Abstract: The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.

Abstract: Provided herein are polymers, pH-sensitive polymers and/or linkers; conjugates comprising said polymers and/or linkers, optionally, coupled to one or more agents and/or targeting moieties; and particles (e.g., nanoparticles comprising the aforesaid polymers, linkers and/or conjugates), which can be used to enhance the delivery and/or efficacy of one or more agents in a subject.

Abstract: Provided herein are polymers, pH-sensitive polymers and/or linkers; conjugates comprising said polymers and/or linkers, optionally, coupled to one or more agents and/or targeting moieties; and particles (e.g., nanoparticles comprising the aforesaid polymers, linkers and/or conjugates), which can be used to enhance the delivery and/or efficacy of one or more agents in a subject.

Abstract: Methods for efficient preparation of drug-polymer (or oligomer) conjugates useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications are provided. The invention also provides nanoparticles prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.

Abstract: The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.

Abstract: The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.

Abstract: Methods for efficient preparation of drug-polymer (or oligomer) conjugates useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications are provided. The invention also provides nanoparticles prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.

Abstract: The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

Abstract: A method for executing a fully mixed initiative dialogue (FMID) interaction between a human and a machine, a dialogue system for a FMID interaction between a human and a machine and a computer readable data storage medium having stored thereon computer code for instructing a computer processor to execute a method for executing a FMID interaction between a human and a machine are provided. The method includes retrieving a predefined grammar setting out parameters for the interaction; receiving a voice input; analyzing the grammar to dynamically derive one or more semantic combinations based on the parameters; obtaining semantic content by performing voice recognition on the voice input; and assigning the semantic content as fulfilling the one or more semantic combinations.

Abstract: The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.

Abstract: A noise processing device and its method are provided for a video/audio system having a high definition multimedia interface (HDMI). The noise processing device includes a detecting unit, a signal generating unit, and a decision unit. The noise processing method includes using the detecting unit to monitor a variation related to an audio signal and generate a detecting signal accordingly; using the signal generating unit to produce an adjustment signal according to the detecting signal; and using the decision unit to produce an output audio signal according to the audio signal and the adjustment signal. Another embodiment of the noise processing device includes a compensation tracking unit having a control unit. The compensation tracking unit produces an output audio signal according to a difference between the output audio signal itself and the audio signal and a gain of the control unit.

Abstract: The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.

Abstract: A method for executing a fully mixed initiative dialogue (FMID) interaction between a human and a machine, a dialogue system for a FMID interaction between a human and a machine and a computer readable data storage medium having stored thereon computer code for instructing a computer processor to execute a method for executing a FMID interaction between a human and a machine are provided. The method includes retrieving a predefined grammar setting out parameters for the interaction; receiving a voice input; analysing the grammar to dynamically derive one or more semantic combinations based on the parameters; obtaining semantic content by performing voice recognition on the voice input; and assigning the semantic content as fulfilling the one or more semantic combinations.

Abstract: A method for converting a frame rate of a video signal comprising a data enable signal by means of a first buffer and a second buffer is disclosed. The method comprises: alternatively accessing the first buffer and the second buffer according to a first frame rate; determining an accessing time point of the first and the second buffers according to the data enable signal; and accessing the buffer, which is one of the first and the second buffers and not accessed at the accessing time point, according to a second frame rate, wherein the second frame rate is faster than the first frame rate.

Abstract: Methods for efficient preparation of drug-polymer (or oligomer) conjugates which are useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications. The invention additionally provides certain drug-polymer and drug-oligomer conjugates which are useful in the preparation of particles for delivery of the drug in vivo. The invention also provides nanoparticles of this invention prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug).

Abstract: A phase frequency detector includes a phase error detector outputting a phase error signal according to a first input signal and a second input signal; a phase error judgment unit outputting a phase error judgment signal according to the first input signal and the second input signal; and a reset unit outputting a first reset signal to reset the phase error detector, and outputting a second reset signal to reset the phase error judgment unit, according to the phase error judgment signal.

Abstract: A chip with an adjustable pinout function is disclosed. The chip includes a first pinout, a second pinout, a logic circuit, and a selecting circuit. The logic circuit includes a first port and a second port. The selecting circuit, which is coupled to the logic circuit, the first pinout, and the second pinout, controls the first pinout to be coupled to the first port or the second port, and controls the second pinout to be coupled to the first port or the second port.

Abstract: A data recovery system and method is disclosed, which comprises an oversampler, a phase detection circuit, a data pick circuit, a data overlap/skip detection circuit and a data correction circuit. The oversampler oversamples an input signal and thus generates oversampled signals. The phase detection circuit receives for detecting transitions of the oversampled signals and outputting a phase signal. The data pick circuit receives the phase signal, accordingly groups the oversampled signals into n groups and picks one group as an output data. The data overlap/skip detection circuit determines if data is overlapped or skipped according to the phase signal and the last phase signal. The data correction circuit corrects data when data is overlapped or skipped and outputs an accurate output data.

Abstract: A noise processing device and its method are provided for a video/audio system having a high definition multimedia interface (HDMI). The noise processing device includes a detecting unit, a signal generating unit, and a decision unit. The noise processing method includes using the detecting unit to monitor a variation related to an audio signal and generate a detecting signal accordingly; using the signal generating unit to produce an adjustment signal according to the detecting signal; and using the decision unit to produce an output audio signal according to the audio signal and the adjustment signal. Another embodiment of the noise processing device includes a compensation tracking unit having a control unit. The compensation tracking unit produces an output audio signal according to a difference between the output audio signal itself and the audio signal and a gain of the control unit.

Abstract: A chip with an adjustable pinout function is disclosed. The chip includes a first pinout, a second pinout, a logic circuit, and a selecting circuit. The logic circuit includes a first port and a second port. The selecting circuit, which is coupled to the logic circuit, the first pinout, and the second pinout, controls the first pinout to be coupled to the first port or the second port, and controls the second pinout to be coupled to the first port or the second port.