Abstract: A device and system for treatment of tissue by direct application thereto of therapeutic substances in the form of a stream of therapeutic droplets carried in a high velocity gas. The high velocity gas is produced by accelerating a flow of gas through at least one gas discharge nozzle. At least one flow of therapeutic substance is introduced into the high velocity gas through at least one liquid discharge nozzle, thereby fragmenting the at least one flow of therapeutic liquid into a stream of therapeutic droplets. The stream is accelerated to a velocity similar to the velocity of the gas discharge flow. The accelerated therapeutic droplet stream is then applied to a tissue for therapeutic treatment. The device and system contain a gas stream shield generator that provides a shield which prevents rebounding and dispersing droplets produced after impinging on the tissue from travelling in the direction of a user.

Abstract: Disclosed herein is a device for administering a liquid therapeutic substance to tissue, including a housing having a liquid inlet port a gas inlet port connected to a pressurized gas source; at least one therapeutic substance supply assembly mounted onto said housing, each therapeutic substance supply assembly including at least one syringe dispenser connector configured for receiving a syringe dispenser containing a predefined quantity or concentration of the liquid therapeutic substance, each syringe dispenser in fluid flow communication with one of at least one valve projecting from and external to said assembly, said syringe dispenser includes a container configured to store the liquid therapeutic substance and a piston configured to be pulled into the container as the liquid therapeutic substance is removed from said container under suction so as to flow through said at least one valve.