Patents by Inventor Ronald Zemribo

Ronald Zemribo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METABOTROPIC GLUTAMATE RECEPTOR MODULATORS
    Publication number: 20120178742
    Abstract: The invention relates to heterocyclic derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
    Type: Application
    Filed: August 3, 2010
    Publication date: July 12, 2012
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Markus Henrich, Tanja Weil, Mirko Hechenberger, Sibylle Muller, Valerjans Kauss, Ronalds Zemribo, Elina Erdmane, Gints Smits
  • Pyrazolopyrimidines for treating CNS disorders
    Publication number: 20110212956
    Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C—, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.
    Type: Application
    Filed: May 3, 2011
    Publication date: September 1, 2011
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Wojciech Danysz, Andrzej Dekundy, Mirko Hechenberger, Markus Henrich, Claudia Jatzke, Jens Nagel, Christopher Graham Raphael Parsons, Tanja Weil, Juris Fotins, Aleksandrs Gutcaitas, Ivars Kalvinsh, Ronalds Zemribo, Valerjans Kauss
  • Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators
    Patent number: 7985753
    Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C—, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: July 26, 2011
    Assignee: MERZ PHARMA GmbH & Co. KGaA
    Inventors: Wojciech Danysz, Andrzej Dekundy, Mirko Hechenberger, Markus Henrich, Claudia Jatzke, Jens Nagel, Christopher Graham Raphael Parsons, Tanja Weil, Juris Fotins, Aleksandrs Gutcaits, Ivars Kalvinsh, Ronalds Zemribo, Valerjans Kauss
  • Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators
    Patent number: 7947689
    Abstract: The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2 and Y3 independently are e.g. CR10, NH, S or O, whereby at least one of Y1, Y2 and Y3 represents CR10; R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 represent e.g. hydrogen or C1-C6-alkyl, and R10 represents e.g. hydrogen, halogen or phenyl; which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: May 24, 2011
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Wojciech Danysz, Andrzej Dekundy, Mirko Hechenberger, Markus Henrich, Claudia Jatzke, Jens Nagel, Christopher Graham Raphael Parsons, Tanja Weil, Juris Fotins, Aleksandrs Gutcaits, Ivars Kalvinsh, Ronalds Zemribo, Valerjans Kauss
  • PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE
    Publication number: 20110003820
    Abstract: The invention relates to pyrazolopyrimidine derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.
    Type: Application
    Filed: January 30, 2009
    Publication date: January 6, 2011
    Applicant: MERZ PHARMA GMBH & CO. KGaA
    Inventors: Markus Henrich, Tanja Weil, Sibylle Muller, Jens Nagel, Andreas Gravius, Valerjans Kauss, Ronalds Zemribo, Elina Erdmane
  • Pyrazolopyrimidines, a process for their preparation and their use as medicine
    Publication number: 20080039476
    Abstract: The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2 and Y3 independently are e.g. CR10, NH, S or O, whereby at least one of Y1, Y2 and Y3 represents CR10; R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 represent e.g. hydrogen or C1-C6-alkyl, and R10 represents e.g. hydrogen, halogen or phenyl; which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.
    Type: Application
    Filed: August 3, 2007
    Publication date: February 14, 2008
    Applicant: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Wojciech Danysz, Andrzej Dekundy, Mirko Hechenberger, Markus Henrich, Claudia Jatzke, Jens Nagel, Christopher Graham Raphael Parsons, Tanja Weil, Juris Fotins, Aleksandrs Gutcaits, Ivars Kalvinsh, Ronalds Zemribo, Valerjans Kauss
  • Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine
    Publication number: 20080039458
    Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C—, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.
    Type: Application
    Filed: August 3, 2007
    Publication date: February 14, 2008
    Applicant: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Wojciech Danysz, Andrzej Dekundy, Mirko Hechenberger, Markus Henrich, Claudia Jatzke, Jens Nagel, Christopher Parsons, Tanja Weil, Juris Fotins, Aleksandrs Gutcaits, Ivars Kalvinsh, Ronalds Zemribo, Valerjans Kauss
  • Pyrazolopyrimidines, a process for their preparation and their use as medicine
    Publication number: 20080032998
    Abstract: Substituted pyrazolopyrimidine derivatives of formula (I) wherein R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 independently represent e.g. hydrogen or C1-6-alkyl; R8 represents a radical R9 or a radical R10, whereby one of the two radicals R8 represents R9 and the other radical R8 represents Ret; R9 represents e.g. a phenyl or thiophene group, and R10 represents e.g. hydrogen or methyl; are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.
    Type: Application
    Filed: August 3, 2007
    Publication date: February 7, 2008
    Applicant: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Wojciech Danysz, Andrzej Dekundy, Mirko Hechenberger, Markus Henrich, Claudia Jatzke, Jens Nagel, Christopher Parsons, Tanja Weil, Juris Fotins, Aleksandrs Gutcaits, Ivars Kalvinsh, Ronalds Zemribo, Valerjans Kauss
  • Metabotropic glutamate receptor modulators
    Publication number: 20070299113
    Abstract: The invention relates to imidazothiazole derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of various disorders, including acute and/or chronic neurological disorders.
    Type: Application
    Filed: June 22, 2007
    Publication date: December 27, 2007
    Applicant: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Ivars Kalvinsh, Larisa Kaulina, Valerjans Kauss, Ronalds Zemribo, Wojciech Danysz, Markus Henrich, Christopher Graham Raphael Parsons, Tanja Weil, Elina Erdmane
  • New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1
    Publication number: 20070142386
    Abstract: There are disclosed novel compounds of formula (I) wherein A, R1, R2, R3 and X are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, atherosclerosis and pain.
    Type: Application
    Filed: October 5, 2004
    Publication date: June 21, 2007
    Applicant: AstraZeneca
    Inventors: Gunnar Nordvall, Tobias Rein, Daniel Sohn, Ronald Zemribo
  • Heterocyclic amides exhibiting and inhibitory activity at the vanilloid receptor 1(vr1)
    Publication number: 20060223868
    Abstract: Compounds of formula I, wherein R1, n, R3, R4, R7, R8 and P are as defined in the specification, salts, solvates or solvated salts thereof, processes for their preparation, new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and the use of said compounds in therapy.
    Type: Application
    Filed: April 26, 2004
    Publication date: October 5, 2006
    Applicant: AstraZeneca AB
    Inventors: Yevgeni Besidski, William Brown, Shawn Johnstone, Denis Labrecque, Alexander Munro, Didier Rotticci, Christopher Walpole, Ronald Zemribo, Andreas Petersson
  • Cyclic and acyclic propenones for treating CNS disorders
    Publication number: 20060074083
    Abstract: The invention relates to novel cyclic and non-cyclic propenone derivatives as well as their pharmaceutically acceptable slats. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are useful as medicaments.
    Type: Application
    Filed: October 5, 2005
    Publication date: April 6, 2006
    Applicant: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Ivars Kalvinsh, Valerjans Kauss, Dina Trifanova, Ronalds Zemribo, Wojciech Danysz, Markus Henrich, Christopher Parsons, Tanja Weil