Patents by Inventor Ronald Tuccelli
Ronald Tuccelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11732003Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.Type: GrantFiled: April 18, 2018Date of Patent: August 22, 2023Assignee: EMD Millipore CorporationInventors: Ronald Tuccelli, John Caulmare, Luc Messier, Melissa Holstein, Christopher Gillespie, Roger Hill
-
Patent number: 11547957Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.Type: GrantFiled: April 18, 2018Date of Patent: January 10, 2023Assignee: EMD Millipore CorporationInventors: Ronald Tuccelli, John Caulmare, Melissa Holstein, Kristen Cotoni, Christopher Gillespie
-
Publication number: 20200172568Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.Type: ApplicationFiled: April 18, 2018Publication date: June 4, 2020Inventors: Ronald Tuccelli, John Caulmare, Luc Messier, Melissa Holstein, Christopher Gillespie, Roger Hill
-
Publication number: 20200061495Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.Type: ApplicationFiled: April 18, 2018Publication date: February 27, 2020Inventors: Ronald Tuccelli, John Caulmare, Melissa Holstein, Kristen Cotoni, Christopher Gillespie
-
Patent number: 9777847Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).Type: GrantFiled: July 18, 2013Date of Patent: October 3, 2017Assignee: EMD Millipore CorporationInventors: Ronald Tuccelli, Sebastien Cirou, Virginie Buisson, Christine Abouayad El Idrissi, Jim Kelly
-
Patent number: 9677675Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).Type: GrantFiled: July 18, 2013Date of Patent: June 13, 2017Assignee: EMD Millipore CorporationInventors: Ronald Tuccelli, Sebastien Cirou, Virginie Buisson, Christine Abouayad El Idrissi, Jim Kelly
-
Patent number: 9259733Abstract: The invention concerns a device comprising a circuit comprising a bag (10) comprising two flexible films (65, 66), a press (9) comprising a first shell (16) disposed upright on a front face of a base of the device and a second shell (17) mounted on said first shell, which shells clamp said bag to form conduits (13); said press is provided with a system (170) for jamming at the location of a treatment zone (67) of the bag, which comprises a jamming member (171) provided with at least one jamming nipple (173) and a complementary jamming member (172) provided with a jamming channel (174) configured to receive said nipple; said jamming member (171) and complementary jamming member (172) and said bag (10) being configured in order for the latter to have a portion (175) in said treatment zone in which said films are jammed between said nipple and said channel.Type: GrantFiled: July 18, 2013Date of Patent: February 16, 2016Assignee: EMD Millipore CorporationInventors: Ronald Tuccelli, Sebastien Cirou, Virginie Buisson, Christine Abouayad El Idrissi, Jim Kelly
-
Patent number: 9108138Abstract: The invention relates to accelerated mixed gas integrity testing methods, devices, and systems for integrity testing wetted single and multi-layered porous materials, whereby the testing method is non-destructive to the porous materials being tested. The accelerated mixed gas integrity test method includes one or more of the following components: i) a permeate side gas purge component; ii) a permeate side volume reduction component; and iii) a permeate side circulation component. The invention is directed towards reducing the length of time necessary to complete the integrity testing of single and multi layered porous materials, elements and membranes.Type: GrantFiled: January 24, 2012Date of Patent: August 18, 2015Assignee: EMD Millipore CorporationInventors: Jibin Hao, Salvatore Giglia, Michael Joens, Ronald Tuccelli
-
Publication number: 20150204450Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).Type: ApplicationFiled: July 18, 2013Publication date: July 23, 2015Inventors: Ronald Tuccelli, Sebastien Cirou, Virginie Buisson, Christine Abouayad El Idrissi, Jim Kelly
-
Publication number: 20150190809Abstract: The invention concerns a device comprising a circuit comprising a bag (10) comprising two flexible films (65, 66), a press (9) comprising a first shell (16) disposed upright on a front face of a base of the device and a second shell (17) mounted on said first shell, which shells clamp said bag to form conduits (13); said press is provided with a system (170) for jamming at the location of a treatment zone (67) of the bag, which comprises a jamming member (171) provided with at least one jamming nipple (173) and a complementary jamming member (172) provided with a jamming channel (174) configured to receive said nipple; said jamming member (171) and complementary jamming member (172) and said bag (10) being configured in order for the latter to have a portion (175) in said treatment zone in which said films are jammed between said nipple and said channel.Type: ApplicationFiled: July 18, 2013Publication date: July 9, 2015Inventors: Ronald Tuccelli, Sebastien Cirou, Virginie Buisson, Christine Abouayad El Idrissi, Jim Kelly
-
Publication number: 20130019658Abstract: The invention relates to accelerated mixed gas integrity testing methods, devices, and systems for integrity testing wetted single and multi-layered porous materials, whereby the testing method is non-destructive to the porous materials being tested. The accelerated mixed gas integrity test method includes one or more of the following components: i) a permeate side gas purge component; ii) a permeate side volume reduction component; and iii) a permeate side circulation component. The invention is directed towards reducing the length of time necessary to complete the integrity testing of single and multi layered porous materials, elements and membranes.Type: ApplicationFiled: January 24, 2012Publication date: January 24, 2013Applicant: EMD Millipore CorporationInventors: Jibin Hao, Salvatore Giglia, Michael Joens, Ronald Tuccelli
-
Patent number: 7560024Abstract: This invention provides for a method to control the pore size or bubble point of porous membranes made by phase inversion in a continuous manufacturing process by blending two or more solutions each capable of producing a porous membrane with different pore size or bubble point than the pore size or bubble point of the desired membrane, and blending these solutions by the method of this invention to produce the desired pore size or bubble point. This invention also provides for a method to monitor membrane pore size in a continuous process and adjust pore size during the continuous manufacturing process.Type: GrantFiled: April 21, 2003Date of Patent: July 14, 2009Assignee: Millipore CorporationInventors: Willem Franciscus Catherina Kools, Ronald Tuccelli, Gabriel Tkacik
-
Publication number: 20030214066Abstract: This invention provides for a method to control the pore size or bubble point of porous membranes made by phase inversion in a continuous manufacturing process by blending two or more solutions each capable of producing a porous membrane with different pore size or bubble point than the pore size or bubble point of the desired membrane, and blending these solutions by the method of this invention to produce the desired pore size or bubble point. This invention also provides for a method to monitor membrane pore size in a continuous process and adjust pore size during the continuous manufacturing process.Type: ApplicationFiled: April 21, 2003Publication date: November 20, 2003Inventors: Willem Franciscus Catherina Kools, Ronald Tuccelli, Gabriel Tkacik
-
Patent number: 5522991Abstract: A cellulosic ultrafiltration membrane is provided having a microporous base resistant substrate and an ultrafiltration layer form of a cellulose ester or cellulose.Type: GrantFiled: July 20, 1994Date of Patent: June 4, 1996Assignee: Millipore Investment Holdings LimitedInventors: Ronald Tuccelli, Paul V. McGrath