Patents by Inventor Rong Ma

Rong Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250115653
    Abstract: Disclosed is a fusion protein of interleukin 2 and an application thereof in the treatment or prevention of inflammatory bowel disease, characterized in that the fusion protein comprises: human interleukin 2 or a variant thereof, and human serum albumin or a variant thereof.
    Type: Application
    Filed: July 15, 2022
    Publication date: April 10, 2025
    Inventors: Xiaorui ZHANG, Jun ZHANG, Tingting ZHAO, Jianwei CHENG, Rong MA, Yiping SUN, Xinsheng TIAN, Ziqiang LI
  • Publication number: 20250101149
    Abstract: Processes for making propylene-based copolymers having broad molecular weight distributions and broad comonomer distributions using a single tubular reactor. Processes for making a propylene-based copolymer can include introducing propylene and at least one other olefin comonomer to a tubular reactor to produce a propylene-based copolymer having a broad comonomer distribution, a Mw of about 10 kg/mol to about 2.000 kg/mol, and a MWD of about 2.0 to about 10.0. The tubular reactor can include one or more heat exchanger elements, preferably a spiral heat exchanger. Propylene-based copolymer compositions can include propylene derived units and at least one other comonomer derived units, wherein the copolymer compositions have a broad comonomer distribution, a Mw of about 10 kg/mol to about 2.000 kg/mol, and a MWD of about 2.0 to about 10.0. Such compositions can have broad orthogonal comonomer distributions.
    Type: Application
    Filed: December 14, 2022
    Publication date: March 27, 2025
    Inventors: Stacy Jordahl, Jun Shi, Rong Ma, Antonios K. Doufas, Narayanaswami Dharmarajan
  • Publication number: 20250043034
    Abstract: Processes for making olefin copolymers, particularly ethylene-based copolymers. A process for making an olefin copolymer can include introducing an olefin monomer, at least one other olefin comonomer, and a single type of catalyst system to a tubular reactor to produce an olefin copolymer containing: a) an absolute comonomer distribution (CD) slope 90 of about 2.0 to about 30.0, an absolute CD slope 75 of about 2.0 to about 30.0, an absolute CD slope 50 of about 2.0 to about 30.0, or an absolute CD slope 25 of about 2.0 to about 30.0; b) a first long chain branching index (g?(Mz)) of about 0.30 to about 1.0; and c) a second long chain branching index (g?(Mz+1)) of about 0.30 to about 1.0. The tubular reactor can include one or more plug flow components, one or more spiral heat exchangers, and/or a recycle pump.
    Type: Application
    Filed: December 14, 2022
    Publication date: February 6, 2025
    Inventors: Giriprasath Gururajan, Rong Ma, Narayanaswami Dharmarajan, Jean-Roch Schauder
  • Patent number: 12194437
    Abstract: A preparation method of a molecularly imprinted polymer (MIP) for separation and concentration of 4-methylsterane compounds is provided. A template molecule, a functional monomer, a porogen, an initiator and a cross-linking agent are mixed and subjected to polymerization to prepare a polymer with the template molecule, which is then treated to remove the template molecule, so as to give the desired MIP. The template molecule is ?-sitosterol or deoxycholic acid. The obtained molecularly imprinted polymer has multiple stable hole structures and binding sites inside, and has memory and recognition functions for the 4-methylsterane compounds, exhibiting excellent specific adsorption performance. The MIP can contribute to the accurate identification of correlation between depositional environment and maturity of crude oils or source rocks. A molecularly imprinted polymer prepared by such method, a chromatographic column and an application thereof are also provided.
    Type: Grant
    Filed: January 29, 2024
    Date of Patent: January 14, 2025
    Assignee: NORTHWEST INSTITUTE OF ECO-ENVIRONMENT AND RESOURCES, CAS
    Inventors: Yingqin Wu, Rong Ma, Yanhong Liu, Longmiao Yuan, Zhiyu Wang, Lantian Xing, Yan Liu, Yongxin Chen, Chuntao Tian
  • Publication number: 20240360192
    Abstract: Provided are a fusion protein of interleukin 2 and application thereof in the treatment or prevention of amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: July 15, 2022
    Publication date: October 31, 2024
    Inventors: Xiaorui ZHANG, Jianwei CHENG, Yang WANG, Rong MA, Yiping SUN, Xinsheng TIAN, Jun ZHANG, Ziqiang LI
  • Publication number: 20240342687
    Abstract: A preparation method of a molecularly imprinted polymer (MIP) for separation and concentration of 4-methylsterane compounds is provided. A template molecule, a functional monomer, a porogen, an initiator and a cross-linking agent are mixed and subjected to polymerization to prepare a polymer with the template molecule, which is then treated to remove the template molecule, so as to give the desired MIP. The template molecule is ?-sitosterol or deoxycholic acid. The obtained molecularly imprinted polymer has multiple stable hole structures and binding sites inside, and has memory and recognition functions for the 4-methylsterane compounds, exhibiting excellent specific adsorption performance. The MIP can contribute to the accurate identification of correlation between depositional environment and maturity of crude oils or source rocks. A molecularly imprinted polymer prepared by such method, a chromatographic column and an application thereof are also provided.
    Type: Application
    Filed: January 29, 2024
    Publication date: October 17, 2024
    Inventors: Yingqin WU, Rong MA, Yanhong LIU, Longmiao YUAN, Zhiyu WANG, Lantian XING, Yan LIU, Yongxin CHEN, Chuntao TIAN
  • Publication number: 20240287152
    Abstract: A fusion protein of interleukin-2 and human serum albumin. By electroporating a plasmid carrying interleukin-2 and human serum albumin fusion gene into a CHO cell, a CHO monoclonal cell line stably and efficiently expressing a human recombinant protein is obtained. The monoclonal cell line can secrete and express a fusion protein of interleukin-2 and human serum albumin. The fusion protein can prolong the plasma half-life of human interleukin-2, and can be used for preparing human interleukin-2 drugs or drugs for treating various diseases such as tumors and immunodeficiency diseases.
    Type: Application
    Filed: September 29, 2021
    Publication date: August 29, 2024
    Inventors: Ziqiang LI, Xinsheng TIAN, Jianwei CHENG, Rong MA, Yanjing JIANG, Yiping SUN, Xiaorui ZHANG, Tingting ZHAO, Jun ZHANG
  • Publication number: 20240269305
    Abstract: Disclosed are a compound-linker conjugate and a class of compounds having the STING activation activity, as well as their applications in the preparation of antibody drug conjugates. The compound-linker conjugate is represented by The compounds are represented by The compounds are suitable as payloads of the antibody drug conjugates.
    Type: Application
    Filed: February 24, 2024
    Publication date: August 15, 2024
    Inventors: Jin LI, Fei PAN, Rong MA, Sen GAO, Rongfeng WU, Xiaoguang BAI
  • Patent number: 11971636
    Abstract: The present invention provides a display panel, a manufacturing method thereof, and a display device. The display panel includes power line layer. The power line layer includes a first power line layer and a second power line layer, and the second power line layer is electrically connected to the first power line layer. The first power line layer extends toward a first side surface of the substrate and is bent along the first side surface to a side of the substrate away from the second power line layer. A first circuit board is disposed on a side of the substrate away from the second power line layer, and the first circuit board is electrically connected to the first power line layer.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: April 30, 2024
    Assignee: Wuhan China Star Optoelectronics Technology Co., Ltd.
    Inventor: Rong Ma
  • Patent number: 11959066
    Abstract: A Pseudomonas monteilii strain with salinity-alkalinity tolerance is provided. The strain is Pseudomonas monteilii 9-2, which has been deposited in China General Microbiological Culture Collection Center (CGMCC) on Oct. 25, 2021, with an accession number of CGMCC No. 23666; and an internal transcribed spacer (ITS) sequence is shown in SEQ ID NO: 1. This application further provides an application of the Pseudomonas monteilii strain in the degradation of petroleum hydrocarbons in a saline-alkali environment.
    Type: Grant
    Filed: January 4, 2023
    Date of Patent: April 16, 2024
    Assignee: Northwest Institute of Eco-Environment and Resources, CAS
    Inventors: Yingqin Wu, Zhiyu Wang, Tong Wang, Longmiao Yuan, Yanhong Liu, Rong Ma
  • Publication number: 20240018206
    Abstract: Provided is an Interleukin-1 Receptor Antagonist (IL-1RN) protein or a variant or analogue thereof, and a fusion protein comprising the following three-parts: the Interleukin-1 Receptor Antagonist protein or a variant or analogue thereof, a domain for half-life extension and an optional tumor necrosis factor receptor 2, and the preparation method and use thereof. The above-mentioned protein mutant and fusion protein have the effects of extended half-life, improved affinity with interleukin-1 receptor and superior biological activity, and find use in the field of treatment and prevention of inflammatory-associated diseases.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 18, 2024
    Inventors: Ziqiang LI, Rong MA, Xinsheng TIAN, Yiping SUN, Yiren LIU, Shaokui LI
  • Publication number: 20230365917
    Abstract: A Pseudomonas monteilii strain with salinity-alkalinity tolerance is provided. The strain is Pseudomonas monteilii 9-2, which has been deposited in China General Microbiological Culture Collection Center (CGMCC) on Oct. 25, 2021, with an accession number of CGMCC No. 23666; and an internal transcribed spacer (ITS) sequence is shown in SEQ ID NO: 1. This application further provides an application of the Pseudomonas monteilii strain in the degradation of petroleum hydrocarbons in a saline-alkali environment.
    Type: Application
    Filed: January 4, 2023
    Publication date: November 16, 2023
    Inventors: Yingqin WU, Zhiyu WANG, Tong WANG, Longmiao YUAN, Yanhong LIU, Rong MA
  • Patent number: 11814542
    Abstract: The present disclosure provides a composite coating and a method for fabricating the composite coating. The composite coating comprises a polymer layer, a metal interlayer and an amorphous metal coating. The polymer layer is formed on a substrate and acts as a diffusion barrier layer, which is thick and dense enough to prevent the corrosive substances from penetrating into the substrate. The metal interlayer is formed between the polymer layer and the amorphous metal coating for improving the adhesion of the amorphous metal coating to the substrate.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: November 14, 2023
    Assignee: Nano and Advanced Materials Institute Limited
    Inventors: Song Wang, Weizhen Wang, Rong Ma
  • Publication number: 20230176432
    Abstract: The present invention provides a display panel, a manufacturing method thereof, and a display device. The display panel includes power line layer. The power line layer includes a first power line layer and a second power line layer, and the second power line layer is electrically connected to the first power line layer. The first power line layer extends toward a first side surface of the substrate and is bent along the first side surface to a side of the substrate away from the second power line layer. A first circuit board is disposed on a side of the substrate away from the second power line layer, and the first circuit board is electrically connected to the first power line layer.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 8, 2023
    Applicant: Wuhan China Star Optoelectronics Technology Co., Ltd.
    Inventor: Rong MA
  • Publication number: 20230152285
    Abstract: A method for analyzing light n-alkane components and carbon isotopes in deep and ultra-deep source rocks includes: (S1) subjecting a 5A molecular sieve column to aging; (S2) pyrolyzing a source rock; and allowing a pyrolysis product to enter the 5A molecular sieve column; where n-alkanes are adsorbed and retained by the 5A molecular sieve column; allowing an outflow to pass through a fractionation plate and an empty column or a weak polarity column to be discharged; and (S3) performing programmed heating such that the n-alkanes adsorbed on the 5A molecular sieve column are successively desorbed according to molecular weight, and then pass through the fractionation plate and the HP-5 or DB-5 column to enter a mass spectrometer for composition analysis or isotopic analysis. An analysis system is further provided.
    Type: Application
    Filed: November 4, 2022
    Publication date: May 18, 2023
    Inventors: Yingqin WU, Tong WANG, Zhiyu WANG, Rong MA, Yan LIU, Zuodong WANG
  • Patent number: D997381
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: August 29, 2023
    Assignee: Zhejiang Orient Gene Biotech Co., Ltd
    Inventors: Shaohua Fang, Gang Li, Jianqiu Fang, Hongjiang Yu, Xuguang Zeng, Rong Ma
  • Patent number: D1003738
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: November 7, 2023
    Assignee: ZHEJIANG ORIENT GENE BIOTECH CO., LTD
    Inventors: Rong Ma, Shaohua Fang, Hongjiang Yu, Gang Li, Jianqiu Fang, Yating Lu
  • Patent number: D1021239
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: April 2, 2024
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Qiu Rong Ma, Yi Mu Yang, Ling-Yuan Liou
  • Patent number: D1028278
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: May 21, 2024
    Assignee: ZHEJIANG ORIENT GENE BIOTECH CO., LTD.
    Inventors: Shaohua Fang, Siyu Lei, Jianqiu Fang, Rong Ma
  • Patent number: D1038523
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: August 6, 2024
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Qiu Rong Ma, Yi Mu Yang