Patents by Inventor RONGHUA TU

RONGHUA TU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt type and crystal type of 4h-pyrazolo [1, 5-alpha] benzimidazole compound and preparation method and intermediate thereof
    Patent number: 10941150
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof. The 4H-pyrazolo[1,5-alpha]benzimidazole compound has the structure of Compound 2.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: March 9, 2021
    Assignees: HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC., HUMANWELL HEALTHCARE (GROUP) CO., LTD.
    Inventors: Xuehai Wang, Charles Z. Ding, Jie Shen, Shuhui Chen, Lie Li, Gang Li, Yong Xu, Cailin Wang, Ronghua Tu, Jimeng Wang, Yang YuE, Biao Deng, Hailiang Chen, Hui Liu, Wenjie Sun, Cong Wang, Lu Huang, Zheng Wang, Weidong Li
  • BTK inhibitor
    Patent number: 10662174
    Abstract: Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: May 26, 2020
    Assignee: HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC.
    Inventors: Xuehai Wang, Chengde Wu, Yong Xu, Chunli Shen, Li'e Li, Guoping Hu, Yang Yue, Jian Li, Diliang Guo, Nengyang Shi, Lu Huang, Shuhui Chen, Ronghua Tu, Zhongwen Yang, Xuwen Zhang, Qiang Xiao, Hua Tian, Yanping Yu, Hailiang Chen, Wenjie Sun, Zhenyu He, Jie Shen, Jing Yang, Jing Tang, Wen Zhou, Jing Yu, Yi Zhang, Quan Liu
  • Salt Type And Crystal Type Of 4h-Pyrazolo [1, 5-Alpha] Benzimidazole Compound And Preparation Method And Intermediate Thereof
    Publication number: 20190375756
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 12, 2019
    Inventors: Xuehai WANG, Charles Z. DING, Jie SHEN, Shuhui CHEN, Lie LI, Gang LI, Yong XU, Cailin WANG, Ronghua TU, Jimeng WANG, Yang YUE, Biao DENG, Hailiang CHEN, Hui LIU, Wenjie SUN, Cong WANG, Lu HUANG, Zheng WANG, Weidong LI
  • Salt type and crystal type of 4H-pyrazolo [1, 5-alpha] benzimidazole compound and preparation method and intermediate thereof
    Patent number: 10428073
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1,5-alpha]benzimidazole compound and a preparation method and intermediate thereof.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: October 1, 2019
    Assignees: Hubei Bio-Pharmaceutical Industrial Technological Institute Inc., Humanwell Healthcare (Group) Co., Ltd.
    Inventors: Xuehai Wang, Charles Z. Ding, Jie Shen, Shuhui Chen, Lie Li, Gang Li, Yong Xu, Cailin Wang, Ronghua Tu, Jimeng Wang, Yang Yue, Biao Deng, Hailiang Chen, Hui Liu, Wenjie Sun, Cong Wang, Lu Huang, Zheng Wang, Weidong Li
  • SALT TYPE AND CRYSTAL TYPE OF 4H-PYRAZOLO [1, 5-ALPHA] BENZIMIDAZOLE COMPOUND AND PREPARATION METHOD AND INTERMEDIATE THEREOF
    Publication number: 20180258093
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.
    Type: Application
    Filed: September 29, 2016
    Publication date: September 13, 2018
    Inventors: Xuehai WANG, Charles Z. DING, Jie SHEN, Shuhui CHEN, Lie LI, Gang LI, Yong XU, Cailin WANG, Ronghua TU, Jimeng WANG, Yang YUE, Biao DENG, Hailiang CHEN, Hui LIU, Wenjie SUN, Cong WANG, Lu HUANG, Zheng WANG, Weidong LI
  • Analogues of 4H-pyrazolo[1,5-a] benzimidazole compound as PARP inhibitors
    Patent number: 9856262
    Abstract: Disclosed is a series of analogs of 4H-pyrazolo[1,5-?]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 2, 2018
    Assignees: Hubei Bio-Pharmaceutical Industrial Technological Institute Inc., Humanwell Healthcare (Group) Co., Ltd., Medshine Discovery Inc.
    Inventors: Xuehai Wang, Zhaozhong Ding, Yong Xu, Shuhui Chen, Lie Li, Gang Li, Ronghua Tu, Cailin Wang, Yang Yue, Zhibo Zhang, Hailiang Chen, Wenjie Sun, Lu Huang
  • BTK INHIBITOR
    Publication number: 20170313683
    Abstract: Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
    Type: Application
    Filed: July 14, 2017
    Publication date: November 2, 2017
    Inventors: Xuehai Wang, Chengde Wu, Yong Xu, Chunli Shen, Li'e Li, Guoping Hu, Yang Yue, Jian Li, Diliang Guo, Nengyang Shi, Lu Huang, Shuhui Chen, Ronghua Tu, Zhongwen Yang, Xuwen Zhang, Qiang Xiao, Hua Tian, Yanping Yu, Hailiang Chen, Wenjie Sun, Zhenyu He, Jie Shen, Jing Yang, Jing Tang, Wen Zhou, Jing Yu, Yi Zhang, Quan Liu
  • Capsule containing total flavonoids of desmodium styracifolium, method for preparing the same and use
    Patent number: 9724374
    Abstract: A capsule containing total flavonoids of Desmodium styracifolium, a method for preparing the same and a use of the capsule containing total flavonoids of Desmodium styracifolium are provided. Specifically, the capsule includes total flavonoids of Desmodium Styracifolium provided in a form of alcohol extract of Desmodium Styracifolium and a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: August 8, 2017
    Assignees: HUMANWELL HEALTHCARE (GROUP) CO., LTD., WUHAN OPTICS VALLEY HUMANWELL BIO-PHARMACEUTICAL CO., LTD., HUBEI BIOLOGICAL MEDICINE INDUSTRIAL TECHNOLOGY INSTITUTE CO., LTD., WUHAN CHEMLIGAND BIO-PHARMACEUTICAL CO., LTD.
    Inventors: Xuehai Wang, Yong Xu, Li'e Li, Jie Li, Ronghua Tu, Gang Chen, Rubin Cao, Yun Feng, Zhongwen Yang, Zhaoze Fan, Yanping Yu, Qiang Xiao, Lu Huang, Chengbing Yang, Tianci Huang, Hua Tian, Jing Yang
  • SOLID DISPERSION CONTAINING DESMODIUM STYRACIFOLIUM (OSB.) MERR. FLAVONOIDS, METHOD OF PREPARING SAME, AND USE THEREOF
    Publication number: 20170028007
    Abstract: A solid dispersion containing Desmodium Styracifolium (Osb.) Merr. flavonoids, method of preparing same and use thereof. The Desmodium Styracifolium (Osb.) Merr. flavonoids are alcohol extract of Desmodium Styracifolium (Osb.) Merr., and the solid dispersion is used for preparing a drug for treating urinary tract calculi.
    Type: Application
    Filed: July 15, 2014
    Publication date: February 2, 2017
    Inventors: XUEHAI WANG, LI'E LI, YONG XU, JIE LI, RONGHUA TU, GANG CHEN, RUBIN CAO, YUN FENG, ZHONGWEN YANG, ZHAOZE FAN, YANPING YU, QIANG XIAO, LU HUANG, CHENGBING YANG, TIANCI HUANG, HUA TIAN, JING YANG
  • ANALOGUES OF 4H-PYRAZOLO[1,5-a] BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS
    Publication number: 20170029430
    Abstract: Disclosed is a series of analogues of 4H-pyrazolo[1,5-?]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.
    Type: Application
    Filed: March 30, 2015
    Publication date: February 2, 2017
    Inventors: Xuehai WANG, Zhaozhong DING, Yong XU, Shuhui CHEN, Lie LI, Gang LI, Ronghua TU, Cailin WANG, Yang YUE, Zhibo ZHANG, Hailiang CHEN, Wenjie SUN, Lu HUANG
  • PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARING THE SAME AND USE THEREOF
    Publication number: 20160303178
    Abstract: Disclosed are a pharmaceutical composition, a method for preparing the same and use thereof. The pharmaceutical composition consists of total flavonoids of Desmodium Styracifolium as an active ingredient and a pharmaceutically acceptable excipient. The pharmaceutical composition can be formulated in a form of a medicament formulation suitable to administration in clinic, and can be used in preparation of clinic treatment medicaments for treating dampness-heat and urinary stone (stagnation of dampness-heat).
    Type: Application
    Filed: July 15, 2014
    Publication date: October 20, 2016
    Inventors: XUEHAI WANG, JIE LI, LI'E LI, YONG XU, RONGHUA TU, GANG CHEN, RUBIN CAO, YUN FENG, ZHONGWEN YANG, ZHAOZE FAN, YANPING YU, QIANG XIAO, LU HUANG, CHENGBING YANG, TIANCI HUANG, HUA TIAN, JING YANG
  • CAPSULE CONTAINING TOTAL FLAVONOIDS OF DESMODIUM STYRACIFOLIUM, METHOD FOR PREPARING THE SAME AND USE
    Publication number: 20160296579
    Abstract: A capsule containing total flavonoids of Desmodium styracifolium, a method for preparing the same and a use of the capsule containing total flavonoids of Desmodium styracifolium are provided. Specifically, the capsule includes total flavonoids of Desmodium Styracifolium provided in a form of alcohol extract of Desmodium Styracifolium and a pharmaceutically acceptable excipient.
    Type: Application
    Filed: July 15, 2014
    Publication date: October 13, 2016
    Inventors: XUEHAI WANG, YONG XU, LI'E LI, JIE LI, RONGHUA TU, GANG CHEN, RUBIN CAO, YUN FENG, ZHONGWEN YANG, ZHAOZE FAN, YANPING YU, QIANG XIAO, LU HUANG, CHENGBING YANG, TIANCI HUANG, HUA TIAN, JING YANG