Abstract: The present disclosure provides an isolated recombinant oncolytic adenovirus, a pharmaceutical composition, and uses thereof for drugs for treatment of tumors and/or cancers. The recombinant oncolytic adenovirus is a selectively replicating oncolytic adenovirus, and the genome of the recombinant oncolytic adenovirus is integrated with a coding sequence of exogenous shRNA capable of inhibiting PDL1 expression in tumor cells. The replication capability of the virus in normal primary cells is much lower than the replication capability of the virus in tumor cells. Moreover, the expressed shPDL1 can significantly reduce the level of PDL1 protein highly expressed in tumor cells. Thus, the oncolytic killing effect of the oncolytic virus and the anti-tumor immunostimulatory effect of immune cells produce a synergistic effect.

Abstract: A method for analyzing a sever accident in a nuclear reactor based on an advanced particle method includes steps of: 1) performing geometric modeling, setting initial conditions and boundary conditions; 2) updating material physical properties and key parameters; 3) performing mechanical structure module calculation, updating solid particle stress, strain, internal energy, displacement and velocity; 4) performing thermal hydraulic module calculation, updating fluid particle internal energy, position and velocity; 5) performing chemical reaction module calculation, updating particle matter composition and internal energy; 6) performing neutron physics module calculation, updating particle neutron flux density; and 7) outputting data. The method of the present invention is based on the discrete form of the advanced particle method, which is capable of accurately capturing cross-sectional changes, matter changes, and phase changes.

Abstract: The present disclosure discloses a wind-solar reactor system and a working method thereof. The wind-solar reactor system comprises a nuclear reactor system, a wind power generation system, a solar power storage system and a balance energy system, wherein the nuclear reactor system uses an integrated small modular reactor design, the solar power storage system uses a tower-type solar power storage system design, and a hydrogen production system uses a copper-chlorine cycle hydrogen production technology. A reactor keeps rated full-power operation, generated electricity is adjusted and distributed through a power controller, most of the electricity is used for smoothing the fluctuation of wind power generation, and the excess electricity is used for hydrogen storage of the hydrogen system. Solar power is used for heating saturated steam generated by the reactor into superheated steam through a heater, and then the superheated steam enters a high-pressure cylinder to do work by expansion.

Abstract: The invention discloses a battery covering structure with replaceable terminals, comprising a covering and terminals, the terminals are located on the covering, and the covering is used for connecting with the battery body, the terminals are detachably connected with the covering. The invention makes the replacement of terminals convenient and quick, which enables the structure to be matched with various types of automobiles and motorcycles, and is beneficial to improving the applicability of battery.

Abstract: Described herein are textured glass-based articles. The textured glass based articles may include a glass-based substrate including a first major surface and a second major surface. At least a portion of one or both of the first major surface and the second major surface is textured, wherein the portion of the one or both of the first major surface and the second major surface that are textured may have a sparkle at 140 ppi of less than or equal to 5% and an uncoupled distinctness-of-image of at least 78%. Methods for making such articles are also described herein.

Abstract: Methods and systems are described for image segmentation. A machine learning model is applied to a set of images to generate results. The results may be obtained as a probability map for each image in the set of images. The model may be trained by accessing a set of labeled images, each image associated with a label indicating a location of a feature within a respective image. An initial set of parameters is accessed. An encoder is initialized with the initial set of parameters. The encoder is applied to the set of labeled images to generate a prediction of a feature location within each image. The initial set of parameters are updated based on the predictions and the label associated with the labeled images. The updated set of parameters and an additional set of parameters generated using a set of unlabeled images are aggregated.

Abstract: The invention relates to a battery, in particular to a hybrid battery. The invention provides a hybrid battery that is easy to replace a terminal block and has low maintenance cost, comprising a casing and at least two different sets of battery cells arranged in the casing, wherein the casing is detachably provided with a terminal block, the terminal block is electrically connected with the electrode of the battery cells. When in use, the terminal block in the invention can be detached from the hybrid battery in time if the terminal block is oxidized and blackened for long time use, and only the terminal block is replaced instead of the entire hybrid battery, therefore, the maintenance cost of the hybrid battery is low.

Abstract: The invention discloses a low-viscosity hydroxyl-terminated resin with diisocyanate as a core, and a preparation method therefor and the use thereof. During preparation, 1 mole of a micromolecular polyol is first modified with 1-3 moles of a monoepoxide so as to obtain a modified polyol; and then 2 moles of the modified polyol is reacted with 1-3 moles of a diisocyanate so as to obtain the hydroxyl-terminated resin. The prepared hydroxyl-terminated resin has the advantages of simple synthesis process, high solid content and low viscosity; the hydroxyl value thereof (at 80% solid mass content) is 140-300 mg KOH/g and the viscosity thereof at 25° C. (at 80% solid mass content) is 300-3000 cp.

Abstract: The present invention discloses a combined starting power supply, comprising a lead acid battery, a lithium battery and a lithium battery protection circuit, wherein the lithium battery protection circuit comprises a first input, a second input, a first output and a second output; a negative electrode of the lithium battery is connected to the first input, and a positive electrode of the lithium battery is connected to the second input; and a negative electrode of the lead acid battery is connected to the first output, and a positive electrode of the lead acid battery is connected to the second output. The combined starting power supply of the present invention increases the safety thereof by adopting a lithium battery; and the lithium-ion battery is always put in a safe working state by means of the lithium battery protection circuit during charging and discharging processes.

Abstract: The present disclosure discloses a wind-solar reactor system and a working method thereof. The wind-solar reactor system comprises a nuclear reactor system, a wind power generation system, a solar power storage system and a balance energy system, wherein the nuclear reactor system uses an integrated small modular reactor design, the solar power storage system uses a tower-type solar power storage system design, and a hydrogen production system uses a copper-chlorine cycle hydrogen production technology. A reactor keeps rated full-power operation, generated electricity is adjusted and distributed through a power controller, most of the electricity is used for smoothing the fluctuation of wind power generation, and the excess electricity is used for hydrogen storage of the hydrogen system. Solar power is used for heating saturated steam generated by the reactor into superheated steam through a heater, and then the superheated steam enters a high-pressure cylinder to do work by expansion.

Abstract: The present invention discloses a combined starting power supply, comprising a lead acid battery, a lithium battery and a lithium battery protection circuit, wherein the lithium battery protection circuit comprises a first input, a second input, a first output and a second output; a negative electrode of the lithium battery is connected to the first input, and a positive electrode of the lithium battery is connected to the second input; and a negative electrode of the lead acid battery is connected to the first output, and a positive electrode of the lead acid battery is connected to the second output. The combined starting power supply of the present invention increases the safety thereof by adopting a lithium battery; and the lithium-ion battery is always put in a safe working state by means of the lithium battery protection circuit during charging and discharging processes.

Abstract: The invention relates to a battery, in particular to a hybrid battery. The invention provides a hybrid battery that is easy to replace a terminal block and has low maintenance cost, comprising a casing and at least two different sets of battery cells arranged in the casing, wherein the casing is detachably provided with a terminal block, the terminal block is electrically connected with the electrode of the battery cells. When in use, the terminal block in the invention can be detached from the hybrid battery in time if the terminal block is oxidized and blackened for long time use, and only the terminal block is replaced instead of the entire hybrid battery, therefore, the maintenance cost of the hybrid battery is low.

Abstract: The invention discloses a battery covering structure with replaceable terminals, comprising a covering and terminals, the terminals are located on the covering, and the covering is used for connecting with the battery body, the terminals are detachably connected with the covering. The invention makes the replacement of terminals convenient and quick, which enables the structure to be matched with various types of automobiles and motorcycles, and is beneficial to improving the applicability of battery.

Abstract: The invention discloses a low-viscosity hydroxyl-terminated resin with diisocyanate as a core, and a preparation method therefor and the use thereof. During preparation, 1 mole of a micromolecular polyol is first modified with 1-3 moles of a monoepoxide so as to obtain a modified polyol; and then 2 moles of the modified polyol is reacted with 1-3 moles of a diisocyanate so as to obtain the hydroxyl-terminated resin. The prepared hydroxyl-terminated resin has the advantages of simple synthesis process, high solid content and low viscosity; the hydroxyl value thereof (at 80% solid mass content) is 140-300 mg KOH/g and the viscosity thereof at 25° C. (at 80% solid mass content) is 300-3000 cp.

Abstract: The present invention relates to novel engineered lower eukaryotic host cells for expressing heterologous proteins and to methods of generating such strains.

Abstract: The present invention relates to novel engineered lower eukaryotic host cells for expressing heterologous proteins and to methods of generating such strains.

Abstract: A replaceable and versatile hermetical lead-acid cell comprises a top cover and a casing. The top cover has a cap disposed at its top portion. The top cover and casing are sealed together by resin sealable glue filled therebetween. Plural electrode plates, between which dilute sulfuric acid is filled, are positioned in the casing. In addition, a divider is placed between every two electrode plates. Four electrode terminal posts are further provided at the top portion of the top cover and are adjacent to four corners of the top cover. The invention can replace various kinds of cells in marketplace, meet requirements of difference motorcycle, and improve capacity of the cell.