Patents by Inventor Rong-Chang Pai

Rong-Chang Pai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Periplasmic protein recovery
    Patent number: 4680262
    Abstract: Periplasmic proteins are recovered from transformed gram negative bacteria by a process comprising freezing and thawing the cells. Advantages are obtained by culturing the cells in phosphate-limiting media and by killing the cells prior to separation of periplasmic proteins.
    Type: Grant
    Filed: October 5, 1984
    Date of Patent: July 14, 1987
    Assignee: Genentech, Inc.
    Inventors: Barry R. Bochner, Kenneth C. Olson, Rong-Chang Pai
  • Purification and activity assurance of precipitated heterologous proteins
    Patent number: 4511503
    Abstract: A process for dissolving refractile proteins from their insoluble form by using a strongly denaturing solution.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: April 16, 1985
    Assignee: Genentech, Inc.
    Inventors: Kenneth C. Olson, Rong-Chang Pai
  • Intravenous plasma derivatives and their production
    Patent number: 4305870
    Abstract: Intravenous plasma derivatives having an acceptably lowered content of externally caused deleterious activity or exogenous activity, and their method of production are provided. The method includes the steps of mixing bentonite and an aqueous solution of plasma derivative containing exogenous activity, the bentonite and the mixing time being sufficient to adsorb exogenous activity, and isolating the aqueous phase from the bentonite. Optionally, for the removal of residual exogenous activity, the step of treatment of the aqueous phase with bentonite is repeated and/or the bentonite-treated aqueous phase is further purified by ion-exchange chromatography.
    Type: Grant
    Filed: June 13, 1980
    Date of Patent: December 15, 1981
    Assignee: Immuno Aktiengesellschaft fur chemisch-medizinische Produkte
    Inventors: Daniel T. H. Liu, Annita L. S. Weidenbach, Rong-chang Pai
  • Antihemophilic factor concentrate and its production
    Patent number: 4170639
    Abstract: Antihemophilic factor (AHF) concentrate having enhanced potency and solubility and its process of production are provided. The process includes the steps of removing unwanted protein from an aqueous extract of antihemophilic blood plasma cryoprecipitate by mixing the aqueous extract with aluminum hydroxide at an acid pH in the cold, adjusting the purified aqueous extract to an acid pH and freeze-drying the extract, optionally removing water from the extract just before freeze-drying.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: October 9, 1979
    Assignee: Warner-Lambert Company
    Inventors: Daniel T. H. Liu, John F. Irwin, Rong-Chang Pai