Patents by Inventor Ronan C. O'Hagan

Ronan C. O'Hagan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric cancer models
    Patent number: 7622630
    Abstract: Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells into an early stage embryo, and then implanting the manipulated embryo into a surrogate mother. The ES cells contain a recombinant oncogene, and also may contain a genetic mutation that deletes or inactivates a tumor suppressor gene. Models of different types of cancer are produced by introducing different combinations of genetic mutations into the ES cells that are introduced into the early stage embryo.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: November 24, 2009
    Assignee: AVEO Pharmaceuticals, Inc.
    Inventors: Joerg Heyer, Murray Robinson, William Rideout, III, Ronald Depinho, Steven C. Clark, Yinghui Zhou, Tyler Jacks, Ronan C. O'Hagan
  • N3-Pyridyl-Thiamine And Its Use In Cancer Treatments
    Publication number: 20080234304
    Abstract: The invention provides methods using N3-pyridyl-thiamine compounds and pharmaceutical compositions comprising N3-pyridyl-thiamine, which are especially useful for preventing or reducing tumor growth in vivo. The invention is also directed to the benefits of reducing thiamine concentrations, e.g., by means of a thiamine reduced diet, as an effective step in a therapeutic regime for patients treated with N3-pyridyl-thiamine.
    Type: Application
    Filed: March 23, 2005
    Publication date: September 25, 2008
    Applicant: AVEO PHARMACEUTICALS, INC.
    Inventors: Jeno Gyuris, Ronan C. O'Hagan, May Han, Murray Robinson, Solly Weiler