Abstract: Disclosed is a fusion protein of interleukin 2 and an application thereof in the treatment or prevention of inflammatory bowel disease, characterized in that the fusion protein comprises: human interleukin 2 or a variant thereof, and human serum albumin or a variant thereof.

Abstract: Processes for making propylene-based copolymers having broad molecular weight distributions and broad comonomer distributions using a single tubular reactor. Processes for making a propylene-based copolymer can include introducing propylene and at least one other olefin comonomer to a tubular reactor to produce a propylene-based copolymer having a broad comonomer distribution, a Mw of about 10 kg/mol to about 2.000 kg/mol, and a MWD of about 2.0 to about 10.0. The tubular reactor can include one or more heat exchanger elements, preferably a spiral heat exchanger. Propylene-based copolymer compositions can include propylene derived units and at least one other comonomer derived units, wherein the copolymer compositions have a broad comonomer distribution, a Mw of about 10 kg/mol to about 2.000 kg/mol, and a MWD of about 2.0 to about 10.0. Such compositions can have broad orthogonal comonomer distributions.

Abstract: Processes for making olefin copolymers, particularly ethylene-based copolymers. A process for making an olefin copolymer can include introducing an olefin monomer, at least one other olefin comonomer, and a single type of catalyst system to a tubular reactor to produce an olefin copolymer containing: a) an absolute comonomer distribution (CD) slope 90 of about 2.0 to about 30.0, an absolute CD slope 75 of about 2.0 to about 30.0, an absolute CD slope 50 of about 2.0 to about 30.0, or an absolute CD slope 25 of about 2.0 to about 30.0; b) a first long chain branching index (g?(Mz)) of about 0.30 to about 1.0; and c) a second long chain branching index (g?(Mz+1)) of about 0.30 to about 1.0. The tubular reactor can include one or more plug flow components, one or more spiral heat exchangers, and/or a recycle pump.

Abstract: A preparation method of a molecularly imprinted polymer (MIP) for separation and concentration of 4-methylsterane compounds is provided. A template molecule, a functional monomer, a porogen, an initiator and a cross-linking agent are mixed and subjected to polymerization to prepare a polymer with the template molecule, which is then treated to remove the template molecule, so as to give the desired MIP. The template molecule is ?-sitosterol or deoxycholic acid. The obtained molecularly imprinted polymer has multiple stable hole structures and binding sites inside, and has memory and recognition functions for the 4-methylsterane compounds, exhibiting excellent specific adsorption performance. The MIP can contribute to the accurate identification of correlation between depositional environment and maturity of crude oils or source rocks. A molecularly imprinted polymer prepared by such method, a chromatographic column and an application thereof are also provided.

Abstract: Provided are a fusion protein of interleukin 2 and application thereof in the treatment or prevention of amyotrophic lateral sclerosis (ALS).

Abstract: A preparation method of a molecularly imprinted polymer (MIP) for separation and concentration of 4-methylsterane compounds is provided. A template molecule, a functional monomer, a porogen, an initiator and a cross-linking agent are mixed and subjected to polymerization to prepare a polymer with the template molecule, which is then treated to remove the template molecule, so as to give the desired MIP. The template molecule is ?-sitosterol or deoxycholic acid. The obtained molecularly imprinted polymer has multiple stable hole structures and binding sites inside, and has memory and recognition functions for the 4-methylsterane compounds, exhibiting excellent specific adsorption performance. The MIP can contribute to the accurate identification of correlation between depositional environment and maturity of crude oils or source rocks. A molecularly imprinted polymer prepared by such method, a chromatographic column and an application thereof are also provided.

Abstract: A fusion protein of interleukin-2 and human serum albumin. By electroporating a plasmid carrying interleukin-2 and human serum albumin fusion gene into a CHO cell, a CHO monoclonal cell line stably and efficiently expressing a human recombinant protein is obtained. The monoclonal cell line can secrete and express a fusion protein of interleukin-2 and human serum albumin. The fusion protein can prolong the plasma half-life of human interleukin-2, and can be used for preparing human interleukin-2 drugs or drugs for treating various diseases such as tumors and immunodeficiency diseases.

Abstract: Disclosed are a compound-linker conjugate and a class of compounds having the STING activation activity, as well as their applications in the preparation of antibody drug conjugates. The compound-linker conjugate is represented by The compounds are represented by The compounds are suitable as payloads of the antibody drug conjugates.

Abstract: The present invention provides a display panel, a manufacturing method thereof, and a display device. The display panel includes power line layer. The power line layer includes a first power line layer and a second power line layer, and the second power line layer is electrically connected to the first power line layer. The first power line layer extends toward a first side surface of the substrate and is bent along the first side surface to a side of the substrate away from the second power line layer. A first circuit board is disposed on a side of the substrate away from the second power line layer, and the first circuit board is electrically connected to the first power line layer.

Abstract: A Pseudomonas monteilii strain with salinity-alkalinity tolerance is provided. The strain is Pseudomonas monteilii 9-2, which has been deposited in China General Microbiological Culture Collection Center (CGMCC) on Oct. 25, 2021, with an accession number of CGMCC No. 23666; and an internal transcribed spacer (ITS) sequence is shown in SEQ ID NO: 1. This application further provides an application of the Pseudomonas monteilii strain in the degradation of petroleum hydrocarbons in a saline-alkali environment.

Abstract: Provided is an Interleukin-1 Receptor Antagonist (IL-1RN) protein or a variant or analogue thereof, and a fusion protein comprising the following three-parts: the Interleukin-1 Receptor Antagonist protein or a variant or analogue thereof, a domain for half-life extension and an optional tumor necrosis factor receptor 2, and the preparation method and use thereof. The above-mentioned protein mutant and fusion protein have the effects of extended half-life, improved affinity with interleukin-1 receptor and superior biological activity, and find use in the field of treatment and prevention of inflammatory-associated diseases.

Abstract: A Pseudomonas monteilii strain with salinity-alkalinity tolerance is provided. The strain is Pseudomonas monteilii 9-2, which has been deposited in China General Microbiological Culture Collection Center (CGMCC) on Oct. 25, 2021, with an accession number of CGMCC No. 23666; and an internal transcribed spacer (ITS) sequence is shown in SEQ ID NO: 1. This application further provides an application of the Pseudomonas monteilii strain in the degradation of petroleum hydrocarbons in a saline-alkali environment.

Abstract: The present disclosure provides a composite coating and a method for fabricating the composite coating. The composite coating comprises a polymer layer, a metal interlayer and an amorphous metal coating. The polymer layer is formed on a substrate and acts as a diffusion barrier layer, which is thick and dense enough to prevent the corrosive substances from penetrating into the substrate. The metal interlayer is formed between the polymer layer and the amorphous metal coating for improving the adhesion of the amorphous metal coating to the substrate.

Abstract: The present invention provides a display panel, a manufacturing method thereof, and a display device. The display panel includes power line layer. The power line layer includes a first power line layer and a second power line layer, and the second power line layer is electrically connected to the first power line layer. The first power line layer extends toward a first side surface of the substrate and is bent along the first side surface to a side of the substrate away from the second power line layer. A first circuit board is disposed on a side of the substrate away from the second power line layer, and the first circuit board is electrically connected to the first power line layer.

Abstract: A method for analyzing light n-alkane components and carbon isotopes in deep and ultra-deep source rocks includes: (S1) subjecting a 5A molecular sieve column to aging; (S2) pyrolyzing a source rock; and allowing a pyrolysis product to enter the 5A molecular sieve column; where n-alkanes are adsorbed and retained by the 5A molecular sieve column; allowing an outflow to pass through a fractionation plate and an empty column or a weak polarity column to be discharged; and (S3) performing programmed heating such that the n-alkanes adsorbed on the 5A molecular sieve column are successively desorbed according to molecular weight, and then pass through the fractionation plate and the HP-5 or DB-5 column to enter a mass spectrometer for composition analysis or isotopic analysis. An analysis system is further provided.