Patents by Inventor Ronda Bransteitter

Ronda Bransteitter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Three-dimensional structure of the APOBEC 2 structure, uses thereof, and methods for treating chronic and infectious diseases
    Patent number: 8095350
    Abstract: Three-dimensional structure of APOBEC-2 and other structure models of APOBEC proteins obtained by computer modeling that bear similarity with a root-mean-square deviation (RMSD) of 2.0 with the APOBEC-2 monomer, dimer or tetramer. Uses of the three-dimensional structure of APOBEC-2 and models of APOBEC proteins particularly for structure-based drug design of compounds, peptides or mutant APOBEC proteins designed to treat Hyper-IgM-2 Syndrome, B cell lymphomas and lentivirus infections, particularly the human immunodeficiency virus (HIV) infection. Methods for identifying a compound that binds to any fragment of an APOBEC protein.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: January 10, 2012
    Inventors: Xiaojiang Chen, Myron Goodman, Courtney Prochnow, Ronda Bransteitter
  • Crystal structure of the catalytic domain of the viral restriction factor APOBEC3G
    Publication number: 20100081621
    Abstract: The structure, function and methods associated with proteins from the APOBEC family, which are involved in diverse biological functions, is disclosed. In one embodiment, the structure of APOBEC-3G (Apo3G) is disclosed. In another embodiment, a method of using APOBEC-3G (Apo3G) and/or Apo3G-CD2 to restrict the replication of Human Immunodeficiency Virus (HIV) and Hepatitis B virus (HBV) via cytidine deamination on ssDNA or RNA binding is disclosed. In yet another embodiment, the high-resolution crystal structure of an enzymatically active APOBEC protein, the C-terminal deaminase domain of Apo3G (Apo3G-CD2) is disclosed.
    Type: Application
    Filed: August 14, 2009
    Publication date: April 1, 2010
    Inventors: Lauren Holden, Courtney Prochnow, Y. Paul Chang, Ronda Bransteitter, Linda Chelico, Udayaditya Sen, Myron F. Goodman, Xiaojiang S. Chen
  • THREE-DIMENSIONAL STRUCTURE OF THE APOBEC 2 STRUCTURE, USES THEREOF, AND METHODS FOR TREATING CHRONIC AND INFECTIOUS DISEASES
    Publication number: 20090163422
    Abstract: Three-dimensional structure of APOBEC-2 and other structure models of APOBEC proteins obtained by computer modeling that bear similarity with a root-mean-square deviation (RMSD) of 2.0 with the APOBEC-2 monomer, dimer or tetramer. Uses of the three-dimensional structure of APOBEC-2 and models of APOBEC proteins particularly for structure-based drug design of compounds, peptides or mutant APOBEC proteins designed to treat Hyper-IgM-2 Syndrome, B cell lymphomas and lentivirus infections, particularly the human immunodeficiency virus (HIV) infection. Methods for identifying a compound that binds to any fragment of an APOBEC protein.
    Type: Application
    Filed: December 19, 2008
    Publication date: June 25, 2009
    Inventors: Xiaojiang Chen, Myron Goodman, Courtney Prochnow, Ronda Bransteitter