Patents by Inventor Rongliang Lou

Rongliang Lou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic compounds and methods of making and using the same
    Patent number: 8202843
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: June 19, 2012
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Jay J. Farmer, Ashoke Bhattacharjee, Yi Chen, Joel A. Goldberg, Joseph A. Ippolito, Zoltan F. Kanyo, Rongliang Lou, Adegboyega K. Oyelere, Edward C. Sherer, Joyce A. Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same
    Publication number: 20120010200
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 12, 2012
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Process for the synthesis of triazoles
    Publication number: 20100234615
    Abstract: The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
    Type: Application
    Filed: June 8, 2006
    Publication date: September 16, 2010
    Inventors: Shili Chen, Rongliang Lou, Yusheng Wu, Jiacheng Zhou, Roger Hanselmann
  • BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20100234591
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: April 26, 2010
    Publication date: September 16, 2010
    Applicant: Rib-X Pharmaceuticals, Inc.
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7705026
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 27, 2010
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • PROCESS FOR THE SYNTHESIS OF BIARYL OXAZOLIDNONES
    Publication number: 20100022772
    Abstract: The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
    Type: Application
    Filed: July 28, 2004
    Publication date: January 28, 2010
    Applicant: RIB-X PHARMACEUTICALS, INC.
    Inventors: Yusheng Wu, Chen Shili, Yi Chen, Roger Hanselmann, Rongliang Lou, Jiacheng Zhou
  • BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20090118502
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: November 21, 2008
    Publication date: May 7, 2009
    Applicant: Rib-X Pharmaceuticals, Inc.
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Josseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7456206
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: November 25, 2008
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Bifunctional heterocyclic compounds and methods of making and using same
    Publication number: 20080119419
    Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 22, 2008
    Inventors: Deping Wang, Joyce Sutcliffe, Adegboyega Oyelere, Timothy McConnell, Joseph Ippolito, John Abelson, Dane Springer, Joseph Salvino, Joel Goldberg, Rongliang Lou, Jay Farmer, Erin Duffy, Ashoke Bhattacharjee
  • Bifunctional heterocyclic compounds and methods of making and using same
    Patent number: 7335753
    Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: February 26, 2008
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Deping Wang, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Timothy S. McConnell, Joseph A. Ippolito, John N. Abelson, Dane M. Springer, Joseph M. Salvino, Rongliang Lou, Joel A. Goldberg, Jay J. Farmer, Erin M. Duffy, Ashoke Bhattacharjee
  • Macrocyclic Compounds And Methods Of Making And Using The Same
    Publication number: 20080045585
    Abstract: The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
    Type: Application
    Filed: February 25, 2005
    Publication date: February 21, 2008
    Inventors: Jay Farmer, Ashoke Bhattacharjee, Yi Chen, Joel Goldberg, Joseph Ippolito, Zoltan Kanyo, Rongliang Lou, Adegboyega Oyelere, Edward Sherer, Joyce Sutcliffe, Deping Wang, Yusheng Wu, Yanming Du
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7148219
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: December 12, 2006
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Rongliang Lou, Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Biaryl heterocyclic compounds and methods of making and using the same
    Publication number: 20060264426
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: July 14, 2006
    Publication date: November 23, 2006
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay Farmer, Joel Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega Oyelere, Joseph Salvino, Dane Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Bifunctional heterocyclic compounds and methods of making and using same
    Publication number: 20060264385
    Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
    Type: Application
    Filed: February 21, 2006
    Publication date: November 23, 2006
    Inventors: Deping Wang, Joyce Sutcliffe, Adegboyega Oyelere, Timothy McConnell, Joseph Ippolito, John Abelson, Dane Springer, Joseph Salvino, Rongliang Lou, Joel Goldberg, Jay Farmer, Erin Duffy, Ashoke Bhattacharjee
  • Halogenated biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7129259
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiety, and at least one heterocyclic moiety, that are useful as such agents.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: October 31, 2006
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Shili Chen, Jiacheng Zhou, Yusheng Wu, Deping Wang, Joseph M. Salvino, Adegboyega K. Oyelere, Rongliang Lou
  • Bifunctional heterocyclic compounds and methods of making and using same
    Patent number: 7091196
    Abstract: The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents, and/or prokinetic (gastrointestinal modulatory) agents, having the formula: or pharmaceutically acceptable salts, esters, or prodrugs thereof.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: August 15, 2006
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Deping Wang, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Timothy S. McConnell, Joseph A. Ippolito, John N. Abelson, Dane M. Springer, Joseph M. Salvino, Rongliang Lou, Joel A. Goldberg, Jay J. Farmer, Erin M. Duffy, Ashoke Bhattacharjee
  • Halogenated biaryl heterocyclic compounds and methods of making and using the same
    Publication number: 20060148869
    Abstract: The present invention relates generally to the field of anti-infective anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiety, and at least one heterocyclic moiety, that are useful as such agents.
    Type: Application
    Filed: February 23, 2006
    Publication date: July 6, 2006
    Inventors: Shili Chen, Jiacheng Zhou, Yusheng Wu, Deping Wang, Joseph Salvino, Adegboyega Oyelere, Rongliang Lou, Ashoke Bhattacharjee, Yi Chen
  • N-hydroxysuccinimide process for conversion of phenols to carboxamides
    Patent number: 7057035
    Abstract: A process for converting an aryl triflate, heteroaryl triflate, aryl halide or heteroaryl halide to an N-hydroxysuccinimido ester is disclosed. The process involves reacting the triflate or halide with carbon monoxide and N-hydroxysuccinimide in a solvent in the presence of a palladium catalyst and a base.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: June 6, 2006
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Mark P. Wentland, Rongliang Lou
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 6969726
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: November 29, 2005
    Inventors: Rongliang Lou, Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • N-hydroxysuccinimide process for conversion of phenols to carboxamides
    Publication number: 20050215799
    Abstract: A process for converting an aryl triflate, heteroaryl triflate, aryl halide or heteroaryl halide to an N-hydroxysuccinimido ester is disclosed. The process involves reacting the triflate or halide with carbon monoxide and N-hydroxysuccinimide in a solvent in the presence of a palladium catalyst and a base.
    Type: Application
    Filed: January 14, 2005
    Publication date: September 29, 2005
    Inventors: Mark Wentland, Rongliang Lou