12 aryloxy, and C2-C9 heteroaryloxy; or salts thereof.
    Type: Application
    Filed: October 12, 2006
    Publication date: August 27, 2009
    Applicant: WYETH
    Inventor: Ronald Stanley Michalak
  • Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile
    Publication number: 20080161575
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Application
    Filed: March 10, 2008
    Publication date: July 3, 2008
    Applicant: Wyeth
    Inventors: Sylvain Daigneault, Ronald Stanley Michalak, Michel Bernatchez
  • Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile
    Patent number: 7365203
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Sylvain Daigneault, Ronald Stanley Michalak, Michel Bernatchez