Patents by Inventor Rong Fu Wang

Rong Fu Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes
    Patent number: 5831016
    Abstract: The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention relates to the identification of a second tumor antigen recognized by a HLA-A31 restricted CTL clone derived from the TIL586 cell line. This antigen derived from the TRP-2 protein tumor antigen and peptides thereof are capable of sensitizing target cells for lysis by a CTL clone at 1 nM peptide concentration. Modified peptides were also recognized by the CTL clone.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: November 3, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Rong-Fu Wang, Steven A. Rosenberg