Patents by Inventor Rongde Cheng

Rongde Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing aliskiren and its intermediates thereof
    Patent number: 8664440
    Abstract: A method for preparing Aliskiren and intermediate thereof, which comprises the following steps: reacting 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with magnesium isopropyl chloride and n-BuLi to obtain the compound of formula XXII; reacting the product of methylsulfonylation of the compound of formula XIX with anhydrous LiBr to obtain the compound of formula XXI; obtaining the intermediate of Aliskiren shown as formula XV by reacting the compound of formula XXII with the compound of formula XXI in an ether as the solvent and in the presence of a catalyst containing iron; then reacting the compound of formula XV with the compound of formula VII to obtain the compound of formula XXIII, following removing R1 from the amino group and obtaining Aliskiren shown as formula I.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: March 4, 2014
    Assignee: Zhejiang Tianyu Pharmaceutical Co., Ltd
    Inventors: Yongjun Tu, Yi Zhang, Rongde Cheng, Lingchao Peng
  • METHOD FOR PREPARING ALISKIREN AND ITS INTERMEDIATES THEREOF
    Publication number: 20130225841
    Abstract: A method for preparing Aliskiren and intermediate thereof, which comprises the following steps: reacting 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with magnesium isopropyl chloride and n-BuLi to obtain the compound of formula XXII; reacting the product of methylsulfonylation of the compound of formula XIX with anhydrous LiBr to obtain the compound of formula XXI; obtaining the intermediate of Aliskiren shown as formula XV by reacting the compound of formula XXII with the compound of formula XXI in an ether as the solvent and in the presence of a catalyst containing iron; then reacting the compound of formula XV with the compound of formula VII to obtain the compound of formula XXIII, following removing R1 from the amino group and obtaining Aliskiren shown as formula I.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 29, 2013
    Applicant: Zhejiang Tianyu Pharmaceutical Co., Ltd.
    Inventors: Yongjun Tu, Yi Zhang, Rongde Cheng, Lingchao Peng