Patents by Inventor Rong-Tsun Wu

Rong-Tsun Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080044495
    Abstract: An extract of plant Dendrobii Caulis and preparing process thereof are provided. A physiologically active extract of a plant Dendrobii Caulis and the method thereof are provided in the present invention. The extract is obtained by an extraction of the plant or parts thereof with a water miscible organic solvent or a mixture thereof with water.
    Type: Application
    Filed: September 30, 2005
    Publication date: February 21, 2008
    Inventor: Rong-Tsun Wu
  • Publication number: 20080008775
    Abstract: The present invention provides a method for treating diabetic vascular complications including administering to a subject in need thereof a therapeutically effective amount of an extract product of a Dioscorea species. The extract product preferably is prepared by a process which involves (a) extracting a tuber of the Dioscorea species with an alcohol-based solvent in the presence of an acetic acid solution to form an extract composition, (b) subjecting a resultant product obtained in step (a) to obtain a soluble fraction, and (c) removing solvent from the soluble fraction obtained in step (b) to obtain the extract product.
    Type: Application
    Filed: October 18, 2006
    Publication date: January 10, 2008
    Inventor: Rong-Tsun Wu
  • Publication number: 20060251739
    Abstract: The present invention provides the composition and the method for treating autoimmune diseases and a mucosal disorder via oral-tolerance induction and innate immunity promotion. The composition for treating the autoimmune disease and mucosal disorder includes the polysaccharide prepared from a plant, wherein the plant belongs to Genus Dendrobium.
    Type: Application
    Filed: May 4, 2005
    Publication date: November 9, 2006
    Applicant: National Yang-Ming University
    Inventor: Rong-Tsun Wu
  • Patent number: 7101577
    Abstract: An extract of plant Dendrobii Caulis and preparing process thereof are provided. A physiologically active extract of a plant Dendrobii Caulis and the method thereof are provided in the present invention. The extract is obtained by an extraction of the plant or parts thereof with a water miscible organic solvent or a mixture thereof with water.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: September 5, 2006
    Assignee: National Yang-Ming University
    Inventor: Rong-Tsun Wu
  • Publication number: 20060068036
    Abstract: The present invention provides a method for treating osteoporosis in a subject in need of such treatment, including administering orally to the subject an effective amount of an extract product of a Dioscorea species capable of promoting proliferation and differentiation of bone marrow cells in the subject, wherein the Dioscorea species is characterized by a randomly amplified polymorphic DNA (RAPD) fingerprint including 14 DNA bands ranging from 428 bp, 452 bp, 537 bp, 602 bp, 723 bp, 817 bp, 934 bp, 1140 bp, 1242 bp, 1478 bp, 1641 bp, 1904 bp, 2151 bp and 2918 bp, respectively, when genomic DNA of the Dioscorea species is amplified with a primer of SEQ ID NO: 9, and the extract product is prepared by a process including the steps of: (a) extracting a tuber of the Dioscorea species using an alcohol-based solvent in the presence of acetic acid; (b) subjecting the resultant product obtained in step (a) to a separating treatment to obtain a soluble fraction; and (c) removing solvent from the soluble fraction ob
    Type: Application
    Filed: November 15, 2005
    Publication date: March 30, 2006
    Inventor: Rong-Tsun Wu
  • Patent number: 6998262
    Abstract: This invention provides a Dioscorea polysaccharide extract prepared by the method of this invention, which enhances the immunological activities by regulating the gene expression of cytokines. This invention further provides a Dioscorea polysaccharide extract, which has a synergistic effect with an oral vaccine and is capable of eliminating oral tolerance.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: February 14, 2006
    Assignee: National Yang-Ming University
    Inventor: Rong-Tsun Wu
  • Publication number: 20050196479
    Abstract: This invention provides a Dioscorea polysaccharide extract prepared by the method of this invention, which enhances the immunological activities by regulating the gene expression of cytokines. This invention further provides a Dioscorea polysaccharide extract, which has a synergistic effect with an oral vaccine and is capable of eliminating oral tolerance.
    Type: Application
    Filed: March 29, 2005
    Publication date: September 8, 2005
    Inventor: Rong-Tsun Wu
  • Publication number: 20050048137
    Abstract: An extract of plant Dendrobii Caulis and preparing process thereof are provided. A physiologically active extract of a plant Dendrobii Caulis and the method thereof are provided in the present invention. The extract is obtained by an extraction of the plant or parts thereof with a water miscible organic solvent or a mixture thereof with water.
    Type: Application
    Filed: August 25, 2003
    Publication date: March 3, 2005
    Inventor: Rong-Tsun Wu
  • Publication number: 20050042314
    Abstract: Disclosed herein are processes for preparing extract products from the root of Polygonum multiflorum Thunb. and the extract products thus obtained, which are biologically active in promoting the proliferation, growth and/or differentiation of hematocytes and bone marrow cells in vitro and in vivo.
    Type: Application
    Filed: August 22, 2003
    Publication date: February 24, 2005
    Inventor: Rong-Tsun Wu
  • Publication number: 20040126447
    Abstract: The present invention provides extract fractions of Dioscorea sp. prepared by the method according to the present invention, which enhance the proliferation and differentiation of bone marrow cells, and provides a method for treatment of osteoporosis and a method for alleviation of side effects caused by chemotherapy.
    Type: Application
    Filed: December 31, 2002
    Publication date: July 1, 2004
    Inventor: Rong-Tsun Wu
  • Publication number: 20030224066
    Abstract: This invention provides a Dioscorea polysaccharide extract prepared by the method of this invention, which enhances the immunological activities by regulating the gene expression of cytokines. This invention further provides a Dioscorea polysaccharide extract, which has a synergistic effect with an oral vaccine and is capable of eliminating oral tolerance.
    Type: Application
    Filed: May 30, 2002
    Publication date: December 4, 2003
    Inventor: Rong-Tsun Wu
  • Patent number: 6613754
    Abstract: In a process for preparing a polysaccharide-based extract, raw material of ganoderma genus is subjected to an alcohol treatment to obtain a polysaccharide-rich product from which a supernatant solution is subsequently obtained with the use of water of an elevated temperature as an extracting agent. Thereafter, alcohol is added to the supernatant solution to precipitate the polysaccharide-based extract. The polysaccharide-based extract can be used in an orally active medicinal product which has immunopotentiating and antitumoral effects.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: September 2, 2003
    Assignee: National Yang-Ming University
    Inventor: Rong-Tsun Wu
  • Patent number: 5753692
    Abstract: A method of augmenting the immune system including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH.dbd.NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 .dbd.CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently, is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 19, 1998
    Assignee: Industrial Technology Research Institute
    Inventors: Ching-Te Chang, Kuo-Mou Chen, Wann-Huang Liu, Fen-Lan Lin, Rong-Tsun Wu
  • Patent number: 5747525
    Abstract: A method of treating tumor including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH.dbd.NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 .dbd.CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently, is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 5, 1998
    Assignee: Industrial Technology Research Institute
    Inventors: Ching-Te Chang, Kuo-Mou Chen, Wann-Huang Liu, Fen-Lan Lin, Rong-Tsun Wu
  • Patent number: 5602170
    Abstract: A method of treating inflammation including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH=NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 =CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.
    Type: Grant
    Filed: September 8, 1994
    Date of Patent: February 11, 1997
    Assignee: Industrial Technology Research Institute
    Inventors: Ching-Te Chang, Kuo-Mou Chen, Wann-Huang Liu, Fen-Lan Lin, Rong-Tsun Wu
  • Patent number: 5596014
    Abstract: A pharmaceutical composition containing a compound and an excipient, the compound having the formula: ##STR1## in which n is 2, 3 or 4; R is H, --CH(R.sup.1).cndot.OR.sup.2, --CH(O--Z).sub.2, or --COR.sup.3 ; R.sup.1 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, OH, C.sub.1-6 hydroxyalkyl, or COOH; R.sup.2 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, tetrahydropyranyl, phenyl, benzoyl, C.sub.1-6 acyl, tosyl, or --CO--Y--COOH; and R.sup.3 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, OH, C.sub.1-6 hydroxyalkyl, or COOH; wherein Z is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.1-6 acyl; and Y is C.sub.1-6 alkylidene, C.sub.2-6 alkenylidene, phenylene, or deleted; or an ester or a salt thereof.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 21, 1997
    Assignee: Industrial Technology Research Institute
    Inventors: Ching-Te Chang, Rong-Tsun Wu