Abstract: A digital pathology system for recording and displaying field of view portions that have been viewed in the context of developing a diagnosis for a pathology case. A whole slide image is presented with shading overlaid on the image illustrating those portions that have been viewed. Portions of the WSI that have received the pathologist's attention at different magnifications are marked with distinguishing hatching.

Abstract: A system and method of increasing digital pathology productivity is provided. The system accepts case information from a plurality of sources and pre-processes that information in order to present the slides in an order and orientation dictated by preference and/or reviewing standard. Upon application of the system and method, the appearance and behavior of the user interface is optimized for the user.

Abstract: A system and method of increasing digital pathology productivity is provided. The system accepts case information from a plurality of sources and pre-processes that information in order to present the slides in an order and orientation dictated by preference and/or reviewing standard. Upon application of the system and method, the appearance and behavior of the user interface is optimized for the user.

Abstract: A method and apparatus are disclosed for providing additional information, such as advertisements, to a client device via the response signal to an application (or web) server request. A client device is in communication with a server device, and sends a request for information to the server via a network connection. A device is associated with the network connection that detects and analyzes the signals being exchanged. The device would likely be associated with a point-of-presence to an Internet connection, for an ISP or the like. The associated device sends an appropriately timed reset signal to the server device that prevents the server device from further responding to signals subsequently received from the client device. The associated device sends, in response to the web server request, a response signal to the client device. The response signal provides additional information, along with the originally requested web server material.

Abstract: A physics based model of the absorption of light by histological stains used to measure the amount of one or more stains at locations within tissue is disclosed. The subsequent analysis results in several improvements in the detection of tissue on a slide, improvements to autofocus algorithms so focusing during image acquisition is confined to tissue, improvements to image segmentation and identification of tissued and its features, improvements to the identification of stain where multiple stains are used, and improvements to the quantification of the extent of staining. The invention relates to the application of these improvements to stain detection and quantification to provide for objective comparison between tissues and closer correlation between the presentations of such features and concurrent patterns of gene or protein expression.

Abstract: We disclose a method for the correlation of structural feature information derived from digital images of a diagnostic set of histopathological tissue specimens from a group of subjects with shared characteristics and molecular activity (which may be either gene or protein expression) information derived from related specimens of the same set to provide for the objective characterization and analysis of the variability of tissue structural features in relation to such molecular activity (the product of such correlation referred to herein as the “correlated tissue information”). Such correlated tissue information allows for comparison and combination with correlated tissue information obtained through studies taking place at different times, with different protocols for the collection, preservation, histological staining and molecular activity assays of the tissue.

Abstract: A physics based model of the absorption of light by histological stains used to measure the amount of one or more stains at locations within tissue is disclosed. The subsequent analysis results in several improvements in the detection of tissue on a slide, improvements to autofocus algorithms so focusing during image acquisition is confined to tissue, improvements to image segmentation and identification of tissued and its features, improvements to the identification of stain where multiple stains are used, and improvements to the quantification of the extent of staining. The invention relates to the application of these improvements to stain detection and quantification to provide for objective comparison between tissues and closer correlation between the presentations of such features and concurrent patterns of gene or protein expression.

Abstract: A physics based model of the absorption of light by histological stains used to measure the amount of one or more stains at locations within tissue is disclosed. The subsequent analysis results in several improvements in the detection of tissue on a slide, improvements to autofocus algorithms so focusing during image acquisition is confined to tissue, improvements to image segmentation and identification of tissued and its features, improvements to the identification of stain where multiple stains are used, and improvements to the quantification of the extent of staining. The invention relates to the application of these improvements to stain detection and quantification to provide for objective comparison between tissues and closer correlation between the presentations of such features and concurrent patterns of gene or protein expression.

Abstract: We disclose quantitative geometrical analysis enabling the measurement of several features of images of tissues including number, size, density of extracted hepatocyte nuclei, and other metrics. Automation of feature extraction creates a high throughput capability that enables analysis of histologically prepared tissue sections for accurate quantification of extracted features from tissues. Measurement results are input into a relational database where they can be statistically analyzed and compared across studies. As part of the integrated process, results are also imprinted on the images themselves to facilitate auditing of the results. The analysis is objective, fast, repeatable and accurate and provides an alternative or supplement to the subjective analysis of tissue slides by a pathologist.

Abstract: A physics based model of the absorption of light by histological stains used to measure the amount of one or more stains at locations within tissue is disclosed. The subsequent analysis results in several improvements in the detection of tissue on a slide, improvements to autofocus algorithms so focusing during image acquisition is confined to tissue, improvements to image segmentation and identification of tissued and its features, improvements to the identification of stain where multiple stains are used, and improvements to the quantification of the extent of staining. The invention relates to the application of these improvements to stain detection and quantification to provide for objective comparison between tissues and closer correlation between the presentations of such features and concurrent patterns of gene or protein expression.

Abstract: A ball throwing machine includes a ball throwing mechanism that is mounted on a frame that rotates about a vertical axis so that balls are ejected at preset positions along an arc. In a preferred embodiment, the ball throwing mechanism is mounted on a base plate that rotates back and forth through a 90-degree arc. A timing plate controls the rotation of the throwing mechanism and includes projections that trigger the ejection of the balls at preselected angular positions.

Abstract: A paper web formation measurement system provides on-line measurement and control of visual properties of a moving web of paper. The measurement system includes an image acquisition system for capturing images of the moving web, and an image analysis system for analyzing captured images. The image acquisition system includes a strobe lighting system for backlighting the moving web and a charge injection device (CID) camera for capturing light transmitted through the web to form an image of the web in non-standard (non-RS-170), full frame format. Captured images are digitized by the image analysis system to 256 graylevel and analyzed to produce a mathematical formation index representing visual properties of the web. The mathematical formation index, which is derived from a graylevel distribution histogram, is presented to paper production personnel to enable on-line adjustment of process variables to maximize paper quality.