Patents by Inventor Ronald W. Barrett

Ronald W. Barrett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treating urinary incontinence using prodrugs of GABA analogs
    Patent number: 7700652
    Abstract: Disclosed herein are methods of using prodrugs of GABA analogs and pharmaceutical compositions thereof to treat and/or prevent urinary incontinence in humans, and pharmaceutical compositions of prodrugs of GABA analogs useful in treating and/or preventing urinary incontinence.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: April 20, 2010
    Assignee: XenoPort, Inc.
    Inventor: Ronald W. Barrett
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7645797
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: January 12, 2010
    Assignee: XenoPort, Inc.
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • COMPOUNDS DISPLAYED ON REPLICABLE GENETIC PACKAGES AND METHODS OF USING SAME
    Publication number: 20090233808
    Abstract: Replicable genetic packages and collections thereof that display various compounds are provided. In some instances, the replicable genetic packages include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the replicable genetic package. The invention further provides a number of different methods for using the replicable genetic packages to screen a library of compounds for a desired biological activity.
    Type: Application
    Filed: February 27, 2009
    Publication date: September 17, 2009
    Applicant: XenoPort, Inc.
    Inventors: Ronald W. Barrett, William J. Dower, Mark Gallop, Thomas F. Woiwode, Steven E. Cwirla
  • SUBSTRATES AND SCREENING METHODS FOR TRANSPORT PROTEINS
    Publication number: 20090221442
    Abstract: A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
    Type: Application
    Filed: July 14, 2008
    Publication date: September 3, 2009
    Applicant: XenoPort, Inc.
    Inventors: William J. Dower, Mark Gallop, Ronald W. Barrett, Kenneth C. Cundy, Tania Chernov-Rogan
  • CRYSTALLINE FORM OF A (3S)-AMINOMETHYL-5-METHYL-HEXANOIC ACID PRODRUG AND METHODS OF USE
    Publication number: 20090215809
    Abstract: A crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug and methods of preparing a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug, and methods of using a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug are provided.
    Type: Application
    Filed: January 23, 2009
    Publication date: August 27, 2009
    Applicant: XenoPort, Inc.
    Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
  • PEPTIDES AND COMPOUNDS THAT BIND TO A RECEPTOR
    Publication number: 20090214489
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Application
    Filed: April 15, 2008
    Publication date: August 27, 2009
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, David J. Duffin, Christian M. Gates, Sherril S. Haselden, Larry C. Mattheakis, Peter J. Schatz, Christopher R. Wagstrom, Nicholas C. Wrighton
  • MESOPHASIC FORMS OF (3S)-AMINOMETHYL-5-METHYL-HEXANOIC ACID PRODRUGS AND METHODS OF USE
    Publication number: 20090192222
    Abstract: Mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs and methods of preparing and methods of using mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs are provided.
    Type: Application
    Filed: January 23, 2009
    Publication date: July 30, 2009
    Applicant: XenoPort, Inc.
    Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
  • Compounds displayed on replicable genetic packages and methods of using same
    Patent number: 7517643
    Abstract: Replicable genetic packages and collections thereof that display various compounds are provided. In some instances, the replicable genetic packages include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the replicable genetic package. The invention further provides a number of different methods for using the replicable genetic packages to screen a library of compounds for a desired biological activity.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: April 14, 2009
    Assignee: XenoPort, Inc.
    Inventors: Ronald W. Barrett, William J. Dower, Mark Gallop, Thomas F. Woiwode, Steven E. Cwirla
  • AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATION OF GABA ANALOGUES
    Publication number: 20080226716
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Application
    Filed: May 28, 2008
    Publication date: September 18, 2008
    Applicant: XenoPort
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7420002
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: September 2, 2008
    Assignee: Xenoport
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • Substrates and screening methods for transport proteins
    Patent number: 7413536
    Abstract: A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: August 19, 2008
    Assignee: XenoPort, Inc.
    Inventors: William J. Dower, Mark A. Gallop, Ronald W. Barrett, Kenneth C. Cundy, Tania Chernov-Rogan
  • Use of prodrugs of GABA analogs for treating disease
    Publication number: 20080161393
    Abstract: Methods of using prodrugs of GABA analogs and pharmaceutical compositions thereof to treat migraine, fibromyalgia, amyotrophic lateral sclerosis, irritable bowel syndrome, social phobia, Parkinson's disease, asthma, cough, or chronic obstructive pulmonary disease, and pharmaceutical compositions of prodrugs of GABA analogs useful in treating migraine, fibromyalgia, amyotrophic lateral sclerosis, irritable bowel syndrome, social phobia, Parkinson's disease, asthma, cough, or chronic obstructive pulmonary disease are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: July 3, 2008
    Inventors: Ronald W. Barrett, Kenneth C. Cundy
  • Compounds displayed on icosahedral phage and methods of using same
    Patent number: 7229757
    Abstract: Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: June 12, 2007
    Assignee: Xenoport, Inc.
    Inventors: Ronald W. Barrett, William J. Dower, Mark Gallop, Thomas F. Woiwode, Steven E. Cwirla
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7183259
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: February 27, 2007
    Assignee: XenoPort
    Inventors: Randall A. Scheuerman, Mark A. Gallop, Kenneth C. Cundy, Ronald W. Barrett
  • Peptides and compounds that bind to a receptor
    Patent number: 7091311
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: August 15, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, David J. Duffin, Christian M. Gates, Sherril S. Haselden, Larry C. Mattheakis, Peter J. Schatz, Christopher R. Wagstrom, Nicholas C. Wrighton
  • Compounds displayed on replicable genetic packages and methods of using same
    Patent number: 7037706
    Abstract: Replicable genetic packages and collections thereof that display various compounds are provided. In some instances, the replicable genetic packages include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the replicable genetic package. The invention further provides a number of different methods for using the replicable genetic packages to screen a library of compounds for a desired biological activity.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: May 2, 2006
    Assignee: Xenoport, Inc.
    Inventors: Ronald W. Barrett, William J. Dower, Mark Gallop, Thomas F. Woiwode, Steven E. Cwirla
  • Treating or preventing hot flashes using prodrugs of GABA analogs
    Publication number: 20040254246
    Abstract: Disclosed herein are methods of using prodrugs of GABA analogs and pharmaceutical compositions thereof to treat or prevent hot flashes in humans and pharmaceutical compositions of prodrugs of GABA analogs useful in treating or preventing hot flashes.
    Type: Application
    Filed: March 31, 2004
    Publication date: December 16, 2004
    Inventors: Ronald W. Barrett, Mark A. Gallop
  • Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
    Publication number: 20040254344
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Application
    Filed: July 13, 2004
    Publication date: December 16, 2004
    Inventors: Mark Gallop, Kenneth C Cundy, Randall A Scheuerman, Ronald W Barrett, Noa Zerangue
  • Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
    Publication number: 20030216466
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Application
    Filed: May 13, 2003
    Publication date: November 20, 2003
    Inventors: Randall A. Scheuerman, Mark A. Gallop, Kenneth C. Cundy, Ronald W. Barrett
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Publication number: 20030181390
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Application
    Filed: June 12, 2002
    Publication date: September 25, 2003
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett