Patents by Inventor Rong Yang

Rong Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10239850
    Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: March 26, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Charles N. Serhan, Rong Yang
  • Patent number: 10233168
    Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: March 19, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Charles N. Serhan, Rong Yang
  • Patent number: 10233167
    Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: March 19, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Charles N. Serhan, Rong Yang
  • Patent number: 10227291
    Abstract: The invention describes novel mono or dihydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: March 12, 2019
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Charles N. Serhan, Rong Yang
  • Publication number: 20190030179
    Abstract: A method of producing synergistic and enhanced efficacy in treating a disease in a subject includes providing an antibody, the antibody being a classic antibody or a modified biologic molecule that blocks a first target in the subject; providing a drug, the drug being a small molecule agent that blocks the first target or a second target in the subject; connecting the antibody and the drug with a linker to form an Antibody-Drug Synergism (ADS) compound; and treating the disease with the ADS compound. The linker is hydrolyzed in the subject over a certain time so that both the antibody and the drug exert their functions simultaneously, and the ADS compound confers better efficacy than either the antibody or the drug alone due to a synergism of the ADS compound.
    Type: Application
    Filed: February 2, 2017
    Publication date: January 31, 2019
    Inventors: Jinsong NI, Rong YANG
  • Publication number: 20190029553
    Abstract: An ECG system measures and annotates a subdivision of the P wave of the ECG waveform from harmonic waveforms. Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients. Starting and ending discontinuity points are identified for a subdivision of the P wave of the ECG waveform and an APD is calculated for the subdivision. The ECG waveform is displayed along with a location of the P wave subdivision on the ECG waveform and the calculated APD.
    Type: Application
    Filed: August 16, 2018
    Publication date: January 31, 2019
    Inventors: Guangren Chen, Rong Yang
  • Publication number: 20190015409
    Abstract: Compositions and methods of using nintedanib for improving the success rate of glaucoma filtration surgery are disclosed herein. Nintedanib can be used alone or in combination with an anti-metabolite drug in a topical or implant eye formulation.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 17, 2019
    Inventors: Jinsong Ni, Rong Yang
  • Publication number: 20190015006
    Abstract: An ECG system measures and annotates the P-point of an ECG waveform from harmonic waveforms. Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients. A discontinuity point is identified as the P-point of the ECG waveform from the comparison. Similar measurements are made for the P?-point, I-point, J-point, and T?-point. Distances from these points to the equipotential line are calculated and used to detect blockages leading to myocardial infarction.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 17, 2019
    Inventors: Guangren Chen, Rong Yang
  • Patent number: 10123988
    Abstract: The present invention provides topical dermal compositions including microsphere encapsulated isotretinoin. Pharmaceutically acceptable salts, esters, or amides of isotretinoin are also contemplated for use in the practice of the invention. The compositions of the invention are useful for treating a variety of conditions associated with excess sebum production, such as, for example, acne.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 13, 2018
    Assignee: Allergan, Inc.
    Inventors: John E. Donello, Rong Yang
  • Publication number: 20180319665
    Abstract: The present invention relates to carbon nanotubes and a preparation method thereof by using PET. The carbon nanotubes of the present invention are prepared by processes of alcoholysis of PET materials, processes of washing, crushing and calcining unreacted intermediates and so on. By the preparation method of the present invention, multi-walled carbon nanotubes prepared by using waste PET have a good conductivity, and are a structure of top-down array with low aspect ratio. The method of the present invention is not only easy to implement, but also does not need a catalyst, and turns the waste PET into treasure, which solves the problem of environmental pollution caused by the increasingly serious waste PET. FIG. 9.
    Type: Application
    Filed: April 19, 2018
    Publication date: November 8, 2018
    Inventors: Changqing Fang, Xing Zhou, Rong Yang, Shaofei Pan, Wanqing Lei, Yan Li
  • Patent number: 10117635
    Abstract: A noninvasive system for detecting and processing PCG and ECG waveforms includes an electronic acoustic stethoscope and a server computer. Heart sounds of a patient are measured using an acoustic transducer of a chestpiece of the electronic acoustic stethoscope, the heart sounds are sent to an earpiece of the electronic acoustic stethoscope, and a PCG waveform is created. Heart electrical signals of the patient are measured using at least four electrodes of the chestpiece and an ECG waveform is created. The PCG waveform and/or the ECG waveform are transmitted to the server computer using a wireless communication device of the chestpiece. The PCG waveform is processed for additional PCG information and/or the ECG waveform is processed for additional ECG information using the server computer. Access to the additional PCG information and/or additional ECG information is provided to at least one client device using the server computer.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: November 6, 2018
    Inventors: Guangren Chen, Rong Yang
  • Patent number: 10092201
    Abstract: An ECG system measures and annotates the I-point of in an ECG waveform from harmonic waveforms. Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients. A discontinuity point is identified as the I-point of the ECG waveform from the comparison. The ECG waveform is displayed along with a marker at a location of the discontinuity point.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: October 9, 2018
    Inventors: Guangren Chen, Rong Yang, Zhongnong Jiang
  • Patent number: 10096505
    Abstract: A wafer cassette includes a case, a plurality of wafer trays, and a plurality of transmission mechanisms. The wafer trays are disposed in the case. Each of the wafer trays includes a central opening, a first groove, and a second groove. The diameter of the second groove is greater than that of the first groove. A bottom surface of the second groove is higher than that of the first groove. The first and second grooves surround the central opening. Each of the transmission mechanisms is connected to the corresponding wafer tray to move the wafer tray between a pick-up position and a received position. Since the wafer tray has grooves with different diameters, the wafer tray is capable of receiving wafers with different sizes.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: October 9, 2018
    Assignee: MPI CORPORATION
    Inventors: Lin-Lin Chih, Chien-Hung Chen, Cheng-Rong Yang, Stojan Kanev
  • Publication number: 20180287473
    Abstract: A reluctance motor has salient teeth on both the stator and the rotor. The reluctance motor includes electrical coils that are usable to generate magnetic flux to drive rotation of the rotor. Concentrated coil windings are wound around each stator tooth. The electrical coils are arranged across all the stator teeth of the reluctance motor to enable the reluctance motor to be driven by alternating current. The electrical coils are arranged so that, when excited with alternating current, the number of magnetic half-poles is equal to the number of teeth on the rotor. The reluctance machine can operate using an inverter instead of an asymmetric bridge.
    Type: Application
    Filed: March 28, 2018
    Publication date: October 4, 2018
    Inventors: Berker Bilgin, Rong Yang, Nigel Schofield, Ali Emadi
  • Patent number: 10085663
    Abstract: An ECG system identifies and annotates cardiac electrophysiological signals in an ECG waveform from harmonic waveforms. Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients. At least one subwaveform or one or more discontinuity points are identified as a normal or abnormal electrophysiological signal of the ECG waveform from the comparison. The ECG waveform is displayed along with one or more markers at a location of the at least one subwaveform or one or more discontinuity points.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: October 2, 2018
    Inventors: Guangren Chen, Rong Yang, Zhongnong Jiang
  • Patent number: 10072583
    Abstract: A mounting bracket for mounting an accessory to a gas turbine engine, the mounting bracket including a space frame structure. The space frame structure including a plurality of struts joined to one another at nodes.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: September 11, 2018
    Assignee: ROLLS-ROYCE plc
    Inventors: Richard Peace, Rong Yang, Joshua Lee, Liam Kelly
  • Publication number: 20180235497
    Abstract: An ECG system measures and annotates the I-point of in an ECG waveform from harmonic waveforms. Electrical impulses are received from a beating heart. The electrical impulses are converted to an ECG waveform. The ECG waveform is converted to a frequency domain waveform, which, in turn, is separated into two or more different frequency domain waveforms, which, in turn, are converted into a plurality of time domain cardiac electrophysiological subwaveforms and discontinuity points between these subwaveforms. The plurality of subwaveforms and discontinuity points are compared to a database of subwaveforms and discontinuity points for normal and abnormal patients. A discontinuity point is identified as the I-point of the ECG waveform from the comparison. The ECG waveform is displayed along with a marker at a location of the discontinuity point.
    Type: Application
    Filed: April 25, 2018
    Publication date: August 23, 2018
    Inventors: Guangren Chen, Rong Yang, Zhongnong Jiang
  • Patent number: 10053307
    Abstract: A shuttle van system for a container terminal, including: at least one rail and a transfer device. The transfer device includes a plurality of shuttle vans and a plurality of transition platforms. Each shuttle van includes: a base frame, a wheel group, a wheel driving device, a lifting device, and a supporting plate. Each transition platform includes brackets. The shuttle vans run on the rail between the brackets. The lifting device of the shuttle van is configured to lift the container from the supporting plate. The container is transferred from the supporting plate of the shuttle van to the bracket after contraction of the lifting device.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: August 21, 2018
    Assignee: TIANJIN PORT (GROUP) CO., LTD.
    Inventors: Wei Li, Xun Li, Guoli An, Lianyi Zhu, Qingxin Lv, Rong Yang, Qiang Li
  • Publication number: 20180228903
    Abstract: The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 16, 2018
    Applicants: Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Daniel S. Kohane, Rong Yang, Lily Yun Lin
  • Publication number: 20180191856
    Abstract: A proxy connected to a terminal device in a public network and to two servers in a private network is provided. The first server has a first domain name identifiable in the private network and a predetermined domain name identifiable in the public network, and the second server has a second domain name identifiable in the private network. When receiving an access request from the terminal device, which was sent from the predetermined domain name to the second domain name, the proxy replaces the predetermined domain name with the first domain name and forwards the access request to the second server. When receiving an access response from the second server, which was sent from the second domain name to the first domain name, the proxy replaces the first domain name with the predetermined domain name and forwards the access response to the terminal device.
    Type: Application
    Filed: October 31, 2017
    Publication date: July 5, 2018
    Inventors: Jen-Yao CHANG, Zuo-Rong YANG